Copeptin and NT-proBNP for prediction of all-cause and cardiovascular death in ischemic stroke

Tu, Wen‐Jun; Ma, Guo-Zhao; Ni, Ying; Hu, Xia-Sheng; Luo, Ding-Zhen; Zeng, Xianwei; Liu, Qiang; Xu, Tianmin; Yu, Lie; Wu, Bo-Shui

doi:10.1212/wnl.0000000000003937

Cited by 44 publications

(31 citation statements)

References 32 publications

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“…The endpoints were cardiac events, including CVD death and rehospitalisation for worsening HF. CVD death was identified by the Academic Research Consortium criteria (21) , including death due to CVD such as CHD, congestive HF, sudden cardiac death or fatal stroke. Sudden cardiac death was defined as death without definite premonitory symptoms or signs and confirmed by the attending physician (22) .…”

Section: End Points and Follow-upmentioning

confidence: 99%

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

2019

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There is growing evidence that suggests the association of vitamin D status with the development and progression of heart failure (HF). The objective of the present study is to assess the impact of concentration of serum 25-hydroxyvitamin D (25(OH)D) on cardiac prognosis in patients with HF. Between 1 January 2015 and 31 December 2016, we consecutively recruited patients with HF. Patients were followed prospectively for a median duration of 1 year. Serum concentration of 25(OH)D was measured with competitive chemiluminescent immunoassay. The endpoints were cardiac events, including CVD death and rehospitalisation for worsening HF. Univariate and multivariable adjustments were performed with Cox proportional-hazard regression analyses. The 25(OH)D concentration was obtained in 343 patients with a median value of 17·4 (interquartile range 12·6–23·4) ng/ml. There were 102 cardiac events, including forty-three deaths and fifty-nine rehospitalisations. Multivariate Cox hazard analysis found that the serum concentration 25(OH)D was independently associated with cardiac events (hazard ratio 0·93, 95 % CI 0·88, 0·97) and CVD mortality (hazard ratio 0·83; 95 % CI 0·77, 0·89) after adjustment for confounding factors. We divided the HF patients into four groups according to the 25(OH)D quartiles. Kaplan–Meier analysis found that the patients with lower serum 25(OH)D concentration had a higher risk of cardiac events or CVD mortality than those with high serum 25(OH)D concentration (log-rank test P < 0·001 and P = 0·032). Decreased serum concentrations of 25(OH)D were associated with cardiac prognosis and CVD mortality in a Chinese population with HF independent of other baseline HF markers.

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Section: End Points and Follow-upmentioning

confidence: 99%

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

2019

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“…16 Our data confirm admission PCT values to be associated with SAP and outcome. Previous reports found associations of MRproADM and copeptin with stroke-associated infections 8,12 and functional outcome after stroke. [9][10][11] In a cohort of Chinese patients, copeptin predicted death in patients with ischemic stroke.…”

Section: Resultsmentioning

confidence: 82%

“…9,10 Copeptin, a hypothalamic stress hormone, has been associated with higher risk of all-cause mortality, poor functional outcome after ischemic stroke, and stroke-associated infections. 6,[11][12][13] Midregion pro-atrial natriuretic peptide (ANP) is a marker of hemodynamic stress and has been associated with a higher risk for occurrence of ischemic stroke. 14,15 C-terminal pro-endothelin-1 (CTproET) is a strong vasoconstrictor influenced by age, renal function, and hemodynamic parameters.…”

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confidence: 99%

Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke

Hotter

Höffmann

Ulm

et al. 2020

Neurol Neuroimmunol Neuroinflamm

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ObjectivePrognosis of stroke is negatively affected by complications, in particular stroke-associated pneumonia (SAP). We hypothesized that inflammatory and stress biomarkers predict SAP during hospitalization and outcome 3 months after stroke.MethodsWe pooled the clinical data of 2 acute stroke studies with identical assessment: the STRoke Adverse outcome is associated WIth NoSoKomial Infections (STRAWINSKI) and PREDICT studies. Measurement of biomarkers (ultrasensitive procalcitonin [PCTus]; midregional pro-adrenomedullin; midregional pro-atrial natriuretic peptide [MRproANP]; ultrasensitive copeptin [CPus]; C-terminal pro-endothelin) was performed from serum samples drawn on the first 4 days of hospital admission.ResultsThe combined cohort consists of 573 cases with available backup samples to perform the analysis. SAP was associated with increased admission and maximum levels of all biomarkers. Furthermore, all biomarkers were associated with death and correlated with functional outcome 3 months after stroke. The multivariate logistic regression model retained ultrasensitive CPus and PCTus beyond clinical risk factors for predicting SAP, improving the receiver operating characteristic area under the curve (AUC) from 0.837 to 0.876. In contrast, the biomarkers did not improve the prediction of death and functional outcome in the multivariate model. Cardioembolic strokes were significantly associated with higher values of all biomarkers, whereas discrimination was best for MRproANP (AUC = 0.811 for maximum value).ConclusionsThe tested biomarkers are associated with SAP and poor functional outcome. However, these biomarkers only slightly improve prediction of SAP and do not improve long-term outcome prediction over clinical parameters. MRproANP showed the best discrimination for identifying cardioembolic stroke, warranting further studies to confirm our finding.Clinical trial registrationclinicaltrials.govNCT01264549 and NCT01079728.

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“…Nowadays, many researchers are paying attention to the use of protein biomarkers in patients with ischemic cerebrovascular disease. Therefore, many biomarkers such as small dense low‐density lipoprotein cholesterol, oxidized low‐density lipoprotein, N‐terminal pro‐B‐type natriuretic peptide, interleukin, matrix metalloproteinase‐9, and high‐sensitivity C‐reactive protein have been evaluated for the detection ACI, but no globally recognized biomarkers. In addition, most researchers focus on the value of a single biomarker in ACI, and the combined effects on multiple biomarkers are still less studied.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of lipoprotein‐associated phospholipase A2, serum amyloid A, and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction

Liang

ShiChuan

De-tai

et al. 2019

Clinical Laboratory Analysis

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Objective The aim of this study was to explore the clinical values of combined detection of lipoprotein‐associated phospholipase A2 (Lp‐PLA2), serum amyloid A (SAA), and plasma fibrinogen (FIB) in the diagnosis of acute cerebral infarction (ACI). Methods A case‐control study including 100 hospitalized patients with ACI and 47 healthy controls was carried out. The level of Lp‐PLA2, SAA, and FIB was detected, respectively, and their clinical values were analyzed. Carotid lesions and neurological impairment were also analyzed in each patient. Results The level of Lp‐PLA2, SAA, and FIB in the ACI group was significantly higher than that of the controls, and the three biomarkers showed a significant positive correlation and were considered as risk factors for ACI. The area under the curve (AUC) for Lp‐PLA2, SAA, and FIB was 0.858, 0.743, and 0.672, respectively. When three biomarkers were used in combination, the AUC was 0.879. Compared with the other groups, the levels of three biomarkers in bilateral carotid plaque ACI group were all significantly higher. In addition, the level of Lp‐PLA2 and SAA in ACI patients with severe neurological impairment was also significantly higher than that of the mild‐to‐moderate group. Conclusion Lp‐PLA2 combined with SAA and FIB had a high clinical value for rapid diagnosis and prediction of ACI. These biomarkers were also significantly associated with the formation of bilateral carotid atherosclerotic plaques and the severe neurological impairment in ACI patients.

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Copeptin and NT-proBNP for prediction of all-cause and cardiovascular death in ischemic stroke

Abstract: Copeptin and NT-proBNP may be useful independent prognostic markers of all-cause or CVD mortality in Chinese patients with AIS.

Cited by 44 publications

References 32 publications

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke

Evaluation of lipoprotein‐associated phospholipase A2, serum amyloid A, and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction

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