Corneal Biopsy in Chronic Keratitis

Corneal biopsy in keratitis performed with the microtrephine

“…If preceded by antibiotic treatment, corneal smears often show negative results because drug concentrations at the site of infection are not always sufficient to kill infective organisms rapidly [3]. In these cases a corneal biopsy is a useful adjunct in the evaluation of pathogens [5,9,15]. For lack of sufficient and safe methods of obtaining corneal biopsies, severe keratitis is often followed by penetrating keratoplasty.…”

Corneal biopsy in keratitis performed with the microtrephine

“…If preceded by antibiotic treatment, corneal smears often show negative results because drug concentrations at the site of infection are not always sufficient to kill infective organisms rapidly [3]. In these cases a corneal biopsy is a useful adjunct in the evaluation of pathogens [5,9,15]. For lack of sufficient and safe methods of obtaining corneal biopsies, severe keratitis is often followed by penetrating keratoplasty.…”

Microbiopsy in healthy rabbit corneas. A long‐term study

“…On the other hand, it provides sufficient tissue for electron microscopy, histological and biochemical analysis. Inability to obtain a definitive diagnosis by corneal scraping may be related to the depth of some pathogens (Newton et al 1987;Ishibashi & Kaufman 1986). Friedländer (1988) formerly used a 3-5 mm trephine.…”

Bacterial Keratitis Preferred Practice Pattern®

“…92 Corneal biopsy may also be indicated if the infiltrate is located in the mid or deep stroma with overlying uninvolved tissue. 93,94 With a cooperative patient, corneal biopsy may be performed at the slit-lamp biomicroscope or operating microscope.…”

Corneal biopsy in keratitis performed with the microtrephine

“…If preceded by antibiotic treatment, corneal smears often show negative results because drug concentrations at the site of infection are not always sufficient to kill infective organisms rapidly [3]. In these cases a corneal biopsy is a useful adjunct in the evaluation of pathogens [5,9,15]. For lack of sufficient and safe methods of obtaining corneal biopsies, severe keratitis is often followed by penetrating keratoplasty.…”

Microbiopsy in healthy rabbit corneas. A long‐term study

“…On the other hand, it provides sufficient tissue for electron microscopy, histological and biochemical analysis. Inability to obtain a definitive diagnosis by corneal scraping may be related to the depth of some pathogens (Newton et al 1987;Ishibashi & Kaufman 1986). Friedländer (1988) formerly used a 3-5 mm trephine.…”

Bacterial Keratitis Preferred Practice Pattern®

“…92 Corneal biopsy may also be indicated if the infiltrate is located in the mid or deep stroma with overlying uninvolved tissue. 93,94 With a cooperative patient, corneal biopsy may be performed at the slit-lamp biomicroscope or operating microscope.…”

Corneal biopsy in keratitis performed with the microtrephine

“…If preceded by antibiotic treatment, corneal smears often show negative results because drug concentrations at the site of infection are not always sufficient to kill infective organisms rapidly [3]. In these cases a corneal biopsy is a useful adjunct in the evaluation of pathogens [5,9,15]. For lack of sufficient and safe methods of obtaining corneal biopsies, severe keratitis is often followed by penetrating keratoplasty.…”

Microbiopsy in healthy rabbit corneas. A long‐term study

“…On the other hand, it provides sufficient tissue for electron microscopy, histological and biochemical analysis. Inability to obtain a definitive diagnosis by corneal scraping may be related to the depth of some pathogens (Newton et al 1987;Ishibashi & Kaufman 1986). Friedländer (1988) formerly used a 3-5 mm trephine.…”

Bacterial Keratitis Preferred Practice Pattern®

“…92 Corneal biopsy may also be indicated if the infiltrate is located in the mid or deep stroma with overlying uninvolved tissue. 93,94 With a cooperative patient, corneal biopsy may be performed at the slit-lamp biomicroscope or operating microscope.…”