Correlation Between Incisional Biopsy Histological Subtype and a Mohs Surgery Specimen for Nonmelanoma Skin Cancer

Cortés-Peralta, Ely Cristina; Ocampo‐Candiani, Jorge; Vázquez‐Martínez, Osvaldo; Gutiérrez-Villarreal, Ilse Marilú; Miranda-Maldonado, Ivette; Garza‐Rodríguez, Verónica

doi:10.1016/j.ad.2017.08.003

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…Eleven papers comparing histopathological results between biopsies and complete excision of keratinocyte carcinoma (BCC, SCC or both), via conventional surgery [1][2][3][4][5][6][7] or MMS, [8][9][10][11] were analysed. A supplementary study evaluating the incidence of BCC with mixed histopathological subtypes in MMS surgical sections was included.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Several series have compared histopathological findings between the biopsy and the final excision, either via conventional surgery 1‐7 or Mohs micrographic surgery (MMS) 8‐11 . However, the objectives and methodology vary between studies and results are difficult to compare.…”

Section: Introductionmentioning

confidence: 99%

“…2 Several series have compared histopathological findings between the biopsy and the final excision, either via conventional surgery [1][2][3][4][5][6][7] or Mohs micrographic surgery (MMS). [8][9][10][11] However, the objectives and methodology vary between studies and results are difficult to compare. Most focus on BCC or include only a small number of squamous cell carcinoma (SCC) and are based in an American [6][7][8][9][10] or European [2][3][4][5]11 population.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] However, the objectives and methodology vary between studies and results are difficult to compare. Most focus on BCC or include only a small number of squamous cell carcinoma (SCC) and are based in an American [6][7][8][9][10] or European [2][3][4][5]11 population.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological discrepancy between biopsy and Mohs micrographic surgery in keratinocyte carcinoma: A 464 case series in an Australian population

Stewart¹,

Bandera

Lee³

2020

Aust J Dermatology

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Background/objectives Therapeutic approaches to keratinocyte carcinoma rely on the accuracy of the biopsy to correctly identify, grade or subtype the tumour. Several studies have investigated the frequency and nature of histopathological discordance between the biopsy and final excision specimen. We analysed information extracted from an Australian Mohs micrographic surgery (MMS) database and compared similar studies. Methods An Australian MMS database was retrospectively reviewed for a period of one year. Correlation was made between the preoperative lesion diagnosis based on the formal pathology report and the histopathological results reported at the time of MMS. A systematic PubMed review of similar articles was also performed. Results A total of 464 cancers (406 BCC and 58 SCC) in 399 patients were included. The overall discrepancy rate in the histopathological classification of keratinocyte carcinoma in our study (42.2%) and the proportion of cases in which the biopsy underestimated the aggressiveness of the tumour (12.9%) were consistent with those found in similar studies. The percentage of biopsies that failed to identify an aggressive BCC subtype (31.6%), and that of biopsy‐proven superficial BCC that demonstrated an invasive component in MMS (79.3%), were higher in our study than in comparable studies. The high prevalence of mixed histopathological subtypes, especially amongst BCC with discordant histopathological results, appeared as an important contributing factor. Conclusions Despite subtle differences, the results from this Australian study support the results from similar studies and highlight that the biopsy report should be carefully interpreted in combination with the clinical findings.

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Section: Literature Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Histopathological discrepancy between biopsy and Mohs micrographic surgery in keratinocyte carcinoma: A 464 case series in an Australian population

Stewart¹,

Bandera

Lee³

2020

Aust J Dermatology

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show abstract

“…One study found that 21.1% of biopsies under diagnosed the aggressiveness of BCCs and SCCs when compared with subsequent MMS pathology samples, owing to the heterogeneity of many tumors and lack of complete tumor visualization with biopsy (Izikson et al., 2010). Therefore, if the overall pathology or base of the tumor differs from the pathology of the biopsy sample, this may affect risk stratification and reduce treatment success (Bartoš and Kullová, 2016, Cortés-Peralta et al., 2018, Sexton et al., 1990).…”

Section: Superficial Ablative Proceduresmentioning

confidence: 99%

Management of keratinocyte carcinoma - Special considerations in the elderly

Bailey

Vasicek

Tao

et al. 2019

International Journal of Women's Dermatology

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Keratinocyte carcinomas (KCs) are now an epidemic in The United States of America, especially in elderly patients. KCs, including basal cell carcinoma and squamous cell carcinoma, can lead to disfigurement and occasionally death. However, the lower mortality rate associated with KC compared with melanoma allows for increased flexibility in the selection of treatment. Flexibility in treatment is particularly important in the elderly given that this patient population often has medical comorbidities that should be considered. These patients may have multiple KCs, higher risk tolerance to recurrence, and different concerns about cosmetic outcomes compared with their younger counterparts. We review treatment options for KCs and how the selection of each option may affect the elderly patient.

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Surgical margins required for basal cell carcinomas treated with Mohs micrographic surgery according to tumor features

Cerci

Kubo

Werner

et al. 2020

Journal of the American Academy of Dermatology

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1. Trump DJ. Proclamation on declaring a national emergency concerning the novel coronavirus disease (COVID-19) outbreak. Available at: https://www.whitehouse.gov/presidential-actions/ proclamation-declaring-national-emergency-concerning-novelcoronavirus-disease-covid-19-outbreak/. 2020. Accessed October 12, 2020. 2. CARES Act, S.3548, 116th Congress. Available at: https://www. congress.gov/bill/116th-congress/senate-bill/3548/text. 2020. Accessed October 11, 2020. 3. Gisondi P, Piaserico S, Conti A. Dermatologists and SARS-CoV-2: the impact of the pandemic on daily practice.

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Correlation Between Incisional Biopsy Histological Subtype and a Mohs Surgery Specimen for Nonmelanoma Skin Cancer

Cited by 8 publications

References 6 publications

Histopathological discrepancy between biopsy and Mohs micrographic surgery in keratinocyte carcinoma: A 464 case series in an Australian population

Histopathological discrepancy between biopsy and Mohs micrographic surgery in keratinocyte carcinoma: A 464 case series in an Australian population

Management of keratinocyte carcinoma - Special considerations in the elderly

Surgical margins required for basal cell carcinomas treated with Mohs micrographic surgery according to tumor features

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