Copper arsenite-complexed Fenton-like nanoparticles as oxidative stress-amplifying anticancer agents

Lee, Giuk; Kim, Chan Woo; Choi, Jeong Ryul; Min, Kyung Hyun; Lee, Hong Jae; Kwack, Kyu Hwan; Lee, Jae Hyung; Jeong, Seo Young; Chang, Kiyuk; Lee, Sang Cheon

doi:10.1016/j.jconrel.2021.12.016

Cited by 16 publications

(8 citation statements)

References 56 publications

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“…Moreover, Lee et al. 441 reported using copper (II) arsenite (CuAS) coupled in the core domains of poly (ethylene glycol)‐ b ‐poly(3,4‐dihydroxy‐ L ‐phenylalanine) to form CuAS‐PMs for CDT treatment of cancer.…”

Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

“…In their results, the tumor growth in U87MG tumor‐bearing mice was significantly inhibited and showed higher rates of apoptosis than control groups after intravenous injection of MS@MnO 2 nanoparticles. Moreover, Lee et al 441 . reported using copper (II) arsenite (CuAS) coupled in the core domains of poly (ethylene glycol)‐ b ‐poly(3,4‐dihydroxy‐ L ‐phenylalanine) to form CuAS‐PMs for CDT treatment of cancer.…”

Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

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Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…However, with the deepening of research, researchers have shown that Cu buildup can potentially result in cell death or irreversible harm to cells, such as cuproptosis, 45–47 apoptosis, 48,49 pyroptosis, 50,51 and ferroptosis 52,53 . In addition, the transformation of Cu 2+ and Cu + sensitizes Fenton‐like reaction and consumes glutathione (GSH), promoting intracellular oxidative stress 54–63 . All of these suggest that Cu ion interference therapy containing Cu exhaustion as well as Cu supplementation has become an attractive therapeutic strategy in anticancer therapy 64–66 .…”

Section: Introductionmentioning

confidence: 99%

“…52,53 In addition, the transformation of Cu 2+ and Cu + sensitizes Fenton-like reaction and consumes glutathione (GSH), promoting intracellular oxidative stress. [54][55][56][57][58][59][60][61][62][63] All of these suggest that Cu ion interference therapy containing Cu exhaustion as well as Cu supplementation has become an attractive therapeutic strategy in anticancer therapy. [64][65][66] It is true that life is Cu and death is Cu.…”

mentioning

confidence: 99%

Nanotechnology connecting copper metabolism and tumor therapy

Dong

Zhou

2023

MedComm – Biomaterials and Applications

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Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism‐based antitumor therapy. Finally, we outline the future directions and challenges of nano‐Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation.

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“…17,18 Although some substantial efforts have revealed that the H 2 O 2 abundance in cancer cells is higher than that in normal cells, its abundance is insufficient to generate adequate ˙OH by Fenton-like reactions for amplifying oxidative stress in the TME. 19,20 Recently, to settle this point of inadequate H 2 O 2 , a large number of studies have been directed toward the delivery of exogenous H 2 O 2 , 21 amplification of endogenous H 2 O 2 , 22 or decomposition of metal peroxides. 23 For example, natural glucose oxidase as a kind of H 2 O 2 producer can greatly amplify H 2 O 2 abundance in the TME.…”

Section: Introductionmentioning

confidence: 99%