Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease

Tang, Peng; Li, Chong; Li, Xiaoqing; Liu, Yue; Liu, Peng; Hou, Chen; Li, Rui

doi:10.1155/2014/208408

Cited by 57 publications

(35 citation statements)

References 21 publications

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“…12 Interestingly, the combination of TNF-a with the ratio of P-Tau/a-synuclein was that which best classified PD patients. Conversely, there were no differences in plasma IL-6 levels in PD patients and controls, in contrast to earlier studies that reported increases 13,14,[35][36][37] or decreases 38 in this parameter. However, the levels of IL-6 in PD patients apparently augment as the disease becomes more severe, both in terms of motor and nonmotor features, as shown by the positive correlations with the UPDRS scores I to III.…”

Section: E L G a D O -A L V A R A D O E T A Lcontrasting

confidence: 99%

Tau/α‐synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study

et al. 2017

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Section: E L G a D O -A L V A R A D O E T A Lcontrasting

confidence: 99%

Tau/α‐synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study

et al. 2017

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“…Studies reporting increased serum RANTES levels in association with IL-15, IL-8, and MCP-1 in PD patients suggest that the dysregulation in the peripheral cytokine network might be related to the pathogenesis and underlying neurodegeneration [19, 27, 28]. In addition, RANTES serum levels were reported to correlate with disease severity [29, 30]. …”

Section: Discussionmentioning

confidence: 99%

A Case-Control Association Study ofRANTES (-28C>G)Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey

Sahin-Calapoglu

Demirci

Calapoğlu

et al. 2016

Parkinson's Disease

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Background. Recent studies have revealed that inflammatory processes are involved in the pathogenesis of Parkinson's disease (PD). Multiple lines of evidence have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. We have examined whether genetic polymorphisms at the genes encoding chemokines IL-8 (-251A>T), MCP-1 (-2518A/G), and RANTES (-28C>G) and chemokine receptors CCR2 (V64I) and CCR5 (-Δ32) were associated with sporadic PD risk in Isparta, Turkey. Method. The pilot case-control association study included 30 PD patients and 60 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms. Their genotype and haplotype frequencies were compared statistically. Results. One SNP (-28C>G) in RANTES revealed a significant association with PD (P (allele) < 0.0001, p-trend = 0.0007). The risk allele (G) in the homozygous and dominant models (OR = 17.29 and 32.10, 95% CI = 0.86–347.24 and 1.74–591.937, resp.) suggests additional PD risk. The haplotype TGCAN from the IL-8 (-251A>T), MCP-1 (-2518A>G), RANTES (-28C>G), CCR-2 (V64I), and CCR-5 (-Δ32) has protective effect (OR = 0.08 [CI = 0.01–0.63], p = 0.019). Conclusions. Our data are the first indication of the role of RANTES (-28C>G) in PD risk.

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“…The measured cytokines were selected based on the reported alterations in the C9orf72 knock-out murine model studies [1][2][3]. Additionally, RANTES and IL-8 were chosen based on assay availability and based on previous studies showing alterations in the peripheral levels of these cytokines especially in ALS and Parkinson's disease [22][23][24][25].…”

Section: Cytokine and Chemokine Analyses In Patients With Ftldmentioning

confidence: 99%

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

et al. 2019

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In this study, our aim was to evaluate potential peripheral inflammatory changes in frontotemporal lobar degeneration (FTLD) patients carrying or not the C9orf72 repeat expansion. To this end, levels of several inflammatory markers (MCP-1, RANTES, IL-10, IL-17A, IL-12p, IFN-γ, IL-1β, IL-8, and hs-CRP) and blood cells counts in plasma and/or serum of FTLD patients (N = 98) with or without the C9orf72 repeat expansion were analyzed. In addition, we evaluated whether the analyzed peripheral inflammatory markers correlated with disease progression or distinct clinical phenotypes under the heterogenous FTLD spectrum. Elevated levels of pro-inflammatory RANTES or MCP-1 and decreased levels of anti-inflammatory IL-10 were found to associate with Parkinsonism and a more rapid disease progression, indicated by longitudinal measurements of either MMSE or ADCS-ADL decline. These findings were observed in the total cohort in general, whereas the C9orf72 repeat expansion carriers showed only slight differences in IL-10 and hemoglobin levels compared to non-carriers. Furthermore, these C9orf72 repeat expansion-associated differences were observed mostly in male subjects. The females in general showed elevated levels of several pro-inflammatory markers compared to males regardless of the C9orf72 genotype. Our study suggests that pro-inflammatory changes observed in the early symptomatic phase of FTLD are associated with distinct clinical profiles and a more rapid disease progression, and that the C9orf72 repeat expansion and gender may also affect the inflammatory profile in FTLD.

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Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease

Cited by 57 publications

References 21 publications

Tau/α‐synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study

Tau/α‐synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study

A Case-Control Association Study ofRANTES (-28C>G)Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

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