Correction: Early Fluid Resuscitation by Lactated Ringer's Solution Alleviate the Cardiac Apoptosis in Rats with Trauma-Hemorrhagic Shock

Lin, Kuan-Ho; Liu, Chien‐Liang; Kuo, Wei‐Wen; Paul, Catherine Reena; Chen, Wei-Kung; Wen, Su‐Ying; Day, Cecilia Hsuan; Wu, Hsi‐Chin; Viswanadha, Vijaya Padma; Huang, Chih‐Yang

doi:10.1371/journal.pone.0168419

Cited by 2 publications

(2 citation statements)

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“…Moreover, H 2 S and the oxytocin (OT)/ oxytocin receptor (OTR) systems interact in trauma in the heart and the brain (11)(12)(13)(14)(15) and are both reported to have anti-oxidative, and vasculo-protective effects (15). Hence, activation of either system could be beneficial in HS, since severe hypovolemia can induce at least transitory cerebral tissue hypoxia events (16- 19), redox imbalance (20), barrier dysfunction (18,21) and, upon resuscitation, ischemia/reperfusion (I/R) injury (22).…”

Section: Introductionmentioning

confidence: 99%

Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na2S2O3) Treatment

et al. 2022

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BackgroundThe hydrogen sulfide (H2S) and the oxytocin/oxytocin receptor (OT/OTR) systems interact in the central nervous and cardiovascular system. As a consequence of osmotic balance stress, H2S stimulates OT release from the paraventricular nuclei (PVN) in the hypothalamic regulation of blood volume and pressure. Hemorrhagic shock (HS) represents one of the most pronounced acute changes in blood volume, which, moreover, may cause at least transient brain tissue hypoxia. Atherosclerosis is associated with reduced vascular expression of the main endogenous H2S producing enzyme cystathionine-γ-lyase (CSE), and, hence, exogenous H2S administration could be beneficial in these patients, in particular after HS. However, so far cerebral effects of systemic H2S administration are poorly understood. Having previously shown lung-protective effects of therapeutic Na2S2O3 administration in a clinically relevant, long-term, porcine model of HS and resuscitation we evaluated if these protective effects were extended to the brain.MethodsIn this study, available unanalyzed paraffin embedded brain sections (Na2S2O3N = 8 or vehicle N = 5) of our recently published HS study were analyzed via neuro-histopathology and immunohistochemistry for the endogenous H2S producing enzymes, OT, OTR, and markers for brain injury and oxidative stress (glial fibrillary acidic protein (GFAP) and nitrotyrosine).ResultsNeuro-histopathological analysis revealed uninjured brain tissue with minor white matter edema. Protein quantification in the hypothalamic PVN showed no significant inter-group differences between vehicle or Na2S2O3 treatment.ConclusionsThe endogenous H2S enzymes, OT/OTR co-localized in magnocellular neurons in the hypothalamus, which may reflect their interaction in response to HS-induced hypovolemia. The preserved blood brain barrier (BBB) may have resulted in impermeability for Na2S2O3 and no inter-group differences in the PVN. Nonetheless, our results do not preclude that Na2S2O3 could have a therapeutic benefit in the brain in an injury that disrupts the BBB, e.g., traumatic brain injury (TBI) or acute subdural hematoma (ASDH).

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Section: Introductionmentioning

confidence: 99%

Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na2S2O3) Treatment

et al. 2022

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“…Myocardial damage, known as a chronic disease, requires ongoing medical attention. So, THS can induce secondary cardiac injuries (10,11). These policies not only have resulted in reduced mortality rates attributable to the trauma and socioeconomic burden of the disease but also have improved the outcomes of patients (12,13).…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen Versus Fresh Frozen Plasma on the Patients’ Outcome with Hemorrhagic Shock Induce Chronic Diseases Caused by Multiple Trauma: A Randomized, Double-blinded, Clinical Trial Study

Moezzi

Mozafari

Barzegari

et al. 2021

Jundishapur J Chronic Dis Care

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Objectives: The current study aimed to investigate the effect of fibrinogen compared to fresh frozen plasma (FFP) on outcomes of patients with traumatic hemorrhagic shock (THS). Methods: In this double-blind RCT study, traumatic hemorrhagic shock patients with chronic diseases referred to the emergency department (ED) were evaluated. Patients were randomly divided into three equal groups; The first group received fibrinogen concentrate (70 mg/kg), the second group was treated with FFP, and the third group received crystalloid. Transfusion of FFP and packed red blood cells (PRBC) was in a 1:1 ratio. The need for admission in intensive care units, PRBC transfusion units, multiple organ failure, hospitalization days, and mortality rate were compared in both groups. Results: In total, 45 patients were studied. The number of red blood cells (RBCs) transfused in patients treated with crystalloid, FFP, and Fibrinogen was 2.93, 2.37, and 2, respectively, which was statistically significant (P = 0.03). Two patients (13.3%) in the Fibrinogen-treated group, 4 (26%) in the FFP group, and 2 in the control group had multiple organ failure (P = 0.5). The incidence of sepsis was significantly higher in the FFP-treated group. In addition, mortality was significantly higher in patients who received crystalloid (46.7%) (P = 0.13). Conclusions: This study demonstrated that treating patients with fibrinogen concentrate was associated with a decreased number of pRBC transfusion units and mortality. Therefore, management of traumatic patients with fibrinogen concentrate not only can improve the outcomes but also declines patients’ exposure to allogeneic blood products.

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Correction: Early Fluid Resuscitation by Lactated Ringer's Solution Alleviate the Cardiac Apoptosis in Rats with Trauma-Hemorrhagic Shock

Cited by 2 publications

References 1 publication

Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na2S2O3) Treatment

Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na2S2O3) Treatment

Fibrinogen Versus Fresh Frozen Plasma on the Patients’ Outcome with Hemorrhagic Shock Induce Chronic Diseases Caused by Multiple Trauma: A Randomized, Double-blinded, Clinical Trial Study

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