Copper ion/gallic acid MOFs-laden adhesive pomelo peel sponge effectively treats biofilm-infected skin wounds and improves healing quality

Yang, Jianqiu; Huang, Zhenzhen; Tan, Jiang; Pan, Jingye; Chen, Shixuan; Wan, Wenbing

doi:10.1016/j.bioactmat.2023.10.005

Cited by 11 publications

(7 citation statements)

References 42 publications

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“…For example, copper-containing materials used in the treatment of infected wounds often give priority to the antibacterial properties of the material 66 . In addition, copper-containing materials would also focus on reversing unfavorable pathological features in chronic wounds, such as suppressing excessive inflammation by modulating immunity or scavenging excessive ROS by mimicking enzyme activity 67 , 68 . The released copper ions are then used to promote angiogenesis, granulation tissue formation, collagen deposition and re-epithelialization, thus aiding in chronic wound healing.…”

Section: Copper and Wound Healingmentioning

confidence: 99%

“…The construction of copper-containing hydrogels with anti-inflammatory, antibacterial and antioxidant properties is expected to correct the pathologies that lead to delayed wound healing 65 . Yang et al prepared a multifunctional hydrogel based on decellularized pomelo peel (DPP) coated with PVA-TSPBA hydrogel and doped with antibacterial gallic acid/copper MOFs 68 . DPP had good anti-inflammatory and antioxidant properties, and PVA-TSPBA hydrogel, as a ROS-sensitive hydrogel, could achieve ROS scavenging in wounds.…”

Section: Copper-incorporated Hydrogelsmentioning

confidence: 99%

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Copper incorporated biomaterial-based technologies for multifunctional wound repair

Zhang,

Xue,

Xiong

et al. 2024

Theranostics

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The treatment of wounds is a worldwide challenge, and wound infection can affect the effectiveness of wound treatment and further increase the disease burden. Copper is an essential trace element that has been shown to have broad-spectrum antibacterial effects and to be involved in the inflammation, proliferation, and remodeling stages of wound healing. Compared to treatments such as bioactive factors and skin grafts, copper has the advantage of being low-cost and easily available, and has received a lot of attention in wound healing. Recently, biomaterials made by incorporating copper into bioactive glasses, polymeric scaffolds and hydrogels have been used to promote wound healing by the release of copper ions. In addition, copper-incorporated biomaterials with catalytic, photothermal, and photosensitive properties can also accelerate wound healing through antibacterial and wound microenvironment regulation. This review summarizes the antibacterial mechanisms of copper- incorporated biomaterials and their roles in wound healing, and discusses the current challenges. A comprehensive understanding of the role of copper in wounds will help to facilitate new preclinical and clinical studies, thus leading to the development of novel therapeutic tools.

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Section: Copper and Wound Healingmentioning

confidence: 99%

Section: Copper-incorporated Hydrogelsmentioning

confidence: 99%

Copper incorporated biomaterial-based technologies for multifunctional wound repair

Zhang,

Xue,

Xiong

et al. 2024

Theranostics

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“…In the final step, animals treated with complete formulation did not show visible scar formation and the created wound was healed completely within 4 days. [120]…”

Section: Mofs For Modulating Inflammation and Promoting Healingmentioning

confidence: 99%

MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

Bigham,

Islami,

Khosravi

et al. 2024

Small

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In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds and antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of materials for next‐generation wound healing and dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, and potential for combination therapies make them suitable for complex wound care challenges. MOF‐based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal therapies for skin cancer and infections. Herein, a critical analysis of the current state of research on MOFs and MOF‐based composites for wound healing and dressings is provided, offering valuable insights into the potential applications, challenges, and future directions in this field. This literature review has targeted the multifunctionality nature of MOFs in wound‐disease therapy and healing from different aspects and discussed the most recent advancements made in the field. In this context, the potential reader will find how the MOFs contributed to this field to yield more effective, functional, and innovative dressings and how they lead to the next generation of biomaterials for skin therapy and regeneration.

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“…Thus, the precise and stage-adaptive delivery of copper ions to wound beds is essential for effective bacterial removal and neovascularization. Recent studies have explored diverse approaches to administer copper in wound healing, such as combining hydrogels with copper-based nanoparticles − and metal–organic frameworks. − However, challenges arise from the limited compatibility between the organic hydrogel network and inorganic copper nanomaterials, hindering the uniform distribution and controlled Cu 2+ release.…”

Section: Introductionmentioning

confidence: 99%

A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

Li,

Wang,

Ding

et al. 2024

ACS Nano

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Copper ion/gallic acid MOFs-laden adhesive pomelo peel sponge effectively treats biofilm-infected skin wounds and improves healing quality

Cited by 11 publications

References 42 publications

Copper incorporated biomaterial-based technologies for multifunctional wound repair

Copper incorporated biomaterial-based technologies for multifunctional wound repair

MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

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Copper ion/gallic acid MOFs-laden adhesive pomelo peel sponge effectively treats biofilm-infected skin wounds and improves healing quality

Cited by 11 publications

References 42 publications

Copper incorporated biomaterial-based technologies for multifunctional wound repair

Copper incorporated biomaterial-based technologies for multifunctional wound repair

MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

A Double Network Composite Hydrogel with Self-Regulating Cu2+/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

Contact Info

Product

Resources

About

A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing