Correction: LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway

Wang, Tianfu; Hao, Zhiyu; Liu, Changcheng; Yuan, Lebin; Li, Li; Yin, Menghong; Li, Qing; Qi, Zhiming; Wang, Zi

doi:10.1038/s41419-020-02852-9

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Osteoarthritis (Oa)1

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2024

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“…Functional analysis revealed that circRNF121 and MYD88 are involved in the modulation of ECM degradation, apoptosis, and proliferation of chondrocytes. OA progression takes place by promoting ECM degradation through circRNF121/miR-665/MYD88 axis via the NF-кB pathway [74]. Zhang et al explored the role of CircRNA-CDR1as in ECM degradation via sponging miR-641 [75].…”

Section: Osteoarthritis (Oa)mentioning

confidence: 99%

Interplay between circular RNA, microRNA, and human diseases

Kour,

Gupta,

Singh

et al. 2024

Preprint

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Circular RNAs (circRNAs) are endogenous RNA formed by the back splicing process. They are ubiquitous, stable, evolutionally conserved, and are tissue-specific. CircRNAs have numerous latent modes of action, from acting as sponges for microRNAs and RNA binding proteins to serving as transcriptional regulators, epigenetic alterations, etc. Dysregulated functioning of several circular RNAs leads to the progression of a plethora of diseases. CircRNAs have paved the way for advanced clinical studies as a novel method of disease diagnosis. This review systematically summarized and evaluated the role of differentially expressed circRNAs in four human diseases, including neurodegenerative diseases, diabetes, osteoarthritis, and cardiovascular diseases.

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Section: Osteoarthritis (Oa)mentioning

confidence: 99%