2019
DOI: 10.1177/1120672119833267
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Abstract: Purpose: The aim of this study was to evaluate the correlations between fundus autofluorescence and morphologic parameters as well as visual function in patients with diabetic macular oedema treated with intravitreal ziv-aflibercept. Methods: A total of 34 eyes of 20 patients with untreated diabetic macular oedema received an intravitreal injection of ziv-aflibercept at baseline, and 1 and 2 months later. The baseline, 1-month, and two-month best corrected visual acuity determination, contrast sensitivity, spe… Show more

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Cited by 8 publications
(21 citation statements)
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References 21 publications
(34 reference statements)
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“…FAF was found to correlate better with OCT patterns and central field microperimetry rather than with visual acuity. 106 An increased FAF signal (hyper-autofluorescence) is associated with worsening visual acuity and an increase in the macular thickness on OCT. 113 In patients with DME, the pretreatment baseline degree of foveal FAF signal might be helpful in predicting macular cube average thickness in patients undergoing treatment with intravitreal anti-VEGF in the short term. 112 Thus, apart from assessing the health of the RPE, FAF may have several applications in subjects with DR and DME.…”
Section: Fundus Autofluorescence Biomarkersmentioning
confidence: 99%
“…FAF was found to correlate better with OCT patterns and central field microperimetry rather than with visual acuity. 106 An increased FAF signal (hyper-autofluorescence) is associated with worsening visual acuity and an increase in the macular thickness on OCT. 113 In patients with DME, the pretreatment baseline degree of foveal FAF signal might be helpful in predicting macular cube average thickness in patients undergoing treatment with intravitreal anti-VEGF in the short term. 112 Thus, apart from assessing the health of the RPE, FAF may have several applications in subjects with DR and DME.…”
Section: Fundus Autofluorescence Biomarkersmentioning
confidence: 99%
“…We read the article by Hernandez-Da Mota et al 1 with great interest. We have some criticism regarding some technical issues.…”
mentioning
confidence: 99%
“… 20 , 22 Furthermore, an increased signal of FAF has been associated with increased macular thickness as well. 9 , 11 When an intraretinal cyst forms in the fovea, the fluid contained within displace laterally the retinal tissue and the macular pigments. This retinal tissue displacement enables the detection of the FAF signal coming from the retinal pigment epithelium, enhancing its detection despite the presence of DME.…”
Section: Discussionmentioning
confidence: 99%
“…FAF patterns were classified into five different stages or grades based on the modification of two separate autofluorescence classification systems published elsewhere. 9 , 11 …”
Section: Methodsmentioning
confidence: 99%