CoQ<sub>10</sub> Function and Role in Heart Failure and Ischemic Heart Disease

Ayer, Anita; Macdonald, Peter S.; Stocker, Roland

doi:10.1146/annurev-nutr-071714-034258

Cited by 60 publications

(56 citation statements)

References 174 publications

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“…CoQ 10 has attracted great interest in the clinical studies for myocardial function and heart failure (158, 159). CoQ 10 effectively counteracts oxidative damage in IMM and improves mitochondrial efficiency, making myocardium more tolerated to hypoxia/reoxygenation stress (160, 161).…”

Section: Mitochondrial Targets For Cardiovascular Diseases (Cvd)mentioning

confidence: 99%

Nanotechnology inspired tools for mitochondrial dysfunction related diseases

Wen

Banik

Pathak

et al. 2016

Advanced Drug Delivery Reviews

111

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Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called “mitochondrial dysfunction related diseases”. One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers towards internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.

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Section: Mitochondrial Targets For Cardiovascular Diseases (Cvd)mentioning

confidence: 99%

Nanotechnology inspired tools for mitochondrial dysfunction related diseases

Wen

Banik

Pathak

et al. 2016

Advanced Drug Delivery Reviews

111

View full text Add to dashboard Cite

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“…CoQ10 is known as a radical scavenger and antioxidant that is effective on recovery of cardiac function and also relieving fatigue [25]. There is one report on the muscle protection effect by CoQ10 supplementation on exhaustive exercise-induced muscular injury of rats by the evaluation of the concentration changes of enzyme biomarkers, creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) in plasma [26,27].…”

Section: Study On Protection Of Muscle Cells By the Evaluation Of Cpkmentioning

confidence: 99%

Coenzyme Q10 - gamma cyclodextrin complex is a powerful nutraceutical for anti-aging and health improvements

Uekaji¹,

Terao²

2017

Biomed Res Clin Prac

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Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like, benzoquinone compound that functions primarily as an antioxidant, as a membrane stabilizer and as a cofactor in the production of adenosine triphosphate (ATP) by oxidative phosphorylation. The solubility of CoQ10 in water is extremely low, resulting in a low bioavailability by oral administration. Therefore, we attempted to improve the low dissolution and bioavailability of CoQ10 by means of complexation with various cyclodextrins (CDs). We found that the bioavailability of CoQ10 could be significantly enhanced by complexation with CDs, especially by the use of γCD. The CoQ10 -γCD complex reveals excellent pharmacokinetic properties not only significantly higher area under the CoQ10 concentration curve (AUC) in blood plasma from time 0-48 hr and higher maximum plasma concentration (C max ), but also the mean plasma levels even after 24 and 48 hours tended to be significantly higher after CoQ10 -γCD complex administration to healthy adult volunteers when compared with CoQ10 formulated in microcrystalline cellulose and administrated in the same way as the complex. We found that this long-lasting high CoQ10 concentration in plasma provides various health benefits. The proven benefits are: 1) Curative effects on damaged human skins by aging, UV and other pollutants in the air, 2) Anti-oxidant activity (study on the reduction of 8-hydroxy-2-deoxy guanosine (8-OHdG) in urine), 3) Protection of muscle cells (study on the reduction of myogenic enzymes, creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH)).

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“…The pooled effect size was robust and remained significant in the leave-one-out sensitivity analysis. Subgroup analysis suggested that the impact of statins on plasma CoQ10 concentrations is significant for all 4 …”

Section: Introductionmentioning

confidence: 98%

“…CoQ10 has several important roles in the human body such as: involvement in the biosynthesis of pyrimidine and beta-oxidation of fatty acids [2], modulation of the mitochondrial permeability transition pore [3], acting like a coenzyme for several important enzymatic steps in mitochondrial energy production, inhibition of the oxidation of proteins and DNA [4], stabilizing the membrane and preventing lipid peroxidation [5,6] and modulation the expression of genes [7], or recycling of radical forms of vitamin C and E [8].…”

Section: Introductionmentioning

confidence: 99%