Corneal Autograft and Allograft in a 10-Month-Old Premature Boy With Acquired Bilateral Corneal Opacities

Tannen, Bradford; Zarbin, Marco A.; Bhagat, Neelakshi; Wagner, Rudolph S; Chu, David

doi:10.1097/ico.0b013e3182031a72

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…28 In cases of nonhealing infectious ulcerative keratitis, autograft transplant using the clearer cornea can be considered, and has proven to be successful, at the 3-year follow up. 15 Corneal autologous grafts are preferable to allografts, but autologous grafts can be difficult in cases of extensive bilateral keratitis, because clear donor cornea is required. 25 In the two patients who underwent laser photocoagulation and in the one who underwent PPV, the epithelial defect was not noted until several days after the procedure.…”

Section: Discussionmentioning

confidence: 99%

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Infectious Ulcerative Keratitis Following Retinopathy of Prematurity Treatment

Modi¹,

Chu²,

Wagner³

et al. 2015

J Pediatr Ophthalmol Strabismus

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Section: Discussionmentioning

confidence: 99%

“…After 10.5 months of follow-up, the patient's right eye underwent a successful allograft using the clearer left cornea as the donor (visual potential of the left eye was thought to be extremely poor) and transplanting the opaque right cornea to the left eye, and the graft remained clear at the 3-year follow-up. 15…”

Section: Patientmentioning

confidence: 99%

Infectious Ulcerative Keratitis Following Retinopathy of Prematurity Treatment

Modi¹,

Chu²,

Wagner³

et al. 2015

J Pediatr Ophthalmol Strabismus

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“…The overall mean time frame for follow up was 23 months (range 0.1 – 216 months) from 39 patients recorded (Table 1). 2, 4–22 Of those patients, 7 complications have been described including 1 patient with an immediate post operative complication (poor suture healing after surgery) 15 , and 6 patients with later complications from uveitis 8 , retrocorneal membrane growth, posterior epithelial downgrowth, infection after retinal surgery 15 , superficial punctate keratopathy 21 , and corneal scarring due to dry eye syndrome. 11 We herein report the first cases of late endothelial failure after autologous PKP surgery to make clinicians aware of this potential complication and highlight the need to better understand factors associated with ongoing endothelial cell loss after successful surgery.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Graft Failure After Contralateral Autologous Corneal Transplantation

Martínez¹,

Pérez²,

Karp³

et al. 2013

Cornea

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Purpose To report on outcomes after contralateral autologous penetrating keratoplasty (APK). Methods Design Case series. Patient population 5 patients who received a contralateral APK and a simultaneous allogeneic PKP in the donor eye at the Bascom Palmer Eye Institute and the Miami Veterans Affairs Hospital. Results The median patient age at the time of surgery in our 5 patients was 67 years (range, 58–88 years); 4 patients were male and 1 female, 1 patient was white and 4 black. The surgery was uneventful in all cases and no operative or immediate post-operative complications occurred in either eye. Follow-up time ranged from 18–54 months (mean, 35 months; median, 34 months). During this time, 4 of the autologous grafts failed due to endothelial attenuation. Identified risk factors for failure in the autologous eyes included the presence of a glaucoma tube (5/5), previous graft failure (4/5) and anterior synechiae in (2/5). Conclusion This study is the first to describe graft failure due to slow endothelial attenuation after APK. This study underscores the importance of non-immunologic factors in endothelial cell loss after corneal transplant surgery and highlights the need for further research to understand and modulate endothelial loss.

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“…penetrating keratoplasty on their only functional eye and have a clear cornea on their nonfunctional eye as the chances of graft rejection in such cases are theoretically eliminated [1][2][3]. However, because this procedure requires a clear cornea in the nonfunctional eye and scarred cornea in the eye with visual potential, the combination of which does not occur commonly, very few cases have been reported in the literature [1,3,4]. Here we describe a case where we were able to salvage vision by corneal autografting in a patient.…”

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confidence: 99%

Simultaneous Corneal Allograft and Contralateral Corneal Autograft: A Case Report

Sitaula¹,

Sanjay²

2019

Int J Ophthalmol Clin Res

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Introduction: Autologous contralateral autograft has been described as a useful procedure in patients who require penetrating keratoplasty on their only functional eye and have a clear cornea on their nonfunctional eye due to the low chances of graft rejection in autografts. Here we describe a case where we were able to salvage vision by corneal autografting in a blind patient. Case: A 65-year-old male had blurred vision in both eyes with visual acuity of perception of light (PL) in right eye (RE) and hand motion (HM) in left eye (LE). On examination, RE had a clear cornea, sluggish pupillary reaction with presence of Relative afferent pupillary defect and glaucomatous optic atrophy. Left eye had a corneal opacity following healed corneal ulcer. RE Penetrating Keratoplasty (PK) using an allograft and left eye PK using the contralateral autograft was done. Post-operatively, RE developed persistent epithelial defect and eventually failed after 2 months while the left autograft got fully epithelialized and remained clear till 2 years follow up even after steroids were stopped. Conclusion: Autokeratoplasty have higher chances of graft survival due to the absence of immune graft rejection and resultant postoperative endothelial cell loss. Hence, it may be considered first in any case where there is this unique combination of opaque cornea in an eye with better visual potential and a clear cornea in an eye without visual potential.

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Corneal Autograft and Allograft in a 10-Month-Old Premature Boy With Acquired Bilateral Corneal Opacities

Abstract: In circumstances in which a viable cornea is available from the patient's worse prognosis eye, a corneal autograft is a potential treatment option.

Cited by 6 publications

References 11 publications

Infectious Ulcerative Keratitis Following Retinopathy of Prematurity Treatment

Infectious Ulcerative Keratitis Following Retinopathy of Prematurity Treatment

Endothelial Graft Failure After Contralateral Autologous Corneal Transplantation

Simultaneous Corneal Allograft and Contralateral Corneal Autograft: A Case Report

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