Cornea Pseudoguttata

Clinical Characterization of Corneal Endotheliitis With Distinctive Features in Shiba Inu Dogs

“…In several cases, low-reflection areas were detected, which may represent corneal pseudoguttata-like changes. Pseudoguttata are dark, acellular spots transiently observed in the endothelium and have been reported to be associated with inflammatory diseases, indicating endothelial edema without Descemet's involvement [14,15]. Typically, corneal pseudoguttata appear as numerous dark holes of different sizes under specular microscopy [15,16].…”

Clinical Characterization of Corneal Endotheliitis With Distinctive Features in Shiba Inu Dogs

“…In several cases, low-reflection areas were detected, which may represent corneal pseudoguttata-like changes. Pseudoguttata are dark, acellular spots transiently observed in the endothelium and have been reported to be associated with inflammatory diseases, indicating endothelial edema without Descemet's involvement [14,15]. Typically, corneal pseudoguttata appear as numerous dark holes of different sizes under specular microscopy [15,16].…”

Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy

“…Indeed, we saw two Exp + specimens with no guttae. Though misdiagnosis of these individuals cannot be ruled out, a possible explanation is that clinical guttae can result from the distortion of light going through the irregularly shaped collagen bundles of the DM and not by the guttae themselves (Magovern et al., 1979; Gottsch, Sundin, et al., 2005; Gottsch, Zhang, et al., 2005), or due to pseudoguttae from oedema (Doughty et al., 2011; Krachmer et al., 1981), which would not be observed histopathologically. The histopathological differences may also be influenced by exogenous or environmental factors, like oxidative stress and ultraviolet light (Jurkunas et al., 2010; Ong Tone et al., 2021), as well as surgery‐related factors.…”

Radial keratotomy associated endothelial degeneration

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Clinical Characterization of Corneal Endotheliitis With Distinctive Features in Shiba Inu Dogs

“…In several cases, low-reflection areas were detected, which may represent corneal pseudoguttata-like changes. Pseudoguttata are dark, acellular spots transiently observed in the endothelium and have been reported to be associated with inflammatory diseases, indicating endothelial edema without Descemet's involvement [14,15]. Typically, corneal pseudoguttata appear as numerous dark holes of different sizes under specular microscopy [15,16].…”

Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy

“…Indeed, we saw two Exp + specimens with no guttae. Though misdiagnosis of these individuals cannot be ruled out, a possible explanation is that clinical guttae can result from the distortion of light going through the irregularly shaped collagen bundles of the DM and not by the guttae themselves (Magovern et al., 1979; Gottsch, Sundin, et al., 2005; Gottsch, Zhang, et al., 2005), or due to pseudoguttae from oedema (Doughty et al., 2011; Krachmer et al., 1981), which would not be observed histopathologically. The histopathological differences may also be influenced by exogenous or environmental factors, like oxidative stress and ultraviolet light (Jurkunas et al., 2010; Ong Tone et al., 2021), as well as surgery‐related factors.…”

Radial keratotomy associated endothelial degeneration

“……”

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Clinical Characterization of Corneal Endotheliitis With Distinctive Features in Shiba Inu Dogs

“…In several cases, low-reflection areas were detected, which may represent corneal pseudoguttata-like changes. Pseudoguttata are dark, acellular spots transiently observed in the endothelium and have been reported to be associated with inflammatory diseases, indicating endothelial edema without Descemet's involvement [14,15]. Typically, corneal pseudoguttata appear as numerous dark holes of different sizes under specular microscopy [15,16].…”

Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy

“…Indeed, we saw two Exp + specimens with no guttae. Though misdiagnosis of these individuals cannot be ruled out, a possible explanation is that clinical guttae can result from the distortion of light going through the irregularly shaped collagen bundles of the DM and not by the guttae themselves (Magovern et al., 1979; Gottsch, Sundin, et al., 2005; Gottsch, Zhang, et al., 2005), or due to pseudoguttae from oedema (Doughty et al., 2011; Krachmer et al., 1981), which would not be observed histopathologically. The histopathological differences may also be influenced by exogenous or environmental factors, like oxidative stress and ultraviolet light (Jurkunas et al., 2010; Ong Tone et al., 2021), as well as surgery‐related factors.…”

Radial keratotomy associated endothelial degeneration

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