Core Body Temperature but Not Intraabdominal Pressure Predicts Postoperative Complications Following Closed-System Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Administration

Goldenshluger, Michael; Zippel, Douglas; Ben‐Yaacov, Almog; Dux, Joseph; Yalon, Tal; Zendel, Alex; Rayman, Shlomi; Mor, Eyal; Berkenstadt, Haim; Fogel-Grinvald, Haya; Ventorrero, M.; Nissan, Aviram

doi:10.1245/s10434-017-6279-3

Cited by 22 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The method of manipulating IAP during HIPEC may partially attainable by controlling abdominal wall muscle relaxation or increasing perfusate volume. A retrospective 2018 study by Goldenshluger et al of 115 patients undergoing CRS-HIPEC supported that postoperative complications are not more frequent with increased IAP (41). However, in multivariate analysis, elevated mean CBT was a positive predictor.…”

Section: Surgical Approachesmentioning

confidence: 97%

Peritoneal mesothelioma

Greenbaum¹,

Alexander²

2020

Transl Lung Cancer Res

View full text Add to dashboard Cite

Malignant peritoneal mesothelioma (MPM) is a rare and lethal disease of the peritoneal lining, with high variability in biologic aggressiveness. Morbidity and mortality of the disease are related to progressive locoregional effects within the abdominal cavity, such as distention, pain, early satiety, and decreased oral intake that can ultimately lead to bowel obstruction and cachexia. The standard of care for patients with resectable disease remains cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), with potential survival outcomes greater than 5 years in appropriately selected patients. Patients with inoperable MPM can be offered systemic treatment, although the disease is usually refractory to standard chemotherapic regimens. Patients with MPM should be treated at high volume centers with strong consideration for inclusion in tumor registries and clinical trials. In 2020, research will continue to explore promising genetic and immunologic targets and focus on refinement of surgical methods to optimize CRS-HIPEC approaches.

show abstract

Section: Surgical Approachesmentioning

confidence: 97%

Peritoneal mesothelioma

Greenbaum¹,

Alexander²

2020

Transl Lung Cancer Res

View full text Add to dashboard Cite

show abstract

“…The closed technique greatly limits the risk of exposure to the chemotherapy agent by the operating room staff, though it sacrifices visibility of the abdominal cavity in the process, potentially allowing for pooling of heat and chemotherapy. Another major advantage of the closed technique is the ability to rapidly achieve and maintain hyperthermia as there is minimal heat loss and the elevated intraabdominal pressure associated with the closed technique may improve tissue penetration[ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

Leiting

Cloyd

Ahmed

et al. 2020

WJGO

View full text Add to dashboard Cite

BACKGROUND Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis can be performed in two ways: Open or closed abdominal technique. AIM To evaluate the impact of HIPEC method on post-operative and long-term survival outcomes. METHODS Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative database. Post-operative, recurrence, and overall survival outcomes were compared between those who received open vs closed HIPEC. RESULTS Of the 1812 patients undergoing curative-intent CRS and HIPEC, 372 (21%) patients underwent open HIPEC and 1440 (79%) underwent closed HIPEC. There was no difference in re-operation or severe complications between the two groups. Closed HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d mortalities. On multi-variable analysis, closed HIPEC technique was not a significant predictor for overall survival (hazards ratio: 0.75, 95% confidence interval: 0.51-1.10, P = 0.14) or recurrence-free survival (hazards ratio: 1.39, 95% confidence interval: 1.00-1.93, P = 0.05) in the entire cohort. These findings remained consistent in the appendiceal and the colorectal subgroups. CONCLUSION In this multi-institutional analysis, the HIPEC method was not independently associated with relevant post-operative or long-term outcomes. HIPEC technique may be left to the discretion of the operating surgeon.

show abstract

“…e tolerance of critically ill patients to EN is not only affected by the EN regimen but also by gastrointestinal function and intra-abdominal pressure. e gastrointestinal tract of critically ill patients is an integral part of the body's organs; it is inevitably affected by different degrees of ischemia, hypoxia or perfusion injury, and systemic reactions [13]. Increased capillary permeability of intestinal mucosa will lead to intestinal wall edema and intestinal dysfunction.…”

Section: Resultsmentioning

confidence: 99%

Application Effect of Intra‐Abdominal Pressure Monitoring System in Early Enteral Nutrition Nursing of ICU Patients

Song

Zhao

2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

In order to study and explore the application effect of intra-abdominal pressure monitoring in guiding ICU patients to implement early enteral nutrition therapy, we selected patients admitted to the emergency department of a hospital and classified them into groups A (n = 105) and B (n = 98). Among them, the A group gave early enteral nutrition treatment by monitoring the residual gastric mass, and the B group gave early enteral nutrition treatment by monitoring the stomach. It has been established that, compared to gastric residue monitoring, intra-abdominal pressure monitoring in ICU patients with early enteral nutrition therapy has an obvious advantage, it helps to improve the prognosis of patients, and intra-abdominal pressure combined with gastric residual monitoring scheme can effectively reduce the early enteral nutrition in the ICU patients, the incidence of abdominal distension, vomiting, and make it reach the goal as soon as possible. Early enteral nutrition in patients with increased tolerance is of great significance.

show abstract

Core Body Temperature but Not Intraabdominal Pressure Predicts Postoperative Complications Following Closed-System Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Administration

Abstract: IAP level during closed-abdomen technique HIPEC is not associated with postoperative complications. However, elevated CBT may increase postoperative complications.

Cited by 22 publications

References 24 publications

Peritoneal mesothelioma

Peritoneal mesothelioma

Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

Application Effect of Intra‐Abdominal Pressure Monitoring System in Early Enteral Nutrition Nursing of ICU Patients

Contact Info

Product

Resources

About