Core-shell functional nanospheres for oligonucleotide delivery. III. Stealth nanospheres

Abstract

Polymethyl methacrylate‐based stealth and functional nanospheres, specifically designed for the reversible adsorption of oligonucleotides (ODN), were prepared by emulsion polymerization of methyl methacrylate in the presence of an ionic comonomer, namely a quaternary ammonium salt of 2‐(dimethylamino)ethyl methacrylate, and a nonionic comonomer, namely a poly(ethylene glycol) methacrylate. The nanosphere size is substantially affected by the amount of both the nonionic and ionic comonomers. By appropriately adjusting the concentrations of the ionic and nonionic comonomers, the quaternary ammonium group and PEG chain surface densities can be finely tuned. Accordingly, a great variety of core‐shell‐type nanospheres, able to bind ODN and to induce dysopsonic effect, can be obtained. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 3347–3354, 2000

Preparation and retention of poly(ethylene oxide)‐grafted cationic polyacrylamide microparticles

“…This was due to the increasing system hydrophile‐lipophile balance (HLB) value when the DAC content in the monomer feed increased; this resulted in decreasing microemulsion stability, which produced particle interagglutination. Sparnacci et al16 also found this phenomenon while preparing polyacrylamide microparticles. We suppose that a high cationic monomer concentration could prolong the particle coring period and widen the particle distribution.…”

Preparation and retention of poly(ethylene oxide)‐grafted cationic polyacrylamide microparticles

“…This was due to the increasing system hydrophile‐lipophile balance (HLB) value when the DAC content in the monomer feed increased; this resulted in decreasing microemulsion stability, which produced particle interagglutination. Sparnacci et al16 also found this phenomenon while preparing polyacrylamide microparticles. We suppose that a high cationic monomer concentration could prolong the particle coring period and widen the particle distribution.…”

RAFT mediated polymerisation in heterogeneous media

“…Structuring these materials via core-shell techniques, i.e., multiple layers of polymer being added discretely to the particles to form complex polymer beads has become critical for many applications such as impact modifiers, 41 adhesives, coatings, biomedical applications, etc.…”

Green Synthesis of Hollow Structures through the Decomposition of Azo Compounds Incorporated inside Polystyrene Particles

“…Polymer particles are widely used in not only the materials field − but also the information and medical fields . Hollow polymer particles, which have a higher specific surface area and better insulative properties than their solid counterparts, are typically synthesized using a template. , However, template removal necessitates using chemical agents, such as hydrofluoric acid, − which entails a high environmental load.…”

Preparation and retention of poly(ethylene oxide)‐grafted cationic polyacrylamide microparticles

“…This was due to the increasing system hydrophile‐lipophile balance (HLB) value when the DAC content in the monomer feed increased; this resulted in decreasing microemulsion stability, which produced particle interagglutination. Sparnacci et al16 also found this phenomenon while preparing polyacrylamide microparticles. We suppose that a high cationic monomer concentration could prolong the particle coring period and widen the particle distribution.…”

RAFT mediated polymerisation in heterogeneous media

“…Structuring these materials via core-shell techniques, i.e., multiple layers of polymer being added discretely to the particles to form complex polymer beads has become critical for many applications such as impact modifiers, 41 adhesives, coatings, biomedical applications, etc.…”

Green Synthesis of Hollow Structures through the Decomposition of Azo Compounds Incorporated inside Polystyrene Particles

“…Polymer particles are widely used in not only the materials field − but also the information and medical fields . Hollow polymer particles, which have a higher specific surface area and better insulative properties than their solid counterparts, are typically synthesized using a template. , However, template removal necessitates using chemical agents, such as hydrofluoric acid, − which entails a high environmental load.…”

Preparation and retention of poly(ethylene oxide)‐grafted cationic polyacrylamide microparticles

“…This was due to the increasing system hydrophile‐lipophile balance (HLB) value when the DAC content in the monomer feed increased; this resulted in decreasing microemulsion stability, which produced particle interagglutination. Sparnacci et al16 also found this phenomenon while preparing polyacrylamide microparticles. We suppose that a high cationic monomer concentration could prolong the particle coring period and widen the particle distribution.…”

RAFT mediated polymerisation in heterogeneous media

“…Structuring these materials via core-shell techniques, i.e., multiple layers of polymer being added discretely to the particles to form complex polymer beads has become critical for many applications such as impact modifiers, 41 adhesives, coatings, biomedical applications, etc.…”

Green Synthesis of Hollow Structures through the Decomposition of Azo Compounds Incorporated inside Polystyrene Particles

“…Polymer particles are widely used in not only the materials field − but also the information and medical fields . Hollow polymer particles, which have a higher specific surface area and better insulative properties than their solid counterparts, are typically synthesized using a template. , However, template removal necessitates using chemical agents, such as hydrofluoric acid, − which entails a high environmental load.…”