Correction of Microstomia Reconstruction With the Use of Acellular Dermal Matrix for Buccal Reconstruction

Wood, Benjamin C.; Mantilla-Rivas, Esperanza; Goldrich, Agnes; Boyajian, Michael J.; Oh, Albert K.; Rogers, Gary F.

doi:10.1097/scs.0000000000005182

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…There are studies in the literature with Dermal Matrix showing good results, reducing scar retraction in human adults. 10,11,[27][28][29][30][31][32] Schmitt suggests that the Mucograft ™ (Geistlich Pharma AG, Wolhusen, Switzerland) ® membrane is a promising alternative for the regeneration of keratinized mucosa and is a sufficient substitute for the free gingival graft. 10,11 The dermal matrix was designed for soft tissue regeneration as an alternative to autogenous free gingival graft and connective tissue graft.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical techniques that cover the denuded palatine bone by replacing the mucosa with autogenous grafts from the face, palate, and periosteum or by oral mucosal membranes obtained through tissue engineering have been tested to promote better healing and have beneficial effects. [27][28][29][30][31][32] Theoretical disadvantages of DM in comparison to autologous grafts are risk of infection, transmission of disease, cost factor and lastly religious diversity.…”

Section: Discussionmentioning

confidence: 99%

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Dermal Matrix Graft Effects on Facial Growth in a Veau–Wardill–Kilner Palatoplasty Model: An Experimental Study in Rats

Zanin

Arpini

Roth

et al. 2022

The Cleft Palate Craniofacial Journal

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The primary goal of palatoplasty is the restoration of normal speech, that can be aimed by, among many procedures, lengthening the palate through the pushback technique; one of its complications is abnormal maxillary growth. The main factor affecting facial growth in CLP patients is believed by many to be the palatoplasty—due to the large scar retraction resulting from some surgical techniques. The non-crosslinked two-layer bioabsorbable collagen matrix Mucograft™ (Geistlich Pharma AG, Wolhusen, Switzerland) is a potential tool to aid in wound closure in a second-intention healing situation. The objective of this work was to test the use of an acellular dermal matrix (Mucograft®) in an experimental model of Veau–Wardill–Kilner palatoplasty, as a tool to reduce scar retraction of the denuded palatine mucosa. Twenty-four 3-week-old male Wistar rats were used. The animals were randomly divided into two groups. In the control group, an excision was made with bone exposure in the palate, simulating the defect left in the Veau–Wardill–Kilner palatoplasty. In the intervention group, the same procedure was performed, and the area of denuded palatine bone was treated with a bioabsorbable collagen matrix (Mucograft®). For data collection, 9 weeks after surgery (12 weeks of life), the animals were euthanized by excessive anesthetic dosage. Maxillary growth, macroscopic appearance of the scar, pain, and bleeding were evaluated. There were significant statistical differences between the groups for palate length growth (7.6 mm + −0.38 mm vs 5.5 mm + −0.36 mm, P = .009) and for palate width growth (1.47 mm + −0.8 mm vs −0.09 mm + −0.55 mm, P = .001), favoring dermal matrix group compared to controls. Whereas for pain and bleeding, there were no differences between the groups. The use of dermal matrix in rats with an area of bone denudation on the palate increases maxillary length and width growth patterns. Besides, it does not increase pain, bleeding, or post-operative complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dermal Matrix Graft Effects on Facial Growth in a Veau–Wardill–Kilner Palatoplasty Model: An Experimental Study in Rats

Zanin

Arpini

Roth

et al. 2022

The Cleft Palate Craniofacial Journal

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“…The applications of ADMs in reconstructive surgery have become quite common over the past 20 years. ADMs are currently far more used in reconstructive surgery than in burns, as a soft tissue implant for augmentation and reconstruction of different body areas such as: tympanic membrane (23), cleft palate (24), dura mater (25), nose (26), lips (27), chest (28), abdominal wall (29), upper and lower extremities (30,31), pelvis etc. (32,33,34).…”

Section: Clinical Applications and Indications Of Admsmentioning

confidence: 99%

Preparation and processing of human allogenic dermal matrix for utilization in reconstructive surgical procedures

Sarkozyova¹,

Dragúňová²,

Bukovčan³

et al. 2020

BLL

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AIM: This article presents the development of a novel preparation and processing method as well as indication for clinical applications of human allogeneic acellular dermal matrix, which was developed originally in the Central Tissue Bank (CTB) for use in burn medicine and reconstructive surgery. METHODS: Acellular dermal matrix (ADM) is a biological material assigned for utilization in several surgical procedures due to its unique structure and advantageous properties. The article focuses on a novel preparation and processing method developed by CTB, which differs in its impact on the structure, biological and biomechanical properties of the fi nal ADM compared to the wide range of commercially available ADM products and currently available ADM products of other tissue banks. RESULTS: The ubiquitous acellular allogeneic dermal collagen matrix is the main substance participating in advantageous properties facilitating the use of ADM in numerous indications from dermal replacement and soft tissue augmentation to more extensive surgical reconstructive procedures. Dermal substitutes play an essential role in the reconstruction of full-thickness skin defects, both in acute and chronic wounds, defects of fasciae, peritoneum, etc., and there is a strong evidence that they can improve the fi nal scar quality as well. Differences in preparation methods of ADMs are recently causing concerns among surgeons utilizing the ADMs. We present three different cases with favourable outcomes by using human acellular ADM grafts. CONCLUSIONS: Although ADMs did not fulfi l all of the requirements for an ideal dermal substitute, their applications have been advanced for diverse indications in soft tissue reconstructions and augmentations. Early revascularization of the allografts reduces bacterial contamination. Research and development of new generation of acellular dermal matrices with incorporated autologous in vitro cultured cells will likely yield new products and give new hope for continued improve ments in functional and cosmetic outcomes (Fig. 9, Ref. 60).

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Correction of Microstomia Reconstruction With the Use of Acellular Dermal Matrix for Buccal Reconstruction

Cited by 2 publications

References 29 publications

Dermal Matrix Graft Effects on Facial Growth in a Veau–Wardill–Kilner Palatoplasty Model: An Experimental Study in Rats

Dermal Matrix Graft Effects on Facial Growth in a Veau–Wardill–Kilner Palatoplasty Model: An Experimental Study in Rats

Preparation and processing of human allogenic dermal matrix for utilization in reconstructive surgical procedures

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