Correction: Ablation of Ca_V2.1 Voltage-Gated Ca²⁺Channels in Mouse Forebrain Generates Multiple Cognitive Impairments

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders

“…CACNA1A encodes Ca V 2.1 channel, which is the most dominant presynaptic calcium channel in central synapses, particularly those ones from Purkinje cells in the cerebellum and excitatory synapses of cortex and hippocampus. Although Ca V 2.1 KO mice are postnatally lethal [217,218,219], forebrain ablation of Ca V 2.1 channels results in deficits in spatial learning and memory, and increased exploratory behavior suggesting a potential role of this channel in psychiatric-related phenotypes [220]. Various mutations in CACNA1A, causing gain or loss of function, have been found in patients with hemiplegic migraine 1 (FHM-1), Episodic Ataxia 2 (EA-2), SCA-6, and epilepsy [10].…”