Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates

Minatoya, Machiko; Sasaki, Seiko; Araki, Atsuko; Miyashita, Chihiro; Itoh, Shinji; Yamamoto, Jun; Matsumura, Tomohiro; Mitsui, Takahiko; Moriya, Kyoji; Cho, Kazutoshi; Morioka, Keita; Minakami, Hisanori; Shinohara, Nobuo; Kishi, Reiko

doi:10.1097/ede.0000000000000716

Cited by 48 publications

(28 citation statements)

References 37 publications

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“…The Sapporo Cohort of the Hokkaido Study on Environment and Children's Health allowed another group to examine simultaneous measurement of cord blood BPA, sex steroids and other hormones at the time of delivery. This did not find associations between BPA concentrations and levels of estradiol, progesterone or testosterone (though did note a weakly positive association with prolactin) in infant girls (Minatoya et al 2017). Yet, given the relatively rapid metabolism of BPA, cord blood measurements may be a limited mechanism of assessing exposure, possibly reflected in the reports that only 83.2% of samples had detectable BPA levels.…”

Section: Human Studiesmentioning

confidence: 77%

Do Prenatal Exposures Pose a Real Threat to Ovarian Function? BPA as a Case Study

Mathew

Mahalingaiah

2019

Reproduction

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Fetal development represents a time of potential vulnerability due to rapid cell division, organ development and limited fetal kidney/liver activity for detoxification and metabolism of exposures. Health effects of prenatal toxicant exposure have previously been described, but there is little cohesive evidence surrounding effects on ovarian function. Using bisphenol A (BPA) as a case study, we seek to examine whether a prominent prenatal environmental exposure can pose a real threat to human ovarian function. To do so, we broadly review human oogenesis and menstrual cycle biology. We then present available literature addressing prenatal bisphenol A and diverse outcomes at the level of the ovary. We highlight relevant human cohorts and mammalian models to review the existing data on prenatal exposures and ovarian disruption. Doing so suggests that while current exposures to BPA have not shown marked or consistent results, there is data sufficient to raise concerns regarding ovarian function. Challenges in the examination of this question suggest the need for additional models and pathways by which to expand these examinations in humans.

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Section: Human Studiesmentioning

confidence: 77%

Do Prenatal Exposures Pose a Real Threat to Ovarian Function? BPA as a Case Study

Mathew

Mahalingaiah

2019

Reproduction

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“…In human epidemiology, studies have reported changes in TH parameters as a function of BPA exposure in adults ( 56 , 57 , 58 , 59 ), including in pregnant women ( 60 , 61 , 62 ). In pregnant women, maternal BPA levels were inversely ( 62 ) or positively ( 60 ) associated with T 4 levels while two studies reported no association ( 61 , 63 ). In humans, inverse associations of BPA with TSH have also been reported in both sexes ( 60 ) and in other cases, only in women ( 61 ).…”

Section: Phenolsmentioning

confidence: 94%

Thyroid-disrupting chemicals and brain development: an update

Mughal

Fini

Demeneix

2018

Endocrine Connections

131

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This review covers recent findings on the main categories of thyroid hormone–disrupting chemicals and their effects on brain development. We draw mostly on epidemiological and experimental data published in the last decade. For each chemical class considered, we deal with not only the thyroid hormone–disrupting effects but also briefly mention the main mechanisms by which the same chemicals could modify estrogen and/or androgen signalling, thereby exacerbating adverse effects on endocrine-dependent developmental programmes. Further, we emphasize recent data showing how maternal thyroid hormone signalling during early pregnancy affects not only offspring IQ, but also neurodevelopmental disease risk. These recent findings add to established knowledge on the crucial importance of iodine and thyroid hormone for optimal brain development. We propose that prenatal exposure to mixtures of thyroid hormone–disrupting chemicals provides a plausible biological mechanism contributing to current increases in the incidence of neurodevelopmental disease and IQ loss.

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“…Studies carried out in the general population and in mother/child cohorts showed positive [139][140][141], negative [142][143][144][145], and no associations between BPA exposure and serum T4 levels [143,[146][147][148][149][150][151], whereas the relationship with serum T3 levels was estimated in few studies, with different findings [139,141,142,149,150].…”

Section: Effects On Serum Th Levelsmentioning

confidence: 95%

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

Gorini

Bustaffa

Coi

et al. 2020

IJERPH

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Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors (EDCs), capable of interfering with estrogen and androgen activities, as well as being suspected of other health outcomes. Given the crucial role of thyroid hormones and the increasing incidence of thyroid carcinoma in the last few decades, this review analyzes the effects of BPS on the thyroid, considering original research in vitro, in vivo, and in humans published from January 2000 to October 2019. Both in vitro and in vivo studies reported the ability of BPs to disrupt thyroid function through multiple mechanisms. The antagonism with thyroid receptors (TRs), which affects TR-mediated transcriptional activity, the direct action of BPs on gene expression at the thyroid and the pituitary level, the competitive binding with thyroid transport proteins, and the induction of toxicity in several cell lines are likely the main mechanisms leading to thyroid dysfunction. In humans, results are more contradictory, though some evidence suggests the potential of BPs in increasing the risk of thyroid nodules. A standardized methodology in toxicological studies and prospective epidemiological studies with individual exposure assessments are warranted to evaluate the pathophysiology resulting in the damage and to establish the temporal relationship between markers of exposure and long-term effects.

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Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates

Abstract: Our findings suggested that fetal BPA levels might be associated with changes in certain reproductive hormone levels of neonates in a sex-specific manner, though further investigations are necessary.

Cited by 48 publications

References 37 publications

Do Prenatal Exposures Pose a Real Threat to Ovarian Function? BPA as a Case Study

Do Prenatal Exposures Pose a Real Threat to Ovarian Function? BPA as a Case Study

Thyroid-disrupting chemicals and brain development: an update

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

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