Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy

Middelburg, Tom A.; Hoy, Christopher L.; Neumann, H. A. M.; Amelink, Arjen; Robinson, Dominic J.

doi:10.1016/j.jdermsci.2015.03.017

Cited by 26 publications

(31 citation statements)

References 68 publications

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“…These optical tissue parameters need to be considered carefully, before the resulting measured intensity can be taken to represent PpIX concentration as an absolute value. Methods to correct for optical tissue parameters have for example, been proposed by a group in Rotterdam and suggestions for implementation into surgical microscopes have been made by Valdes et al and Xie et al . An intriguing technology to obtain quantitative fluorescence imaging is using spatially modulated light at the excitation and emission wavelengths to retrieve absorption and scattering parameters to further correct fluorescence images and even to reconstruct 3D distributions of PpIX .…”

Section: Fluorescence Guided Surgerymentioning

confidence: 99%

5‐ALA in the management of malignant glioma

Stepp¹,

2018

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Background: Patients suffering from malignant gliomas have a poor prognosis. For the surgical treatment of these tumors, 5-aminolevulinic acid (5-ALA) has become a new standard. Aims: This review intends to provide an overview over current status, significance, limitations, and future perspectives of 5-ALA based fluorescence guided surgery and photodynamic therapy for brain tumor patients. Materials and Methods: From peer reviewed publications on the many aspects connected with this topic, those with potential clinical relevance were selected and put in the context of our own experience. Results and Discussion: The high tumor selectivity of accumulation of fluorescent protoporphyrin IX (PpIX) after systemic administration of 5-ALA enables intra-operative fluorescence guidance, which is unimpaired by brainshift and does not require expensive equipment. The neurosurgical aim of complete resection of enhancing tumor can now more easily be achieved, which improves prognosis in these patients. Nevertheless, despite better surgery tumors will inevitably recur. In order to further prolong survival, the phototoxic properties of PpIX are presently being exploited in clinical trials of post-operative or interstitial photodynamic therapy (PDT). Conclusion: 5-ALA based fluorescence guidance and PDT offer an intriguing new option for the management of malignant gliomas. Lasers Surg. Med. 50:399-419, 2018.

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Section: Fluorescence Guided Surgerymentioning

confidence: 99%

5‐ALA in the management of malignant glioma

Stepp¹,

2018

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“…Corrections have been attempted by collecting reflectance images in addition to the white light and fluorescence images and performing multi-diameter single-fiber reflectance and single-fiber fluorescence (MDSFR/SFF) spectroscopy. 53,56,59 This latter technique can correct for the absorption and scattering of tissue and thus accurately quantify the intrinsic fluorescence signals, which is most likely essential for individualized treatment decisions.…”

Section: Pitfalls and Challenges For Implementation Of Molecular Imagmentioning

confidence: 99%

“…NIR wavelengths penetrate deeper into the target tissue and are less subjected to interference by hemoglobin absorption, autofluorescence signals, and tissue scattering. 53 However, NIR fluorescence leads to significant technical challenges in the design of clinical endoscopes for the detection of fluorescence.…”

Section: Introductionmentioning

confidence: 99%

Novel Developments in Endoscopic Mucosal Imaging

2018

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Endoscopic techniques such as high-definition and optical-chromoendoscopy have had enormous impact on endoscopy practice. Since these techniques allow assessment of most subtle morphological mucosal abnormalities, further improvements in endoscopic practice lay in increasing the detection efficacy of endoscopists. Several new developments could assist in this. First, web based training tools could improve the skills of the endoscopist for enhancing the detection and classification of lesions. Secondly, incorporation of computer aided detection will be the next step to raise endoscopic quality of the captured data. These systems will aid the endoscopist in interpreting the increasing amount of visual information in endoscopic images providing real-time objective second reading. In addition, developments in the field of molecular imaging open opportunities to add functional imaging data, visualizing biological parameters, of the gastrointestinal tract to white-light morphology imaging. For the successful implementation of abovementioned techniques, a true multi-disciplinary approach is of vital importance.

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“…These geometries cannot be simply approximated by a well-defined shape such as a hollow cylinder or sphere but require a more dedicated approach. In addition, the optical properties vary within the geometry and between patients (33)(34)(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

On the Development of a Light Dosimetry Planning Tool for Photodynamic Therapy in Arbitrary Shaped Cavities: Initial Results

Doeveren

Bouwmans

Wassenaar

et al. 2020

Photochem & Photobiology

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Previous dosimetric studies during photodynamic therapy (PDT) of superficial lesions within a cavity such as the nasopharynx, demonstrated significant intra‐ and interpatient variations in fluence rate build‐up as a result of tissue surface re‐emitted and reflected photons, which depends on the optical properties. This scattering effect affects the response to PDT. Recently, a meta‐tetra(hydroxyphenyl)chlorin‐mediated PDT study of malignancies in the paranasal sinuses after salvage surgery was initiated. These geometries are complex in shape, with spatially varying optical properties. Therefore, preplanning and in vivo dosimetry is required to ensure an effective fluence delivered to the tumor. For this purpose, two 3D light distribution models were developed: first, a simple empirical model that directly calculates the fluence rate at the cavity surface using a simple linear function that includes the scatter contribution as function of the light source to surface distance. And second, an analytical model based on Lambert’s cosine law assuming a global diffuse reflectance constant. The models were evaluated by means of three 3D printed optical phantoms and one porcine tissue phantom. Predictive fluence rate distributions of both models are within ± 20% accurate and have the potential to determine the optimal source location and light source output power settings.

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Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy

Cited by 26 publications

References 68 publications

5‐ALA in the management of malignant glioma

5‐ALA in the management of malignant glioma

Novel Developments in Endoscopic Mucosal Imaging

On the Development of a Light Dosimetry Planning Tool for Photodynamic Therapy in Arbitrary Shaped Cavities: Initial Results

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