2015
DOI: 10.18632/aging.100740
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Abstract: Vascular calcifications are frequent in chronic renal disease and are associated to significant cardiovascular morbidity and mortality. The long term predictive value of coronary artery calcifications detected by multi-layer spiral computed tomography for major cardiovascular events was evaluated in non-diabetic Caucasian patients on maintenance hemodialysis free of clinical cardiovascular disease. Two-hundred and five patients on maintenance hemodialysis were enrolled into this observational, prospective coho… Show more

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Cited by 31 publications
(51 citation statements)
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References 113 publications
(51 reference statements)
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“…There is a strong relationship between mortality and total coronary artery calcium score evaluated by cardiac computed tomography. The coronary artery calcium score has a well‐established correlation with coronary plaque burden, with higher score values being associated with increased risk of adverse cardiovascular outcomes . Nevertheless, coronary calcification, as we have also shown , can be considered as an indirect plaque vulnerability factor, because coronary artery calcium score does not predict the segment that will undergo rupture but identifies vulnerable patients at risk of fatal cardiac events.…”
Section: Ageing and Vascular Calcificationmentioning
confidence: 85%
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“…There is a strong relationship between mortality and total coronary artery calcium score evaluated by cardiac computed tomography. The coronary artery calcium score has a well‐established correlation with coronary plaque burden, with higher score values being associated with increased risk of adverse cardiovascular outcomes . Nevertheless, coronary calcification, as we have also shown , can be considered as an indirect plaque vulnerability factor, because coronary artery calcium score does not predict the segment that will undergo rupture but identifies vulnerable patients at risk of fatal cardiac events.…”
Section: Ageing and Vascular Calcificationmentioning
confidence: 85%
“…Modifications of microRNAs , signalling or autophagy correlated with ageing determine various structural and physiological changes of the arterial wall that predispose it to atherosclerosis. In particular, inversion of the elastin/collagen ratio and the nonenzymatic glycosylation of some proteins present in the arterial wall, such as collagen, capable of cross‐linking adjacent proteins increase the mechanical vessel rigidity and stiffness. The reduction in elasticity and distensibility of the arterial wall determine a reduction in compliance leading to increased systolic and decreased diastolic blood pressure.…”
Section: Age‐related Modifications Of the Arterial Wall And Atherosclmentioning
confidence: 99%
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“…Although the prevalence of VC is higher in patients with CKD, arteries in some sites are not sensitive to calcification compared to large arteries, such as finger arteries [11]. The speed, mechanism, pathophysiological manifestations, risk factors, and prognosis of different grades of arterial calcification may be different.…”
Section: Study On the Prevalence Of Vascular Calcification In Differementioning
confidence: 99%
“…Another potential effect of PTH would be the increase of renin release and activation of the renin-angiotensin system, a process mediated by serum calcium and renal 1-alpha hydroxylase [69]. Aman et al have underlined the effect of PTH as the major determining factor of coronary artery lesions, ranging from the discontinuity of the elastic lamina to the calcification of the medial layer, confirming the agreeable action of PTH [70].…”
Section: Role Of Parathyroid Hormonementioning
confidence: 96%