2012
DOI: 10.18632/aging.100492 View full text |Buy / Rent full text
|
|

Abstract: Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog of Escherichia coli endonuclease VIII, have overlapping yet distinct substrate specificity. Recently, we reported that OGG1 binds to the Poly(ADP-ribose) polymerase 1 (PARP-1), a DNA damage sensor protei… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
1
1
1
3
31
0

Year Published

2014
2014
2017
2017

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

3
31
0
Order By: Relevance
“…Similarly, PARP1 binds to the glycosylase NEIL1 which stimulates PARylation activity, whereas activated PARP1 inhibits incision activity of NEIL1. Interestingly, and consistent with the notion of compromised DNA repair during aging, PARP1 binds less efficiently to NEIL1 in old mice compared to young ones [94]. Another, important factor in BER/SSBR is the loading platform X-ray repair complementing factor 1 (XRCC1).…”
Section: Dna Repairsupporting
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Similarly, PARP1 binds to the glycosylase NEIL1 which stimulates PARylation activity, whereas activated PARP1 inhibits incision activity of NEIL1. Interestingly, and consistent with the notion of compromised DNA repair during aging, PARP1 binds less efficiently to NEIL1 in old mice compared to young ones [94]. Another, important factor in BER/SSBR is the loading platform X-ray repair complementing factor 1 (XRCC1).…”
Section: Dna Repairsupporting
“…Interaction of hNEIL1 with poly (ADP-ribose) polymerase-1 (PARP-1) [27], a DNA damage sensor, has been observed in vitro and in vivo , and interaction of the C-terminal region of hNEIL1 and the BRCT domain of PARP1 inhibits hNEIL1 incision activity in a concentration-dependent manner. These results suggest that hNEIL1 is not a simple glycosylase/AP-lyase, but plays multiple roles in a highly organized DNA damage control system.…”
Section: Discussionmentioning
“…For example, one of the current hypotheses to explain the age-related NAD decline is that this phenomenon could be mediated by accumulation of DNA damage and activation of PARP1 during aging (Figure 4) (Imai and Guarente, 2014). However, depending on the study, it has been observed that levels and activity of PARPs may either decrease or increase during chronological aging or accelerated aging disorders (Bakondi et al, 2011; Braidy et al, 2011; Noren Hooten et al, 2012; Scheibye-Knudsen et al, 2014; Zhang et al, 2014). For example, it was reported that in Cockayne syndrome (CS), an accelerated aging disorder characterized by progressive neurodegeneration, there is aberrant PARP activation leading to decreased SIRT1 activity and mitochondrial dysfunction (Scheibye-Knudsen et al, 2014).…”
Section: What Causes the Nad Decline Observed During The Aging Process?mentioning