Corneal Edema Due to Asclepias curassavica

Corneal Toxicity Secondary to Latex From Asclepias curassavica in a Pediatric Patient

“…Of the published case reports of milkweed corneal toxicity, the patient ages range from 37 to 74 years, and all patients experienced a significant improvement in symptoms within 3 days and showed resolution of corneal edema within 1 to 3 months. [2][3][4][5][6][7] Similarly, our patient showed resolution of epithelial defect and improvement in stromal edema 3 days after exposure to milkweed latex and complete resolution within 18 days. It is possible that our patient's young age and therefore robust corneal endothelial cells contributed to his rapid rate of recovery.…”

Corneal Toxicity Secondary to Latex From Asclepias curassavica in a Pediatric Patient

“…Of the published case reports of milkweed corneal toxicity, the patient ages range from 37 to 74 years, and all patients experienced a significant improvement in symptoms within 3 days and showed resolution of corneal edema within 1 to 3 months. [2][3][4][5][6][7] Similarly, our patient showed resolution of epithelial defect and improvement in stromal edema 3 days after exposure to milkweed latex and complete resolution within 18 days. It is possible that our patient's young age and therefore robust corneal endothelial cells contributed to his rapid rate of recovery.…”

Ocular Toxicity Secondary toAsclepias physocarpa: The Balloon Plant

“…The two similar published cases report an analogous clinical course with full recovery and without sequelae [1, 2]. However, despite being apparently a self-limited situation, the modification of the endothelial cells pattern in our patient's RE suggests the existence of a residual effect.…”

Corneal endothelial dysfunction caused by Asclepias curassavica in a young farmer

“…In this case, cardenolides from the leaf of the Asclepias plant induced corneal edema several hours after the contact to the eye, as in other case reports 1 , 3 . Cardenolides can penetrate the intact cornea without damage to the epithelium, 1 , 2 and cause corneal endothelial toxicity by inhibiting the endothelial Na + /K + -ATPase pump function 1 . Topical application of digoxin, a purified cardiac glycoside, also led to similar corneal endothelial dysfunction by inhibiting endothelial Na + /K + -ATPase, which was observed several hours after the application and completely resolved after withdrawal of the drug 5 .…”

“…In our patient, we used aggressive anti-inflammatory treatment including topical prednisolone acetate 1% and cyclosporine 0.1% as well as oral prednisolone. Although previous reports suggest that the corneal endothelial toxicity associated with cardenolides can resolve spontaneously, 1 , 2 and addition of topical steroid would be enough,1, 2, 3, 4 , 8 all the patients in the cases were elderly of 60 year or older. The young age of our patient could be associated with an increased risk of more aggressive inflammation and tissue destruction, while the patient was healthy enough to tolerate vigorous topical and systemic anti-inflammatory treatment.…”

Corneal Toxicity Secondary to Latex From Asclepias curassavica in a Pediatric Patient

“…Of the published case reports of milkweed corneal toxicity, the patient ages range from 37 to 74 years, and all patients experienced a significant improvement in symptoms within 3 days and showed resolution of corneal edema within 1 to 3 months. [2][3][4][5][6][7] Similarly, our patient showed resolution of epithelial defect and improvement in stromal edema 3 days after exposure to milkweed latex and complete resolution within 18 days. It is possible that our patient's young age and therefore robust corneal endothelial cells contributed to his rapid rate of recovery.…”

Ocular Toxicity Secondary toAsclepias physocarpa: The Balloon Plant

“…The two similar published cases report an analogous clinical course with full recovery and without sequelae [1, 2]. However, despite being apparently a self-limited situation, the modification of the endothelial cells pattern in our patient's RE suggests the existence of a residual effect.…”

Corneal endothelial dysfunction caused by Asclepias curassavica in a young farmer

“…In this case, cardenolides from the leaf of the Asclepias plant induced corneal edema several hours after the contact to the eye, as in other case reports 1 , 3 . Cardenolides can penetrate the intact cornea without damage to the epithelium, 1 , 2 and cause corneal endothelial toxicity by inhibiting the endothelial Na + /K + -ATPase pump function 1 . Topical application of digoxin, a purified cardiac glycoside, also led to similar corneal endothelial dysfunction by inhibiting endothelial Na + /K + -ATPase, which was observed several hours after the application and completely resolved after withdrawal of the drug 5 .…”

“…In our patient, we used aggressive anti-inflammatory treatment including topical prednisolone acetate 1% and cyclosporine 0.1% as well as oral prednisolone. Although previous reports suggest that the corneal endothelial toxicity associated with cardenolides can resolve spontaneously, 1 , 2 and addition of topical steroid would be enough,1, 2, 3, 4 , 8 all the patients in the cases were elderly of 60 year or older. The young age of our patient could be associated with an increased risk of more aggressive inflammation and tissue destruction, while the patient was healthy enough to tolerate vigorous topical and systemic anti-inflammatory treatment.…”

Corneal Toxicity Secondary to Latex From Asclepias curassavica in a Pediatric Patient

“…Of the published case reports of milkweed corneal toxicity, the patient ages range from 37 to 74 years, and all patients experienced a significant improvement in symptoms within 3 days and showed resolution of corneal edema within 1 to 3 months. [2][3][4][5][6][7] Similarly, our patient showed resolution of epithelial defect and improvement in stromal edema 3 days after exposure to milkweed latex and complete resolution within 18 days. It is possible that our patient's young age and therefore robust corneal endothelial cells contributed to his rapid rate of recovery.…”

Ocular Toxicity Secondary toAsclepias physocarpa: The Balloon Plant

“…The two similar published cases report an analogous clinical course with full recovery and without sequelae [1, 2]. However, despite being apparently a self-limited situation, the modification of the endothelial cells pattern in our patient's RE suggests the existence of a residual effect.…”

Corneal endothelial dysfunction caused by Asclepias curassavica in a young farmer

“…In this case, cardenolides from the leaf of the Asclepias plant induced corneal edema several hours after the contact to the eye, as in other case reports 1 , 3 . Cardenolides can penetrate the intact cornea without damage to the epithelium, 1 , 2 and cause corneal endothelial toxicity by inhibiting the endothelial Na + /K + -ATPase pump function 1 . Topical application of digoxin, a purified cardiac glycoside, also led to similar corneal endothelial dysfunction by inhibiting endothelial Na + /K + -ATPase, which was observed several hours after the application and completely resolved after withdrawal of the drug 5 .…”

“…In our patient, we used aggressive anti-inflammatory treatment including topical prednisolone acetate 1% and cyclosporine 0.1% as well as oral prednisolone. Although previous reports suggest that the corneal endothelial toxicity associated with cardenolides can resolve spontaneously, 1 , 2 and addition of topical steroid would be enough,1, 2, 3, 4 , 8 all the patients in the cases were elderly of 60 year or older. The young age of our patient could be associated with an increased risk of more aggressive inflammation and tissue destruction, while the patient was healthy enough to tolerate vigorous topical and systemic anti-inflammatory treatment.…”