Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom <i>Hericium coralloides</i>

Wittstein, Kathrin; Rascher, Monique; Rupcic, Zeljka; Löwen, Eduard; Winter, Barbara; Köster, Reinhard W.; Stadler, Marc

doi:10.1021/acs.jnatprod.6b00371

Cited by 66 publications

(59 citation statements)

References 31 publications

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“…This indicates that they have the ability to replace the initial requirement for serum trophic factors in neuronal cultures. Consistent with our present study, corallocin A (C3) was shown to induce NGF and BDNF expression in astrocytes (Wittstein et al 2016). Several compounds from H. erinaceum have been suggested to improve brain function via NGF-related activity.…”

Section: Discussionsupporting

confidence: 91%

“…C2 and C4 were obtained from A2D by recrystallization followed by semi-preparative HPLC eluting with MeCN. The structures of isolated compounds were identified as N-de phenylethyl isohericerin (C1), hericene A (C2), corallocin A (C3) and 4-[3′,7′′-dimethyl-2′,6′-octadienyl]-2-formyl-3-hydroxy-5-methyoxybenzylalcohol (C4) by the analysis of the spectroscopic data and comparison with literature values (Li et al 2015;Wittstein et al 2016).…”

Section: Preparation Of Samplesmentioning

confidence: 99%

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Hericerin derivatives fromHericium erinaceusexert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory

Martínez-Mármol

Chai

Khan

et al. 2020

Preprint

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The traditional medicinal mushroom Hericium erinaceus has long been known for enhancing the peripheral nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity. It was also reported to protect against ageing-dependent cognitive decline in wildtype and in Alzheimer’s disease mouse models suggesting a yet to be defined action on neurons of the central nervous system. Here, we purified and identified biologically active compounds from H. erinaceus, based on their ability to promote neurite outgrowth in hippocampal neurons. N-de phenylethyl isohericerin (NDPIH), an isoindoline compound from this mushroom together with its hydrophobic derivative hericene A, were highly potent in inducing extensive axon outgrowth and neurite branching in the absence of serum demonstrating high neurotropic activity. NDPIH also induced enlarged growth cones suggestive of a brain-derived neurotrophic factor (BDNF)-like activity. Pharmacological inhibition of tropomyosin receptor kinase B (TrkB) by ANA12 prevented NDPIH-induced neurotrophic activity providing evidence that NDPIH acts via TrkB receptors to mediate its neurotrophic effect in central neurons. Finally, in vivo treatment with H. erinaceus crude extract and hericene A significantly increased BDNF and downstream pathway and enhanced learning and memory in the novel object recognition memory test. Our results suggest that hericene A can promote BDNF-like activity in neurons in vitro and in vivo thereby enhancing recognition memory.

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Section: Discussionsupporting

confidence: 91%

Section: Preparation Of Samplesmentioning

confidence: 99%

Hericerin derivatives fromHericium erinaceusexert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory

Martínez-Mármol

Chai

Khan

et al. 2020

Preprint

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“…Hericenones C-E from H. Erinaceus markedly potentiated the neurite outgrowth of PC12 cells in the presence of NGF (5 ng/mL) [ 32 ]. Treatment of PC12 cells with corallocins A- or C-conditioned media produced by 1321N1 astrocytes resulted in significant increase of neurite outgrowth [ 33 ]. Furthermore, it was demonstrated that increasing neurite outgrowth activity in PC12 cells by the above compounds exhibited a strong correlation with the stimulation of NGF synthesis [ 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway

Zhang

Cao

Kubo

et al. 2017

IJMS

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Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to improve memory. In this work, we investigated the neuroprotective and neuritogenic effects of the secondary metabolites isolated from the MeOH extract of cultured mycelium of H. erinaceus and the primary mechanisms involved. One new dihydropyridine compound (6) and one new natural product (2) together with five known compounds (1,3–5,7) were obtained and their structures were elucidated by spectroscopic analysis, including 2D NMR and HRMS. The cell-based screening for bioactivity showed that 4-chloro-3,5-dimethoxybenzoic methyl ester (1) and a cyathane diterpenoid, erincine A (3), not only potentiated NGF-induced neurite outgrowth but also protected neuronally-differentiated cells against deprivation of NGF in PC12 pheochromocytoma cells. Additionally, compound 3 induced neuritogenesis in primary rat cortex neurons. Furthermore, our results revealed that TrkA-mediated and Erk1/2-dependant pathways could be involved in 1 and 3-promoted NGF-induced neurite outgrowth in PC12 cells.

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“…For example, Hericium coralloides is a white fleshy and coral-like fungus growing mostly on dead or rotting hardwood (McCracken and Dodd, 1971). The fruiting bodies of H. coralloides are edible and considered as a delicious mushroom, and it has long been used in traditional Chinese medicine (TCM) to treat diseases (Wittstein et al 2016). In this study, we present the complete mitochondrial genome of Hericium coralloides (GenBank accession no: KY007042, NCBI Reference Sequence: NC_033903.1).…”

Section: Mitogenome Announcementmentioning

confidence: 99%

The complete mitochondrial genome of Hericium coralloides (Hericiaceae, Basidiomycota)

Zhang¹,

Li²,

Ye³

et al. 2017

Mitochondrial DNA Part B

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In this study, the complete mitochondrial genome of the medicinal mushroom Hericium coralloides (Hericiaceae, Basidiomycota) was sequenced. This mitochondrial genome is 72,961 bp in length and consisted of 14 protein-coding genes, 21 hypothetical open reading frames, 2 ribosomal RNA subunits and 27 transfer RNAs. The overall nucleotide composition of is 41.33% A, 40.71% T, 9.06% C and 8.90% G, with GC content of 17.96%. A phylogenetic tree with the complete mitochondrial genome sequences of Hericium coralloides together with 9 other affinis mushrooms was constructed. The newly achieved mitochondrial genome sequence seem to be useful for addressing taxonomic issues and studying related evolution events, which would contribute to enrich the fungal mitochondrial genome resource and promote the biological research.

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Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides

Cited by 66 publications

References 31 publications

Hericerin derivatives fromHericium erinaceusexert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory

Hericerin derivatives fromHericium erinaceusexert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory

Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway

The complete mitochondrial genome of Hericium coralloides (Hericiaceae, Basidiomycota)

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