Corneal Microstructural Changes in Nerve Fiber, Endothelial and Epithelial Density After Cataract Surgery in Patients With Diabetes Mellitus

Misra, Stuti; Goh, Yi Wei; Patel, Dipika V.; Riley, Andrew F; McGhee, Charles N J

doi:10.1097/ico.0000000000000320

Cited by 57 publications

(49 citation statements)

References 34 publications

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“…Diabetes has been shown in some studies to increase corneal endothelial cell loss with or without intraocular surgery, suggesting that diabetic hyperglycemia contributes to cell death, [7][8][9][10]19 while other studies have found no difference in endothelial cell density with or without intraocular surgery between diabetics and nondiabetics. 63 The same tension has been demonstrated surrounding keratoplasty, where some studies have shown a deleterious impact of diabetes on donor tissue 36 but not outcomes 33,64 using diabetic tissue, and other studies have shown negative impact 32,65 or no impact 33 on keratoplasty outcomes in diabetic recipients. Considering the increasing prevalence of this disease, 66 it is imperative to obtain greater clarity on the issue of diabetes and endothelial cell health.…”

Section: Discussionmentioning

confidence: 84%

Mitochondrial and Morphologic Alterations in Native Human Corneal Endothelial Cells Associated With Diabetes Mellitus

Aldrich

Schlötzer‐Schrehardt

Skeie

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Extracellular flux analysis suggests that corneal endothelial cells of donors with advanced diabetes have impaired mitochondrial function. Metabolic findings are supported by observed differences in mitochondrial morphology of advanced diabetic samples but not controls. Additional studies are needed to determine the precise mechanism(s) by which mitochondria become impaired in diabetic corneal endothelial cells.

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Section: Discussionmentioning

confidence: 84%

Mitochondrial and Morphologic Alterations in Native Human Corneal Endothelial Cells Associated With Diabetes Mellitus

Aldrich

Schlötzer‐Schrehardt

Skeie

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…105, 106, 107, 108, 109, 110, 111, 112 The biggest study of the 5, conducted in Vellor, India, involved 153 participants with DM and 163 age-matched controls, and was performed on patients before and after cataract surgery up to 3 months postoperatively. 112 Preoperative examinations showed no statistically significant difference between the groups in any of the corneal endothelial parameters.…”

Section: Cornea Endothelial Diseasementioning

confidence: 99%

A systematic review on the impact of diabetes mellitus on the ocular surface

2017

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Diabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment. In addition, alterations of immune cells in corneas suggest an inflammatory component in diabetic complications. Furthermore, impaired corneal epithelial wound healing may also imply more widespread disease. The non-invasiveness and improvement in imaging technology facilitates the emergence of new screening tools. Systemic control of diabetes can improve ocular surface health, possibly aided by anti-inflammatory and vasoprotective agents.

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“…One of the most common co morbidities among people with cataract is diabetes mellitus [7] , [8] , [9] . We know that increased blood sugar levels affect ocular cells in many ways [10] , [11] and in particular there are reports about the correlation of diabetes and corneal endothelial function [12] , [13] , [14] .…”

Section: Introductionmentioning

confidence: 99%

Corneal oedema after phacoemulsification in the early postoperative period: A qualitative comparative case-control study between diabetics and non-diabetics

Tsaousis

Panagiotou

Kostopoulou

et al. 2016

Annals of Medicine &Amp; Surgery

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BackgroundThe occurrence and severity of corneal oedema after phacoemulsification is dependent on the integrity of corneal endothelial cells. The function of these cells is affected by diabetes mellitus and consequently the behaviour of the cornea in diabetic patients is of special interest.AimTo compare the frequency of corneal oedema in two age-matched groups of diabetics and non diabetic patients that underwent cataract surgery in the Ophthalmology Department of Xanthi General Hospital in Greece.MethodsA retrospective case control study was conducted in a retrospective fashion. Patients in the control and study groups were assessed regarding the severity of corneal oedema at three postoperative visits: days 1, 3–7, 10–14 after the operation. Ultrasound energy consumed during phacoemulsification was also a parameter of interest and possible correlations with the pre-existent cataract severity and the subsequent incidence of corneal oedema were investigated.ResultsThe difference in the incidence of severe corneal oedema between the study and control group was statistically significant: (4.5% non diabetics vs 14.3% diabetics). The consumed ultrasound energy did not define final clinical outcome.ConclusionsThe existence of diabetes mellitus type 2 appears to be a significant risk factor for the development of persistent corneal oedema. The results of our study led to the modification of the algorithm for postoperative follow-up of patients of this remote area of Greece.

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Corneal Microstructural Changes in Nerve Fiber, Endothelial and Epithelial Density After Cataract Surgery in Patients With Diabetes Mellitus

Abstract: Subbasal nerve density is reduced after cataract surgery in patients with and without DM. However, lower initial SBN density in patients with DM may predispose them to develop diabetic keratopathy. DM does not predispose to greater endothelial loss following phacoemulsification.

Cited by 57 publications

References 34 publications

Mitochondrial and Morphologic Alterations in Native Human Corneal Endothelial Cells Associated With Diabetes Mellitus

Mitochondrial and Morphologic Alterations in Native Human Corneal Endothelial Cells Associated With Diabetes Mellitus

A systematic review on the impact of diabetes mellitus on the ocular surface

Corneal oedema after phacoemulsification in the early postoperative period: A qualitative comparative case-control study between diabetics and non-diabetics

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