Correlation between 25-hydroxy vitamin D levels and COVID-19 severity in pregnant women: a cross-sectional study

Seven, Banu; Gündüz, Özlem; Özgü-Erdinç, A. Seval; Şahın, Dilek; Tekın, Özlem Moraloğlu; Keskin, Hüseyin Levent

doi:10.1080/14767058.2021.2005564

Cited by 9 publications

(19 citation statements)

References 30 publications

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“…These findings were indirectly confirmed by another study, which evaluated 15 SARS-CoV-2 positive pregnant women (7 asymptomatic and 8 mildly symptomatic) and 20 healthy pregnant controls and showed that vitamin D deficiency (<20 ng/mL) was present in all pregnant women but with lower levels (<12 ng/mL) found in pregnant women with mild COVID-19 [17]. Similarly, other studies reported lower 25-vitamin D levels in SARS-CoV-2 positive pregnant women, also suggesting vitamin D supplementation during the gestation [17,18].…”

Section: Discussionmentioning

confidence: 77%

Pregnancy and COVID-19: The Possible Contribution of Vitamin D

et al. 2022

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Background: Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients. Methods: Vitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL. Results: In total, 160 women were enrolled: 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positive subjects: remarkably, all the VDR TaqICC genotype patients were negative for SARS-CoV-2. In a sub-population (118 patients), vitamin D levels correlated with pregnancy-related factors, such as alpha-fetoprotein levels. Third-trimester vitamin D levels were lower in preterm births compared to full-term pregnancy: this trend was highlighted for SARS-CoV-2 positive patients. Conclusions: This is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings.

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Section: Discussionmentioning

confidence: 77%

Pregnancy and COVID-19: The Possible Contribution of Vitamin D

et al. 2022

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“…Out of seven included studies, five utilized a caseecontrol design [20e22, 27,28], one study used a retrospective cohort analysis [29], and one was in a cross-sectional manner [30].…”

Section: Description Of Included Studiesmentioning

confidence: 99%

“…The normal range of vitamin D is considered to be above 30 ng/ml in all studies except one study in Turkey by Tekin et al, which considered amounts above 50 ng/ml as an optimal serum concentration [20]. Four studies were conducted in Turkey [20,21,27,30], two in Spain [22,28], and one in France [29]. Based on the NIH quality assessment tool, six studies [20e22,28e30] possessed good quality, and one study qualified as fair [27].…”

Section: Description Of Included Studiesmentioning

confidence: 99%

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Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis

Mazaheri‐Tehrani¹,

Mirzapour²,

Yazdi³

et al. 2022

Clinical Nutrition ESPEN

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“…With interest, we read the paper of Seven et al [1], which showed significantly lower 25hydroxy vitamin D [25(OH)D] levels in pregnant women with severe Coronavirus disease 19 (COVID-19) and/or poor prognostic factors. We would like to discuss the potential influence of the vitamin D binding protein (DBP) and its polymorphism on the reported results.…”

mentioning

confidence: 99%