Copper(II) complexes of 2-benzoylpyridine 4N-substituted thiosemicarbazones

Tin(IV) complexes of 2‐benzoylpyridine N(4)‐phenyl‐thiosemicarbazone: spectral characterization, structural studies and antifungal activity

“…22 In CDCl 3 , the signals for N3-H were found at δ = 14.05 and δ = 9.87, suggesting the presence of an equivalent mixture of the Z and E forms (80%) together with the E isomer (20%), as observed for other thiosemicarbazones. 8,14 The Z form is present in the solid, as shown by the crystal structure determination of H2Bz4Ph. Moreover, the X-ray diffraction study of complex 3 corroborates the existence of the E isomer (see below).…”

“…1,2 The pharmacological activities of α(N)-heterocyclic thiosemicarbazones derived from 2-formyl and 2-acetylpyridine have been extensively investigated, 3 -6 but much less attention has been given to the 2-benzoylpyridine analogues. For the latter, a few transition metal complexes have been prepared 7,8 and their activity against the human pathogenic fungi Aspergillus niger and Paecilomyces variotii has been demonstrated. 8 On the other hand, tin complexes are known for their biological interest as antitumorals, antibacterials, antifungals and biocides.…”

“…For the latter, a few transition metal complexes have been prepared 7,8 and their activity against the human pathogenic fungi Aspergillus niger and Paecilomyces variotii has been demonstrated. 8 On the other hand, tin complexes are known for their biological interest as antitumorals, antibacterials, antifungals and biocides. 9 -11 Coordination of tin with thiosemicarbazones could, in principle, give complexes with the therapeutic properties of both metals and ligands.…”

N(4)-tolyl-2-benzoylpyridine thiosemicarbazones and their copper(II) complexes with significant antifungal activity: crystal structure of N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone

“…7 Copper(II) complexes of N(4)-substituted 2-benzoylpyridine thiosemicarbazones have been tested against the human pathogenic fungi Aspergillus niger and Paecillomyces variotii. 8 In the present work we describe the preparation of new copper(II) complexes of N(4)-ortho (H2Bz4oT, hereafter named HL1), N(4)-meta (H2Bz4mT, HL2) and N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone (H2Bz4pT, HL3, Figure 1). …”

Synthesis and Biochemical Studies of Transition Metal Complexes of Isatin N(4)-Methyl(phenyl)thiosemicarbazone

“…Among the thiosemicarbazones, those with electron withdrawing substituents at N(4)-position have been studied extensively due to their promising biological and cytotoxic activity [9][10][11][12] . In view of the above literature survey, which revealed the pronounced biological activities of thiosemicarbazone and related compounds of isatin, it is considered worthwhile to report the synthesis and evaluate the biocidal activities of isatin N(4)-methyl(phenyl) thiosemicarbazone as well as its metal(II) complexes.…”