Copper Modifies the Activity of Sodium-Transporting Systems in Erythrocyte Membrane in Patients with Essential Hypertension

Kędzierska, Karolina; Bober, Joanna; Ciechanowski, Kazimierz; Gołembiewska, Edyta; Kwiatkowska, Ewa; Noceń, Iwona; Dołęgowska, Barbara; Dutkiewicz, Grażyna; Chlubek, Dariusz

doi:10.1385/bter:107:1:021

Cited by 12 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in erythrocyte SOD activity may be explained by differences in the concentrations of copper (Cu) and zinc (Zn), which are components of this enzyme. Both elements play a role in the development of arterial hypertension [37,38]. Deficiency of those metals may disturb the function of SOD and other enzymes, particularly in those that take part in the transport of electrolytes, e.g., the sodium-potassium ATP-ase in erythrocytes [38].…”

Section: Discussionmentioning

confidence: 99%

“…Both elements play a role in the development of arterial hypertension [37,38]. Deficiency of those metals may disturb the function of SOD and other enzymes, particularly in those that take part in the transport of electrolytes, e.g., the sodium-potassium ATP-ase in erythrocytes [38]. In our study, we did not find statistically significant changes in the activity of SOD in the population exposed to lead, although in the groups with arterial hypertension, the activity of SOD was 10% lower in comparison to Pbnormotensive.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of the Antioxidant Enzymes in Erythrocytes in the Development of Arterial Hypertension among Humans Exposed to Lead

Kasperczyk

Ostałowska

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

(1) lead increases erythrocyte MDA concentration and the activity of GPx as well as SOD in normotensive subjects. (2) Among individuals exposed to lead, with arterial hypertension diagnosed, higher body mass index, age, values of blood lead level, and prolonged exposure to lead have been noticed, accompanied by intensified oxidative stress and the decrease in the activity of glutathione peroxidase in erythrocytes. The reasons for increase of blood pressure in lead exposure remain unrecognized.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Role of the Antioxidant Enzymes in Erythrocytes in the Development of Arterial Hypertension among Humans Exposed to Lead

Kasperczyk

Ostałowska

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Several pumps, ion channels, symporters and antiporters are involved in sodium kinetics in RBC (Canessa, 1989;Alonso et al, 1993;Bernhardt et al, 1999;Ng et al, 2000;Kedzierska et al, 2005;Reifenberger et al, 2007). Among the most important are the sodium-potassium ATPase (Temel & Akyuz, 2007), a second sodium pump (Rocafull et al, 2012;Thomas et al, 2013), a sodium-lithium counter transport (Ng et al, 2000), a sodium-potassium chloride symporter (Plata et al, 2001) and a sodium chloride symporter (Carota et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Red blood cell sodium transport in patients with cirrhosis

Henriksen

Kiszka-Kanowitz

Bendtsen

et al. 2015

Clin Physio Funct Imaging

View full text Add to dashboard Cite

Patients with advanced cirrhosis have abnormal sodium homoeostasis. The study was undertaken to quantify the sodium transport across the plasma membrane of red blood cells (RBC) in patients with cirrhosis. RBC efflux and influx of sodium were studied in vitro with tracer (22) Na(+) according to linear kinetics in 24 patients with cirrhosis and 14 healthy controls. The sodium efflux was modified by ouabain (O), furosemide (F) and a combination of O and F (O + F). RBC sodium was significantly decreased (4·6 versus control 6·3 mmol l(-1) , P<0·001) and directly related to serum sodium (r = 0·57, P<0·05). The RBC fractional sodium efflux was higher in patients with cirrhosis (+46%, P<0·01) compared to controls. Inhibition in both high (145 mmol l(-1) )- and low (120 mmol l(-1) )-sodium buffers showed that the F-insensitive sodium efflux was twice as high in cirrhosis as in controls (P = 0·03-0·007), especially the O-sensitive, F-insensitive efflux was increased (+ 225%, P = 0·01-0·006). Fractional F-sensitive transport was normal in cirrhosis. RBC sodium influx was largely normal in cirrhosis. In conclusion, RBC sodium content is reduced in patients with cirrhosis with a direct relation to serum sodium. Increased RBC sodium efflux is especially related to ouabain-sensitive, furosemide-insensitive transport and thus most likely due to upregulated activity of the sodium-potassium pump. The study gives no evidence to an altered intracellular/extracellular sodium ratio or to a reduced fractional furosemide-sensitive sodium transport in cirrhosis.

show abstract

“…In our previous study [ 6 ] we described an increase of sodium-potassium ATP-ase activity in erythrocytes after lithium treatment in patients with aff ective illnesses, and the possibility of lithium exerting a stimulating eff ect on copper-transporting ATP-ase may be also considered. An interaction between the copper level and the lithium transporting system in erythrocytes was described in another study [ 7 ] . In their recent review, Lutsenko et al [ 8 ] did not mention a role of cations in the regulation of ATP7B, and a possible study of a lithium eff ect in this respect on cellular models (e. g., hepatocytes) could be desirable.…”

mentioning

confidence: 90%

Lithium Treatment of a Bipolar Patient with Wilson's Disease: A Case Report

et al. 2012

View full text Add to dashboard Cite

We present the case of a male patient with a family history of both bipolar disorder (BD) and Wilson's disease (WD). Wilson's disease was diagnosed for this patient in 2008, at the age of 28 years, and shortly thereafter his bipolar illness began with depressive episodes. The patient has been treated with zinc sulphate for WD and with antidepressants for depression. In 2009, lithium was added, and in 2010 antidepressants were discontinued. During treatment with zinc sulphate, a gradual improvement of hepatic indices and a decrease of mandibulofacial dystonia was noted. In 2011, a hypomanic state occurred which subsided with an increase of the lithium dose. Since then, the patient has been mostly in a euthymic mood with subclinical hypomanic periods. We suggest that lithium may be a viable option for treating bipolar illness in patients with Wilson's disease.

show abstract

Copper Modifies the Activity of Sodium-Transporting Systems in Erythrocyte Membrane in Patients with Essential Hypertension

Cited by 12 publications

References 34 publications

The Role of the Antioxidant Enzymes in Erythrocytes in the Development of Arterial Hypertension among Humans Exposed to Lead

The Role of the Antioxidant Enzymes in Erythrocytes in the Development of Arterial Hypertension among Humans Exposed to Lead

Red blood cell sodium transport in patients with cirrhosis

Lithium Treatment of a Bipolar Patient with Wilson's Disease: A Case Report

Contact Info

Product

Resources

About