This registry describes our preliminary experience with a novel introducing‐catheter allowing direct percutaneous introduction of the 6F guiding catheter (G‐C), minimizing the puncture size, preventing vessel scraping, and improving the pushability and torque response of the G‐C. In 1995, 203 patients had sheathless PTCA, using this device. Eighty‐five percent were male. Mean age was 65 ± 10 years. Thirty‐nine percent had stable angina, 35% unstable angina, 7% evolving infarction, and 19% recent infarction. Two hundred fifty‐six lesions were treated (1.26/patient). One hundred eight patients (52%) received one (85%) or more than one (15%) stent. The procedural success rate was 98%. Mean coronary stenosis was 82 ± 10% and decreased to 20 ± 15% after PTCA. No major complication occurred. The guiding catheter was immediately removed in 95% of patients, despite heparinization. No patient required surgery or blood transfusion for vascular complications, and only 7 had minor local complications (3.5%). Sheathless angioplasty provides no technical difficulties and has the same safety and quality as conventional angioplasty using a sheath. Immediate removal of the guiding catheter, without keeping vascular access, has no deleterious effect, allows early mobilization, and may limit the risk of vascular complications. Cathet. Cardiovasc. Diagn. 43:331–335, 1998. © 1998 Wiley‐Liss, Inc.