Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis

Takahashi, Hideaki; Shigefuku, Ryuta; Yoshida, Yoshihito; Ikeda, Hiroki; Matsunaga, Kotaro; Matsumoto, Nobuyuki; Okuse, Chiaki; Sase, Sadanori; Itoh, Fumio; Suzuki, Michihiro

doi:10.3748/wjg.v20.i45.17065

Cited by 25 publications

(24 citation statements)

References 31 publications

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“…Before initiation of ECMO, ultrasonography confirmed adequate filling in the right hepatic artery and the portal vein. The right hepatic arterial blood flow (HAF) and the portal venous blood flow (PVF) had no significant difference from the normal reference level (Table ). After initiation of ECMO, the hepatic artery and the portal vein filling was poor at the ECMO perfusion level of <2.0 L/minute, but it was satisfactory at 2.0 to 3.0 L/minute.…”

Section: Resultsmentioning

confidence: 93%

Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation

et al. 2016

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Extracorporeal membrane oxygenation (ECMO) has been used to support brain-dead donors for liver procurement. This study investigated the potential role of ultrasonographic monitoring of hepatic perfusion as an aid to improve the viability of liver transplants obtained from brain-dead donors who are supported on ECMO. A total of 40 brain-dead patients maintained on ECMO served as the study population. Hepatic blood flow was monitored using ultrasonography, and perioperative optimal perfusion was maintained by calibrating ECMO. Liver function tests were performed to assess the viability of the graft. The hepatic arterial blood flow was well maintained with no significant changes observed before and after ECMO (206 6 32 versus 241 6 45 mL/minute; P 5 0.06). Similarly, the portal venous blood flow was also maintained throughout (451 6 65 versus 482 6 77 mL/minute; P 5 0.09). No significant change in levels of total bilirubin, alanine transaminase, and lactic acid were reported during ECMO (P 5 0.17, P 5 0.08, and P 5 0.09, respectively). Before the liver is procured, ultrasonographic monitoring of hepatic blood flow could be a valuable aid to improve the viability of a liver transplant by allowing for real-time calibration of ECMO perfusion in brain-dead liver donors. In our study, ultrasonographic monitoring helped prevent warm ischemic injury to the liver graft by avoiding both overperfusion and underperfusion of the liver. Liver Transpl 22: [188][189][190][191] 2016. V C 2015 AASLD.

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Section: Resultsmentioning

confidence: 93%

Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation

et al. 2016

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“…Thus, obstruction occurs in the whole process from cholesterol synthesis to plasma lipoproteins processing and assembling, and the level of TC is much lower than that of normal condition (18,19). Meanwhile, liver is also the main place for human protein metabolism, and can synthesize amino acid into protein that human body needs, such as ALB (20). Once ALB is synthesized in rough surfaced endoplasmic reticulum of hepatic cells, it is secreted to sinus hepaticas by Golgi body.…”

Section: Resultsmentioning

confidence: 98%

Insect tea extract attenuates CCl4-induced hepatic damage through its antioxidant capacities in ICR mice

Liao¹,

Zou

Wang

2016

Food Sci Biotechnol

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The Insect tea extract (ITE) contained many polyphenols, the aim of the present study was to determine the preventive effects of ITE on CCl-induced hepatic damage in mice. ITE treated mice could reduce hepatic injury compared to the control mice. The 200 mg/kg ITE increased TC, ALB, SOD, CAT, GSH-Px serum levels, and decreased ALT, AST, ALP, TG, BUN, NO, MDA levels compared to the control group. By histological observation, ITE reduced injury to hepatic cells, and these effects were close to that seen with the drug silymarin. The antioxidant related mRNA and protein expressions of Mn SOD, Gu/Zn SOD, CAT, and GSH-Px increased with ITE treatment in hepatic damage mice. ITE treated mice also showed higher IκB-α mRNA and protein expression, and lower NF-κB-p65, iNOS, COX-2 expressions than those of control mice. These results proved ITE has a prophylactic effect in protecting against hepatic injury through the antioxidant capacities.

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“…There were 15 patients with nonalcoholic fatty liver (NAFL) who had no fibrosis and inflammatory cell infiltration. The patients with NASH were evaluated on the basis of Brunt’s classification [ 21 , 46 , 47 ], while those with CHC were evaluated on the basis of Desmet’s classification [ 22 ]. Staging fibrosis in NASH based on Brunt’s classification: Stage 1: zone 3 perivenular perisinusoidal/pericellular fibrosis, focal or extensive; Stage 2: as above with focal or extensive periportal fibrosis; Stage 3: bridging fibrosis, focal or extensive; and Stage 4: cirrhosis.…”

Section: Methodsmentioning

confidence: 99%

“…However, few reports have addressed the association between HBF and liver function; no report has examined the progression of liver function according to the etiology of CLD. Moreover we previously reported that hepatic TBF in patients with liver cirrhosis varied according to the etiology of the disease and there is a close correlation between liver function and hepatic blood flow in patients with alcoholic liver cirrhosis [ 21 , 22 ]. In the present study, we investigated the difference in the fibrosis markers between patients with initial chronic hepatitis and those with advanced chronic hepatitis in NASH and CH-C.…”

Section: Introductionmentioning

confidence: 99%

Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus

Shigefuku

Takahashi

Nakano

et al. 2016

IJMS

Self Cite

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The progression of chronic liver disease differs by etiology. The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). It is important to recognize the difference between NAFLD and CHC. We concluded that changes in hepatic blood flow occurred during the earliest stage of hepatic fibrosis in patients with NAFLD; therefore, patients with NAFLD need to be followed carefully.

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Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis

Abstract: Our investigation showed that there is a close correlation between liver function and hepatic blood flow.

Cited by 25 publications

References 31 publications

Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation

Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation

Insect tea extract attenuates CCl4-induced hepatic damage through its antioxidant capacities in ICR mice

Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus

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