2020
DOI: 10.1186/s12974-020-01872-8
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Abstract: An amendment to this paper has been published and can be accessed via the original article.

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Cited by 39 publications
(16 citation statements)
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“…As it was reported previously, PTEN gene is one of the main negative regulators of PI3K/Akt pathway, and inhibition of PTEN can facilitate intrinsic regenerative outgrowth of adult peripheral axons [42]; from well-documented papers, we screened out several miRs that implicated with PTEN downregulation and neuronal repair. The literature on EVs suggested that miR candidates, such as miR-19b [43], miR-21 [40], miR-29b-3p [44], miR-233 [45], and miR-304-5p [46], would enable the activation of PI3K and downstream signaling molecules.…”
Section: Discussionmentioning
confidence: 99%
“…As it was reported previously, PTEN gene is one of the main negative regulators of PI3K/Akt pathway, and inhibition of PTEN can facilitate intrinsic regenerative outgrowth of adult peripheral axons [42]; from well-documented papers, we screened out several miRs that implicated with PTEN downregulation and neuronal repair. The literature on EVs suggested that miR candidates, such as miR-19b [43], miR-21 [40], miR-29b-3p [44], miR-233 [45], and miR-304-5p [46], would enable the activation of PI3K and downstream signaling molecules.…”
Section: Discussionmentioning
confidence: 99%
“…Transfection of miR-184 and miR-210 into neural stem cells and human umbilical vein endothelial cells could increase the proliferation of these two cells, suggesting that MSC-EVs may induce the proliferation of vascular endothelial cells and neural stem cells after IS through miR-184 and miR-210 [93]. Secondly, MSC-EVs containing miR-29b-3p inhibitor could increase the apoptosis of oxygen-glucose-deprived neurons and decrease the angiogenesis of BMEC, while MSC-EVs overexpressing miR-29b-3p had the opposite effect [90]. This suggests that miR-29b-3p may mediate the neuroprotective and angiogenic effects of MSC-EVs.…”
Section: Mitochondrial Transfermentioning
confidence: 98%
“…By coculturing MSCs with OGD neurons and brain microvascular endothelial cells (BMEC), the researchers found that the former could reduce the apoptosis of damaged neurons and restore the tube formation of BMEC [90]. The addition of GW4869 (an inhibitor of EVs secret) can reverse this beneficial effect, which suggests that MSC-EVs may be the main mediator of the neuroprotective and angiogenic effects of MSCs [90]. Xin et al injected rats with MSCs-EVs via the tail vein 24 hours after the induction of IS [91].…”
Section: Mitochondrial Transfermentioning
confidence: 99%
“…Recently, a number of studies have confirmed the therapeutic effectiveness of EV-mediated miRNA delivery in ischemic stroke. Plenty of miRNAs were involved in these processes, such as miRNA-29b-3p and miRNA-26b-5p (Hou et al, 2020;Li et al, 2020a). However, more researchers used miRNAs to modify MSCs for producing more robust EVs.…”
Section: Msc-derived Ev-mediated Mirna Transfer and Neuroinflammationmentioning
confidence: 99%