COPD in Japan: the Nippon COPD Epidemiology study

Fukuchi, Yoshinosuke; Nishimura, Masaharu; Ichinose, Masakazu; Adachi, Mitsuru; Nagai, Atsushi; Kuriyama, Takayuki; Takahashi, K.; Nishimura, Koichi; Ishioka, Shinichi; Aizawa, Hisamichi; Zaher, Carol

doi:10.1111/j.1440-1843.2004.00637.x

Cited by 508 publications

(455 citation statements)

References 23 publications

(21 reference statements)

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“…Study II involved 1-day screening, and validated the data from study I, which was performed over 4 consecutive years. COPD prevalence on the 2 islands was similar (study I vs. II: 9.4 vs. 8.7%) and the findings were in line with that found in a previous study performed on the Japanese mainland (12). Mass screening would encourage the awareness or prevention of COPD, for example, by promoting cessation of smoking; however, the present study found that such screening does not efficiently identify true COPD patients in situations in which the quality and training of examiners is not guaranteed.…”

Section: Discussionsupporting

confidence: 91%

Concerns with the Health Check-up System for Chronic Obstructive Pulmonary Disease on two Japanese Islands

et al. 2011

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Objective Early diagnosis is a key factor in the management of chronic obstructive pulmonary disease (COPD). Although mass screening is widely used, little is known about its accuracy and efficacy. This study investigated whether using spirometry during mass screening to detect COPD among community residents might be ineffective because of variability in the training and experience of examiners. Participants and Methods Both spirometry and a self-written questionnaire-based survey, including questions designed to detect respiratory symptoms, were conducted on community residents. Two separate studies were conducted on islanders living in similar environments. Study I was performed from 2004 to 2007 on Hachijyo Island residents, while study II, with a similar study design, was performed in 2003 on Inno Island residents. Results In study I, 3,592 subjects underwent examination over the 4-year study period; of these, 378 subjects underwent repeated examinations. Approximately 25% of the subjects had respiratory symptoms. Acceptable spirometry recordings were obtained for 62.0% (2004) to 84.1% (2006) of the subjects. In study II, 167 of the 254 subjects (65.7%) had respiratory symptoms. Acceptable assessment recordings were achieved in 254 subjects (95.5%). The suitability of the recordings was influenced by the extent/level of training of the examiners and the accompanying thoracic specialists. Conclusion We concluded that the effectiveness of health check-ups for COPD evaluation using spirometry was greatly influenced by the quality of the examiners, even when the subjects had respiratory symptoms. Thus, we recommend caution when screening for early signs of COPD during health check-ups.

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Section: Discussionsupporting

confidence: 91%

Concerns with the Health Check-up System for Chronic Obstructive Pulmonary Disease on two Japanese Islands

et al. 2011

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“…The Nippon COPD Epidemiology (NICE) Study 84) reported that COPD is an increasingly important health problem in Japan with a prevalence of 8.6% in the Japa-nese population over 40 years of age. The prevalence and burden of COPD are projected to increase in the coming decades as a result of continued exposure to COPD risk factors (mainly cigarette smoke) and the aging of the Japanese population.…”

Section: Resultsmentioning

confidence: 99%

Skeletal muscle dysfunction and oxidative stress in patients with chronic obstructive lung disease

Oh‐ishi

Nemoto

Saito

2015

JPFSM

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Chronic obstructive pulmonary disease (COPD) is an increasingly important global health problem, including Japan. COPD is associated with an enhanced inflammatory response to irritants in the airways and lungs, in particular cigarette smoke. Cigarette smoke contains gaseous and particulate oxidants, and is considered to be the major etiological factor in the development of COPD. The oxidants in cigarette smoke induce inflammation, and chronic inflammation causes narrowing of the small airways and destruction of the lung parenchyma. Inflammation and oxidative stress are intricately related and seem to play a critical role in the development and/or progression of COPD. There is growing evidence that systemic inflammation exists in patients with stable COPD, leading to extra-pulmonary manifestations including skeletal muscle dysfunction and other comorbidities. Oxidative stress is also observed in skeletal muscle of COPD patients. Therefore, both systemic inflammation and oxidative stress may be associated with skeletal muscle dysfunction in COPD patients, resulting in reduced limb muscle strength and exercise endurance and poor health status and quality of life. Pulmonary rehabilitation is important to improve exercise capacity and health-related quality of life for COPD patients. However, physical exercise, the main component of pulmonary rehabilitation, may increase oxidative stress in the skeletal muscle of such patients. Therefore, rehabilitation programs that not only improve exercise capacity and quality of life, but also reduce exerciseinduced oxidative stress should be established in the future.

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“…COPD has high prevalence and mortality, both of which are generally underestimated because many COPD patients are not diagnosed (1)(2)(3). A NICE (Nippon COPD Epidemiology) Study estimated the prevalence of COPD in Japan to be 5,300,000, but the number of patients treated yearly is only 220,000 (2).…”

Section: Spirometry Is Indispensable For the Evaluation Of Pulmonary mentioning

confidence: 99%

“…A NICE (Nippon COPD Epidemiology) Study estimated the prevalence of COPD in Japan to be 5,300,000, but the number of patients treated yearly is only 220,000 (2). Underdiagnosis is thought to result from patients being unaware of the disease until it is advanced, and also from the fact spirometry, the most important tool Division (4)(5)(6) (4)(5)(6).…”

Section: Spirometry Is Indispensable For the Evaluation Of Pulmonary mentioning

confidence: 99%

Validation of "Lung Age" Measured by Spirometry and Handy Electronic FEV1/FEV6 Meter in Pulmonary Diseases

et al. 2009

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COPD in Japan: the Nippon COPD Epidemiology study

Cited by 508 publications

References 23 publications

Concerns with the Health Check-up System for Chronic Obstructive Pulmonary Disease on two Japanese Islands

Concerns with the Health Check-up System for Chronic Obstructive Pulmonary Disease on two Japanese Islands

Skeletal muscle dysfunction and oxidative stress in patients with chronic obstructive lung disease

Validation of "Lung Age" Measured by Spirometry and Handy Electronic FEV1/FEV6 Meter in Pulmonary Diseases

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