Correlation between cortical plaque count and neuronal loss in the nucleus basalis in Alzheimer's disease

Arendt, Thomas; Bigl, Volker; Tennstedt, A; Arendt, A

doi:10.1016/0304-3940(84)90292-1

Cited by 82 publications

(34 citation statements)

References 13 publications

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“…It has been described that in AD, AChE expression is substantially altered and its activity is decreased in most brain regions. However, the AChE activity is increased within and around the amyloid plaques [70]. Our study showed the contrary, that is, in the hippocampus and cortex there was a decrease of the AChE activity in the presence of Al, which would be a precursor of AD.…”

Section: Discussioncontrasting

confidence: 59%

Silicon Reverses Lipid Peroxidation but not Acetylcholinesterase Activity Induced by Long-Term Exposure to Low Aluminum Levels in Rat Brain Regions

Noremberg

Bohrer

Schetinger

et al. 2015

Biol Trace Elem Res

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Aluminum (Al) is the most widely distributed metal in the environment and is extensively used in daily life leading to easy exposure to human beings. Besides not having a recognized physiological role, Al may produce adverse effects through the interaction with the cholinergic system contributing to oxidative stress. The present study evaluated, in similar conditions of parenteral nutrition, whether the reaction of silicon (SiO2) with Al(3+) to form hydroxyaluminosilicates (HAS) reduces its bioavailability and toxicity through intraperitoneal administrations of 0.5 mg Al/kg/day and/or 2 mg Si/kg/day in Wistar rats. Al and Si concentrations were determined in rat brain tissue and serum. Acetylcholinesterase (AChE) activity and lipid peroxidation (LPO) were analyzed in the cerebellum, cortex, hippocampus, striatum, hypothalamus, and blood. An increase in the Al concentration was verified in the Al + Si group in the brain. All the groups demonstrated enhanced Si compared to the control animals. Al(3+) increased LPO measured by thiobarbituric acid reactive substances (TBARS) in cerebellum and hippocampus, whereas SiO2 reduced it when compared with the control group. An increase of AChE activity was observed in the Al-treated group in the cerebellum whereas a decrease of this enzyme activity was observed in the cortex and hippocampus in the Al and Al + Si groups. Al and Si concentrations increased in rat serum; however, no effect was observed in blood TBARS levels and AChE activity. SiO2 showed a protective effect in the hippocampus and cerebellum against cellular damage caused by Al(3+)-induced lipid peroxidation. Thus, SiO2 may be considered an important protector in LPO induced by Al(3+).

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Section: Discussioncontrasting

confidence: 59%

Silicon Reverses Lipid Peroxidation but not Acetylcholinesterase Activity Induced by Long-Term Exposure to Low Aluminum Levels in Rat Brain Regions

Noremberg

Bohrer

Schetinger

et al. 2015

Biol Trace Elem Res

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“…At postmortem, the nucleus basalis of Meynert (NBM), the major source of cholinergic innervation to the hippocampus and cortex, shows dramatic degeneration [10]. Furthermore, reduction in choline acetyl transferase activity, the hallmark of cholinergic neurons, is substantially reduced in postmortem studies of AD and bears a correlation to the degree of dementia [2,11,12]. Studies from biopsy specimens, cerebrospinal fluid studies, and in vivo pharmacologic challenge studies have supported that the cholinergic pathway is affected in AD [13Y16].…”

Section: Cholinergic Pathwaymentioning

confidence: 98%

The Application of Positron-Emitting Molecular Imaging Tracers in Alzheimer’s Disease

Cohen

2007

Mol Imaging Biol

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The symptomatology and known pathology of Alzheimer's disease are restricted to the central nervous system. This review details studies of PET tracers aimed at interrogating cholinergic, serotonergic, opiate, benzodiazepine, and inflammatory pathways as well as PET tracers that illuminate amyloid plaques and neurofibrillary tangles in AD. Progress has been remarkable. Together with studies of brain structure with MRI and of functional regional brain activity, e.g., through measures of blood flow and glucose metabolic rate, molecular imaging promises to dramatically alter our understanding of the structural and physiological abnormalities underlying AD symptomatology. A more immediate impact on the diagnosis and treatment evaluation of AD patients in clinical trials is predicted while the possibility of personalized treatment or prevention of AD may not be that far away.

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“…Besides the fact that Al is a cholinotoxin agent, its neurotoxic effects could be exerted by further mechanisms including the generation of oxidative stress [5]. The increased production of the AChE may be due to a direct action of Aβ, which binds to nicotinic receptors or overexpression of APP and consequently Aβ induced by Al results in the increased activity of AChE within and around Aβ plaques [2,91].…”

Section: Controlmentioning

confidence: 99%

The Role of Mental and Physical Activities against Development of Alzheimer ’s Disease in Socialized and Isolated Rats

Ali¹,

Khalil²,

Elariny³

et al. 2017

Brain Disord Ther

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Correlation between cortical plaque count and neuronal loss in the nucleus basalis in Alzheimer's disease

Cited by 82 publications

References 13 publications

Silicon Reverses Lipid Peroxidation but not Acetylcholinesterase Activity Induced by Long-Term Exposure to Low Aluminum Levels in Rat Brain Regions

Silicon Reverses Lipid Peroxidation but not Acetylcholinesterase Activity Induced by Long-Term Exposure to Low Aluminum Levels in Rat Brain Regions

The Application of Positron-Emitting Molecular Imaging Tracers in Alzheimer’s Disease

The Role of Mental and Physical Activities against Development of Alzheimer ’s Disease in Socialized and Isolated Rats

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