Correction: Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS

Smirnov, V. V.; Beeraka, Narasimha M; Butko, Dmitry Yu.; Николенко, В.Н.; Bondarev, Sergey; Ачкасов, Е Е; Sinelnikov, Mikhail Y.; Vikram, P. R. Hemanth

doi:10.1007/s43032-022-01035-5

Cited by 2 publications

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“…See table 1 and figure 2 and 3. PCOS is most common disorders of females caused by cyst formation in ovarian that results defect at hormones secretion and menstrual cycle (6). PCOS causes are various but the mainly cause is increase of BMI (obesity) (7).…”

Section: Resultsmentioning

confidence: 99%

Assessment of Neuregulin4 function in patients with polycystic ovary syndrome disorder

Al-Dahy¹,

Almusawi²,

Ballur³

2022

Journal of Pharmaceutical Negative Results

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Subject: Polycystic ovary syndrome (PCOS) is female disorder caused by cysts formation in ovarian that results disorder of hormones secretion and menstrual cycle. Neuregulin 4 (NRG4) is one of adipokines family members synthesis and release via adipose tissues, it acts as activator the epidermal growth factor receptor (EGFR).Objective of the Study: Assessment role of NRG4 in PCOS patients.Materials and Methods: Present study included 30 PCOS patients with 30 controls, the age individuals of tow group at study were 18 years and above of females. At this study measured serum NRG4 level by quantity method for all study individuals, the body mass index (BMI) also measured for all study individuals.Results: Present study explain increase of NRG4 level in serum samples and BMI in PCOS patients group compared with control group.Conclusion: Current study demonstrate role of NRG4 level that act as compensate mechanism in PCOS disorder.

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Section: Resultsmentioning

confidence: 99%

Assessment of Neuregulin4 function in patients with polycystic ovary syndrome disorder

Al-Dahy¹,

Almusawi²,

Ballur³

2022

Journal of Pharmaceutical Negative Results

View full text Add to dashboard Cite

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Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

Szukiewicz

Trojanowski

Kociszewska

et al. 2022

IJMS

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Despite its incidence, the syndrome is poorly understood and remains underdiagnosed, and female patients are diagnosed with a delay. The heterogenous nature of this complex disorder results from the combined occurrence of genetic, environmental, endocrine, and behavioral factors. Primary clinical manifestations of PCOS are derived from the excess of androgens (anovulation, polycystic ovary morphology, lack of or scanty, irregular menstrual periods, acne and hirsutism), whereas the secondary manifestations include multiple metabolic, cardiovascular, and psychological disorders. Dietary and lifestyle factors play important roles in the development and course of PCOS, which suggests strong epigenetic and environmental influences. Many studies have shown a strong association between PCOS and chronic, low-grade inflammation both in the ovarian tissue and throughout the body. In the vast majority of PCOS patients, elevated values of inflammatory markers or their gene markers have been reported. Development of the vicious cycle of the chronic inflammatory state in PCOS is additionally stimulated by hyperinsulinemia and obesity. Changes in DNA methylation, histone acetylation and noncoding RNA levels are presented in this review in the context of oxidative stress, reactive oxygen species, and inflammatory signaling in PCOS. Epigenetic modulation of androgenic activity in response to inflammatory signaling is also discussed.

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Correction: Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS

Cited by 2 publications

References 0 publications

Assessment of Neuregulin4 function in patients with polycystic ovary syndrome disorder

Assessment of Neuregulin4 function in patients with polycystic ovary syndrome disorder

Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

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