Correlation Between Salivary α-Amylase Activity and Pain Scale in Patients With Chronic Pain

Abstract

Because there was a significant correlation between VAS pain scale and salivary alpha-amylase, we suggest that this biomarker may be a good index for the objective assessment of pain intensity. In addition, a simple to use portable analyzer may be useful for such assessment.

Correlation Between Wong-Baker Faces Pain Scale and Salivary Alpha-Amylase Level in Children Aged 6–11 Years

“…These results are similar to those reported previously by Shirasaki and Motamayel [4,5]. It has been reported that psychological stress activates the SAM system [6].…”

“…Shirasaki found good correlation between scales of pain intensity and SAA. This is because painful stimuli activate the sympathetic-adrenal medullary (SAM) system and hypothalamic-pituitary-adrenal (HPA) axis [4]. Some children need their primary teeth to be extracted under local anesthetic injection during the exfoliation period.…”

Salivary amylase activity is useful for assessing perioperative stress in response to pain in patients undergoing endoscopic submucosal dissection of gastric tumors under deep sedation

“…Furthermore, the observation that pentazocine, but not midazolam, effectively reduced the high sAMY level as well as the body motion indicates that the stress shown by sAMY in a patient under DS is physiological stress; namely, excitation of the sympathetic nervous system caused by pain stimuli, rather than psychological stress. The sAMY has previously been reported to be useful for assessing pain in patients suffering from chronic low back or leg pain [20]. However, that report showed the sAMY to be related to the self-assessment of pain in a patient who was aware.…”

The Clinical Efficacy of Reflexology in Nursing Home Residents with Dementia

“…46 Recent evidence suggests that sAA may represent an objective neuroendocrine measure for changes in affect and pain intensity. [39][40][41][42] Because reflexology seems to be of clinical usefulness for reducing distress, further clinical and laboratory studies into the mechanisms by which reflexology acts upon the sympathetic nervous system are warranted.…”

“…[38][39] sAA possesses diurnal qualities, that is, levels shift through the course of the day. [40][41][42] Thus, saliva samples (of 0.5-1.0 mL volume each) were collected in subjects within 30 minutes of awakening and every 3 hours thereafter (midmorning, early afternoon and late afternoon) to capture the circadian pattern. On each day, the collection procedures was identical.…”