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Cited by 6 publications
(3 citation statements)
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“…SIRT4 overexpression in lung cancer‐derived cell lines results in more fused mitochondria and reduced mitochondrial fission via downregulation of DRP1 expression and inhibition of Ser 616 phosphorylation . Further evidence for SIRT4 regulation of mitochondrial dynamics comes from another in vitro study in cell lines in which SIRT4 overexpression was observed to drive mitochondrial fusion and was associated with an enrichment of L‐OPA1, the fusion‐promoting long form of OPA1, relative to S‐OPA1 . The authors found that SIRT4 directly interacts with OPA1, but the particular mechanism remains unclear.…”
Section: Introductionmentioning
confidence: 99%
“…SIRT4 overexpression in lung cancer‐derived cell lines results in more fused mitochondria and reduced mitochondrial fission via downregulation of DRP1 expression and inhibition of Ser 616 phosphorylation . Further evidence for SIRT4 regulation of mitochondrial dynamics comes from another in vitro study in cell lines in which SIRT4 overexpression was observed to drive mitochondrial fusion and was associated with an enrichment of L‐OPA1, the fusion‐promoting long form of OPA1, relative to S‐OPA1 . The authors found that SIRT4 directly interacts with OPA1, but the particular mechanism remains unclear.…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, SIRT4, as a mitochondrial protein [33], has attracted increasing attention for its role in regulating tumor energy metabolism. SIRT4 was involved in regulating glutamine metabolism by inhibiting glutamate dehydrogenase (GDH) [34], glucose metabolism by inhibiting pyruvate dehydrogenase complex (PDH) [35] and lipid metabolism by targeting malonyl-CoA decarboxylase (MCD) [36].…”
Section: Discussionmentioning
confidence: 99%
“…SIRT4 is localized to mitochondria. Interestingly, SIRT4 expression may promote stress-induced autophagic flux, but also decrease PINK1/Parkin-associated mitophagy, leading to an increase of mitochondrial content (Lang et al, 2018 ). SIRT4 activation shifts mitochondrial fusion, resulting in the downregulation of mitophagy during aging via the GTPase OPA1 (L-OPA1), which promotes mitochondrial fusion (Lang et al, 2018 ).…”
Section: Methodsmentioning
confidence: 99%