Correction

Xu, Zhiliang; Lioi, Joshua; Mu, Jian; Kamocka, Malgorzata M.; Liu, Xiaomin; Chen, Danny Z.; Rosen, Elliot D.; Alber, Mark

doi:10.1016/j.bpj.2010.09.009

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…platelet-surface interactions (Kent et al 2010), in particular as regards deposition and activation in blood stream. More in general, phenomena behind thrombus formation and growth are modeled by several approaches: Eulerian (Karsaj and Humphrey 2009), Lagrangian (Kamada et al 2010) and hybrid (Fogelson and Guy 2008;Xu et al 2010).…”

Section: Thrombi and Atherosclerotic Plaquesmentioning

confidence: 99%

Removing vascular obstructions: a challenge, yet an opportunity for interventional microdevices

Miloro

Sinibaldi

Menciassi

et al. 2012

Biomed Microdevices

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Cardiovascular diseases are the leading cause of death worldwide; they are mainly due to vascular obstructions which, in turn, are mainly caused by thrombi and atherosclerotic plaques. Although a variety of removal strategies has been developed for the considered obstructions, none of them is free from limitations and conclusive. The present paper analyzes the physical mechanisms underlying state-of-art removal strategies and classifies them into chemical, mechanical, laser and hybrid (namely chemo-mechanical and mechano-chemical) approaches, while also reviewing corresponding commercial/research tools/devices and procedures. Furthermore, challenges and opportunities for interventional micro/nanodevices are highlighted. In this spirit, the present review should support engineers, researchers active in the micro/nanotechnology field, as well as medical doctors in the development of innovative biomedical solutions for treating vascular obstructions. Data were collected by using the ISI Web of Knowledge portal, buyer's guides and FDA databases; devices not reported on scientific publications, as well as commercial devices no more for sale were discarded. Nearly 70% of the references were published since 2006, 55% since 2008; these percentages respectively raise to 85% and 65% as regards the section specifically reviewing state-of-art removal tools/devices and procedures.

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Section: Thrombi and Atherosclerotic Plaquesmentioning

confidence: 99%

Removing vascular obstructions: a challenge, yet an opportunity for interventional microdevices

Miloro

Sinibaldi

Menciassi

et al. 2012

Biomed Microdevices

View full text Add to dashboard Cite

show abstract

Multiscale Modeling of Platelet Adhesion and Thrombus Growth

Wang

King

2012

Ann Biomed Eng

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Our hemostatic system, when called to action, depends on the complex arrangement of a tightly regulated and extensive network of molecules with versatile functionality. Experimental methods have demonstrated marked improvement through enhanced condition-control and monitoring. However, this approach continues to provide limited explanations of the role of individual elements or of a specific component within the entire system. To fill this void, multiscale simulations based on high throughput computing and comprehensive mathematical models are showing their strength in not only revealing hidden physiological mechanisms but also predicting pharmacological/phenotypical outcome in hemostasis reactions based on quantitative analysis. In this review article, we present up-to-date computational methods that simulate the process of platelet adhesion and thrombus growth, compare and summarize their advantages and drawbacks, verify their predictive power, and project their future directions. We provide an in-depth summary of one such computational method-Platelet Adhesive Dynamics (PAD)-and discuss its application in simulating platelet aggregation and thrombus development.

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