Correction of Hormonal and Metabolic Disorders in Male Rats with Developing Experimental Diabetes

Didebulidze, Neli; Kakabadze, Manana; Gordadze, N. G.; Latsabidze, Irakli; Kordzaya, M. E.; Sikharulidze, I

doi:10.1007/s10517-015-2879-8

Cited by 1 publication

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“…Later, the fragments were rinsed in cold (+4ºС) nourishing buffer with subsequent homogenization and placement in scintillating fluid container vials (according to previously published recommendations (Didebulidze, et al, 2015. The frequency (quantity) of radioactive impulses (imp/gr/min) was calculated by the "β-2" device (produced by the Enterprise of Academy of Medical Sciences, Russia).…”

Section: Measurement Of Hepatic Dna/rna Contentmentioning

confidence: 99%

Effect of Methyltrienolone on the Metabolic Disorders in Rat Model of Alloxan-Induced Diabetes

MBiol¹,

Kandelaki²,

Kakabadze³

et al. 2017

ESJ

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Aim: The aim of the study was to investigate the restoration of metabolic imbalance related with deficiency of insulin by the exogenous androgen supplementation in the experimental model of alloxan-induced diabetes in Wistar male rats. Methods: The experimental diabetes was induced by a single intraperitoneal administration of alloxan. The concentrations of glucose, immunereactive insulin, corticosterone, testosterone and estradiol were examined in blood, the intensity of DNA and RNA synthesis and androgen receptor expression were studied in the liver Results:The induction of diabetes increased the concentrations of glucose, corticosterone and estradiol while decreases insulin and testosterone concentration in blood as well as DNA/RNA synthesis and androgen receptors expression in hepatocytes. The administration of exogenous androgen significantly restored the metabolic imbalance and the expression of androgen receptors and increased DNA/RNA synthesis in liver cells maintained close to control level. Conclusion: The administration of methyltrienolone reduced the effect of "diabetic stress" and restored the hormonal dysfunction induced by alloxan.

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Section: Measurement Of Hepatic Dna/rna Contentmentioning

confidence: 99%