2014
DOI: 10.1371/journal.pone.0106256
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Abstract: Paracoccidioidomycosis is the most important systemic mycosis in Latin America. The main entrance of the fungus is the airway. It primarily occurs in the lung, but in its disseminated form may affect any organ. The liver is one of the organs afflicted by this disease and its homeostasis may be impaired. The aim of the present study was to evaluate the evolution of paracoccidioidomycosis in the liver of Swiss mice and correlate morphological factors with the expression of gp43 and with physicochemical analysis … Show more

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Cited by 6 publications
(11 citation statements)
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References 54 publications
(64 reference statements)
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“…In the liver, the number of CFU and granulomas in mice with PCM decreased over the time of infection, although the histopathological changes were still observed until the eighth week. In that study, FT-Raman analysis revealed an increase in the collagen area at the fourth week of infection (10). These results support studies that demonstrate the interaction between Pb and the extracellular matrix in processes of the fungal invasion of tissues, and also demonstrate that in this experimental model, the fourth week may be the period of infection in which an effective response to the disease will or will not occur.…”
Section: Discussionsupporting
confidence: 87%
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“…In the liver, the number of CFU and granulomas in mice with PCM decreased over the time of infection, although the histopathological changes were still observed until the eighth week. In that study, FT-Raman analysis revealed an increase in the collagen area at the fourth week of infection (10). These results support studies that demonstrate the interaction between Pb and the extracellular matrix in processes of the fungal invasion of tissues, and also demonstrate that in this experimental model, the fourth week may be the period of infection in which an effective response to the disease will or will not occur.…”
Section: Discussionsupporting
confidence: 87%
“…In the present study, immunostaining occurred in all the infection periods, although the highest intensity was during the second week, with diffuse distribution in the parenchyma and splenic stroma, in intracellular and extracellular locations, mainly in the areas of red pulp. The gp43 immunostaining pattern in the liver was similar (10).…”
Section: Discussionmentioning
confidence: 77%
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