Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity

Khadem-Ansari, Mohammad Hassan; Asoudeh, Mojtaba; Gheshlaghi, Hosein Fallahi Kord; Nozari, Samira; Zarringol, Mina; Maroufi, Nazila Fathi; Faridvand, Yousef

doi:10.1515/hmbci-2018-0055

“…[10] The results showed that the level of copper and zinc was significantly increased in patients with MM when compared with healthy control while the results of magnesium and calcium of MM patients were slightly decreased in comparison with healthy control, this result agrees with the results of study conducted by Khadem Ansari et al (2019). [11]…”

Section: Discussionmentioning

confidence: 99%

The Study of Relationship Between Multiple Myeloma and Some Trace Elements in Iraqi Patients

Mohammed

¹

,

Gate

²

2022

Macromolecular Symposia

1

0

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Multiple myeloma (MM) is a disease caused by the malignant plasma cells proliferation through the bone marrow, often without symptoms, the cause of MM disease is unknown. Abnormal antibodies produce by the abnormal plasma cells, which can lead to renal problems and extremely thick blood. The plasma cells can form a mass in the bone marrow soft tissue. The diagnosing of MM is based on finding abnormal antibodies in blood or urine, trace elements are much important to an organism for their cell functions at the chemical, biological, and molecular levels. Examination of trace elements may be useful for diagnosing MM.

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“…Excess Cu may lead to cancer occurrence. Its carcinogenic mechanism may be related to copper zinc superoxide dismutase (Cu/Zn SOD) activating dioxygen and ceruloplasmin to scavenge free radicals by affecting the process of iron metabolism [42,43]. Many types of cancer are characterized by increased intratumoral copper and/or altered systemic copper distribution.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Serum Trace Elements and Oxidative Stress of Patients with Different Types of Cancer

Yang

¹

,

Dai

²

,

Chen

³

et al. 2021

Oxidative Medicine and Cellular Longevity

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Objective. Many studies have identified causal and promotive roles of oxidative stress (OxS) and oxidative damage caused by OxS in the occurrence and progression of cancer. Many biomarkers in the blood circulation of patients may change correspondingly with the development of tumors. This study is aimed at investigating the correlation between OxS and serum trace element (TE) levels of patients with different types of cancer. Methods. 1143 different types of cancer patients and 178 healthy controls from Mar. 2018 to Aug. 2020 in Mianyang Central Hospital were involved in this study. Their levels of OxS parameters (including total oxidant status (TOS), total antioxidant status (TAS), and oxidant stress index (OSI)) and the concentrations of serum TEs (including Cu, Zn, Fe, and Se) were determined. Results. Compared with healthy controls, all types of cancer patients had higher TOS level (all P adj < 0.001 ) and OSI level ( z = 6.228 ~ 9.909 , all P adj < 0.001 ) and lower TAS level (all P adj < 0.001 ). Compared with healthy controls, the changes of four TE levels in serum were different in different types of cancer patients, among which Cu increased in all groups, but there was no statistical difference in gastric and brain cancer; Se decreased in all groups, but there was no statistical difference in gastric, colorectal, esophageal, and other cancer; Zn was significantly decreased in breast cancer patients ( P adj < 0.001 ); there was no statistical difference in the change of Fe in liver, kidney, and other cancer. Spearman correlation showed that the change of Cu concentration was most closely related to the three OxS parameters and was strongly correlated in the observed several types of tumors ( r s > 0.6 ). Multinomial logistic regression showed that the risks of different tumors are related to the level change of multiple TEs and OxS parameters ( OR TOS = 1.19 ~ 2.82 , OR OSI = 2.56 ~ 4.70 , OR TAS = 0.20 ~ 0.46 , OR Cu = 0.73 ~ 1.44 , OR Zn = 0.81 ~ 0.91 , OR Fe = 0.68 ~ 1.18 , and OR Se = 0.22 ~ 0.45 , all P < 0.006 ). Conclusions. The OxS exists in the occurrence and development of cancer, which may be related to the changes of certain trace elements. In order to evaluate OxS correctly, it is necessary to detect TAS and TOS and at the same time, their ratio OSI should be detected. Assessment of markers representing the overall level of OxS and TEs may guarantee improved the monitoring of disease occurrence and development risk in cancer patients.

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“…Subsequently, in 1975, Schwartz highlighted the potential role of copper as a carcinogenic and diagnostic/prognostic marker ( 69 ). Meanwhile, studies found elevated copper serum concentrations in various tumors ( 28 ), such as stage I multiple myeloma ( 29 ), reticulocyte sarcoma, bronchial and laryngeal squamous cell carcinoma, lung cancer ( 31 ), leukaemia, lymphoma ( 70 ), cervical cancer, breast cancer and gastric cancer ( 71 , 72 ). In addition to elevated serum copper levels, elevated copper concentrations were reported in the nails and/or hair of patients with tumors, such as breast, prostate and cervical cancers ( 73 ).…”

Section: The Relationship Between Copper and Tumorsmentioning

confidence: 99%

“…With scientific advances, the abnormal accumulation of copper in cancer cells was found to be an important feature in differentiating them from normal cells. Relevant experimental data showed that several cancer cells maintained trace elements, such as zinc, selenium or iron, at normal levels, but copper levels were significantly elevated ( 28 ), such as in stage I multiple myeloma ( 29 ), lung cancer ( 30 ) and acute lymphoblastic leukaemia ( 31 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between copper and immunity: The potential role of copper in tumor immunity

Fang

¹

,

Geng

²

,

Lu

³

et al. 2022

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Copper is an essential trace element in an organism, and changes in copper levels in vivo often indicate a diseased state. Copper and immunity have been discussed since the last century, with copper deficiency significantly affecting the development and function of the immune system, such as increased host susceptibility to various pathogens, decreased number and impaired function of neutrophils, reduced antibacterial activity of macrophages, decreased proliferation of splenocytes, impaired B cell ability to produce antibodies and impaired function of cytotoxic T lymphocyte and helper T cells. In the past 20 years, some studies have shown that copper ions are related to the development of many tumors, including lung cancer, acute lymphoid leukaemia, multiple myeloma and other tumors, wherein copper ion levels were significantly elevated, and current studies reveal that copper ions are involved in the development, growth and metastasis of tumors through various pathways. Moreover, recent studies have shown that copper ions can regulate the expression of PD-L1, thus, attention should be paid to the important role of copper in tumor immunity. By exploring and studying copper ions and tumor immunity, new insights into tumor immunity could be generated and novel therapeutic approaches to improve the clinical prognosis of patients can be provided.

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Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity

Cited by 13 publications

References 27 publications

The Study of Relationship Between Multiple Myeloma and Some Trace Elements in Iraqi Patients

The Study of Relationship Between Multiple Myeloma and Some Trace Elements in Iraqi Patients

The Relationship between Serum Trace Elements and Oxidative Stress of Patients with Different Types of Cancer

Relationship between copper and immunity: The potential role of copper in tumor immunity

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