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Cited by 5 publications
(5 citation statements)
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References 7 publications
(25 reference statements)
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“…It has been previously reported that complexation with Cu­(II) potentiates the antiproliferative activity of monothiosemicarbazones and bis­(thiosemicarbazones) and cellular copper is well-known to act as a potent oxidant, resulting in cellular ROS generation. , Thus, we assessed whether the antiproliferative activity of the selected bis­(thiosemicarbazones) that demonstrated either maintained or potentiated activity after copper­(II) complexation was related to oxidative stress generation.…”
Section: Resultsmentioning
confidence: 99%
“…It has been previously reported that complexation with Cu­(II) potentiates the antiproliferative activity of monothiosemicarbazones and bis­(thiosemicarbazones) and cellular copper is well-known to act as a potent oxidant, resulting in cellular ROS generation. , Thus, we assessed whether the antiproliferative activity of the selected bis­(thiosemicarbazones) that demonstrated either maintained or potentiated activity after copper­(II) complexation was related to oxidative stress generation.…”
Section: Resultsmentioning
confidence: 99%
“…7,9 Considering the increase in uptake of copper by malignant cells and its contribution to cancer progression, cellular copper is emerging as a potential target for developing new anti-cancer therapeutics. 12 Moreover, these agents overcome P-glycoprotein (P-gp)mediated drug resistance due to their ability to exploit P-gp activity in lysosomes, allowing the accumulation of these compounds in this target organelle. 10 Interestingly, the unique lysosomotropic ("lysosome loving") property of these ligands and their ability to form redox-active copper complexes in the lysosome allow these agents to induce cytotoxic activity in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…1,2,10,11 Indeed, a novel class of metal-binding anti-cancer agents, namely the di-2-pyridylketone thiosemicarbazone (DpT) series, form copper complexes inside the lysosomes of cancer cells, mediating their potent antitumour activity. 11,12 In this review, the mechanisms underlying copper metabolism and regulation in physiological systems and cells will be examined. 12 Moreover, these agents overcome P-glycoprotein (P-gp)mediated drug resistance due to their ability to exploit P-gp activity in lysosomes, allowing the accumulation of these compounds in this target organelle.…”
Section: Introductionmentioning
confidence: 99%
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