Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas

Bitencourt, Almir Galvão Vieira; Lima, Eduardo Nóbrega Pereira; Chojniak, Rubens; Marques, Elvira Ferreira; Souza, Juliana Alves de; Graziano, Luciana; Andrade, Wesley Pereira; Osorio, C

doi:10.1590/s0100-39842014000200006

Cited by 31 publications

(18 citation statements)

References 25 publications

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“…In agreement with the foregoing, numerous studies in primary breast cancers have demonstrated statistically significant associations between higher values of maximum SUV and histological type (IDC), histological grade (III), tumor diameter, mitotic index, Ki-67 expression, nuclear atypia, hormone receptor (HR) negativity, high score of HER2 expression, lymph node metastasis all related to breast carcinomas' higher aggressiveness and more unfavorable prognosis ( Fig. 1) (Bitencourt et al, 2014;Lavayssière et al, 2009;Kitajima et al, 2015;Ueda et al, 2008). On the contrary, Shimoda et al showed a significant association between SUV values and mitotic counts, Ki-67, and nuclear grade, but not with tumor size, age, histology, HR expression and HER2 overexpression (Shimoda et al, 2007).…”

Section: Correlation Between 18 F-fdg Pet/ct Results and Breast Cancesupporting

confidence: 80%

Positron emission tomography in breast cancer: 18F- FDG and other radiopharmaceuticals

Iakovou

Giannoula

Gkantaifi

et al. 2018

European J Hybrid Imaging

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Background: Breast cancer heterogeneity reflects the complex biology of this disease. Breast cancer subtypes, as identified either by immunohistochemistry (IHC) or by gene expression analysis, present different molecular characteristics and prognosis. In this context, molecular imaging techniques providing functional information, contribute in evaluating response to treatment and long-term prognosis among different subtypes. Nuclear imaging diagnosis modalities play an important role for conducting research on cancer biology and developing new treatment approaches. Positron Emission Tomography (PET) is a radionuclide based imaging method that has the potential to locate the tumor, define its staging, and monitor its response to treatment.Results: In the current study, we will review the utility of the most widely used molecular imaging technique, 18 F-fluorodeoxyglucose ( 18 F-FDG) PET, in order to determine the relationship between standardized uptake values (SUVs) and immunohistopathological factors, as well as to clarify whether PET is able to predict breast cancer phenotypes. Moreover, we will discuss the rising development of new radiopharmaceuticals in PET imaging, such as 18 F-fluoro-17-estradiol (FES), 18 F-fluoro-l-thymidine (FLT), 18 F-fluoromisonidazole (FISO), and 89 Zr-immuno-PET, which give more information about tumor characteristics. Conclusions: In order to improve clinical decision making, enabling hereafter more successful individualized therapies, it is imperative to combine PET radiopharmaceuticals and imaging techniques of critical biologic and pathologic phenomena, including ER, PR and HER2 expression, angiogenesis, hypoxia, apoptosis and metabolic changes in the microenviroment of breast tumors. BackgroundBreast cancer is the most frequently diagnosed noncutaneous malignancy in women worldwide, accounting for approximately 30% of all new cancer diagnoses and about 14% of all cancer deaths in women. About 63,410 new cases of female breast carcinoma in situ and 252,710 new cases of invasive breast cancer will be diagnosed in 2017 among United States (US) women. It is estimated that one in eight women will develop breast cancer during their life, while it is the second most common cause of cancer

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Section: Correlation Between 18 F-fdg Pet/ct Results and Breast Cancesupporting

confidence: 80%

Positron emission tomography in breast cancer: 18F- FDG and other radiopharmaceuticals

Iakovou

Giannoula

Gkantaifi

et al. 2018

European J Hybrid Imaging

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“… 8 , 27 , 28 In addition, 18 F-FDG uptake is lower on tumors with positive hormone receptor expression (luminal A and luminal B subtypes), when compared with less-differentiated tumors with negative hormone receptor expression (Her-2 and triple-negative subtypes). 29 , 30 Several methods have been developed to improve the current results of PET-CT for the diagnosis of breast lesions. Recently, a research group has been developing a dedicated simultaneous PET-MRI breast imaging system, which allows a combination of a high-resolution PET scan with morphologic and functional MRI data in a single study.…”

Section: Discussionmentioning

confidence: 99%

Multiparametric Evaluation of Breast Lesions Using PET-MRI

Bitencourt

Lima

Chojniak³

et al. 2014

Medicine

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The purpose of this study was to evaluate the diagnostic accuracy of multiparametric evaluation of breast lesions combining information of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted imaging (DWI), and 18F-fluoro-deoxi-glucose (18F-FDG) positron emission tomography/computed tomography (PET-CT). After approval of the institutional research ethics committee, 31 patients with suspicious breast lesions on MRI performed 18F-FDG PET-CT with a specific protocol for breast evaluation. Patients’ mean age was 47.8 years (range, 29–77 years). Positron emission tomography and magnetic resonance imaging (PET-MRI) images were fused. A lesion was considered positive on multiparametric evaluation if at least 1 of the following was present: washout/type 3 kinetic curve on DCE-MRI, restricted diffusion on DWI with minimum apparent diffusion coefficient value <1.00 × 10−3 mm2/s, and abnormal metabolism on 18F-FDG PET-CT (higher than the physiologic uptake of the normal breast parenchyma). Thirty-eight lesions with histologic correlation were evaluated on the 31 included patients, being 32 mass lesions (84.2%), and 6 nonmass lesions (15.8%). Lesions’ mean diameter was 31.1 mm (range, 8–94 mm). Multiparametric evaluation provided 100% sensitivity, 55.5% specificity, 87.9% positive predictive value, 100% negative predictive value, and 89.5% accuracy, with 29 true-positives results, 5 true-negatives, 4 false-positives, and no false-negative results. Multiparametric evaluation with PET-MRI functional data showed good diagnostic accuracy to differentiate benign from malignant breast lesions, reducing the number of unnecessary biopsies, without missing any diagnosis of cancer in our case series.

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“…Recently, several studies were developed about imaging quality ( 10 , 11 ) , recommendations for breast cancer screening ( 12 ) , adherence to mammography ( 13 ) , new techniques related to breast cancer diagnosis ( 14 - 16 ) , as well as about the relevance of internal audits in mammography services as a tool to depict the service quality ( 17 ) .…”

Section: Introductionmentioning

confidence: 99%

Evolution of mammographic image quality in the state of Rio de Janeiro

et al. 2015

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ObjectiveTo evaluate the evolution of mammographic image quality in the state of Rio de Janeiro on the basis of parameters measured and analyzed during health surveillance inspections in the period from 2006 to 2011.Materials and MethodsDescriptive study analyzing parameters connected with imaging quality of 52 mammography apparatuses inspected at least twice with a one-year interval.ResultsAmongst the 16 analyzed parameters, 7 presented more than 70% of conformity, namely: compression paddle pressure intensity (85.1%), films development (72.7%), film response (72.7%), low contrast fine detail (92.2%), tumor mass visualization (76.5%), absence of image artifacts (94.1%), mammography-specific developers availability (88.2%). On the other hand, relevant parameters were below 50% conformity, namely: monthly image quality control testing (28.8%) and high contrast details with respect to microcalcifications visualization (47.1%).ConclusionThe analysis revealed critical situations in terms of compliance with the health surveillance standards. Priority should be given to those mammography apparatuses that remained non-compliant at the second inspection performed within the one-year interval.

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Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas

Cited by 31 publications

References 25 publications

Positron emission tomography in breast cancer: 18F- FDG and other radiopharmaceuticals

Positron emission tomography in breast cancer: 18F- FDG and other radiopharmaceuticals

Multiparametric Evaluation of Breast Lesions Using PET-MRI

Evolution of mammographic image quality in the state of Rio de Janeiro

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