Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, Satchidananda; Antoch, Marina P.; Miller, Brooke H.; Su, Andrew I.; Schook, Andrew B.; Straume, Martin; Schultz, Peter G.; Kay, Steve A.; Takahashi, Joseph S.; Hogenesch, John B.

doi:10.1016/s0092-8674(02)00722-5

Cited by 2,052 publications

(1,904 citation statements)

References 73 publications

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“…Differences in SCN-AVP release could originate at the level of axonal transport and/or release of the AVP peptide at the axon terminal. Indeed, large scale gene expression profiling in mice revealed circadian variation in a number of gene transcripts coding for proteins involved in presynaptic vesicle availability [37]. One possible explanation is that neurons from the S-mice do not receive or do not respond to stimuli for circadian release.…”

Section: Discussionmentioning

confidence: 99%

Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

et al. 2005

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“…DNA microarray studies in mice indicate that ~5-9% of the genome, excluding genes involved in the core clock loop, are under circadian control (Akhtar et al, 2002;Panda et al, 2002;Storch et al, 2002). However, these so-called clock-controlled genes (CCGs) differ among tissues, with any two tissues likely sharing less than 10% of CCGs under circadian control.…”

Section: Direct and Indirect Transcriptional Control As A Clock Outputmentioning

confidence: 99%

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

129

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Hormone secretion is highly organized temporally, achieving optimal biological functioning and health. The master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates the timing of circadian rhythms, including daily control of hormone secretion. In the brain, the SCN drives hormone secretion. In some instances, SCN neurons make direct synaptic connections with neurosecretory neurons. In other instances, SCN signals set the phase of "clock genes" that regulate circadian function at the cellular level within neurosecretory cells. The protein products of these clock genes can also exert direct transcriptional control over neuroendocrine releasing factors. Clock genes and proteins are also expressed in peripheral endocrine organs providing additional modes of temporal control. Finally, the SCN signals endocrine glands via the autonomic nervous system, allowing for rapid regulation via multisynaptic pathways. Thus, the circadian system achieves temporal regulation of endocrine function by a combination of genetic, cellular, and neural regulatory mechanisms to ensure that each response occurs in its correct temporal niche. The availability of tools to assess the phase of molecular/cellular clocks and of powerful tract tracing methods to assess connections between "clock cells" and their targets provides an opportunity to examine circadian-controlled aspects of neurosecretion, in the search for general principles by which the endocrine system is organized. KeywordsCircadian; Diurnal; Endocrinel; Neurosecretion; Clock genes; Suprachiasmatic Circadian aspects of reproductionThe importance of circadian (about a day) timing in hormone production/secretion has been known since the 1950s when Everett and Sawyer determined that a stimulatory signal occurring during a narrow temporal window on the afternoon of proestrus is necessary for induction of ovulation later that night (Everett and Sawyer, 1950). Such close temporal organization is important for successful reproduction, as numerous hormone-dependent behavioral and physiological processes must be coordinated. If optimal temporal relationships are disrupted, pronounced deficits in fertility can result. For example, ovulation, behavioral estrus, fertilization, and pregnancy maintenance require a specific

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“…Rhythmic mRNA expression has mostly been characterized by analyzing temporal changes of steady-state mRNA levels, using techniques such as microarrays (e.g., McDonald and Rosbash, 2001; Panda et al, 2002; Storch et al, 2002) and more recently high-throughput sequencing (Hughes et al, 2012). It is generally assumed that these rhythms in mRNA expression directly result from temporal changes in transcription.…”

Section: Introductionmentioning

confidence: 99%

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

Menet

Rodriguez

Abruzzi

et al. 2012

eLife

280

395

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A substantial fraction of the metazoan transcriptome undergoes circadian oscillations in many cells and tissues. Based on the transcription feedback loops important for circadian timekeeping, it is commonly assumed that this mRNA cycling reflects widespread transcriptional regulation. To address this issue, we directly measured the circadian dynamics of mouse liver transcription using Nascent-Seq (genome-wide sequencing of nascent RNA). Although many genes are rhythmically transcribed, many rhythmic mRNAs manifest poor transcriptional rhythms, indicating a prominent contribution of post-transcriptional regulation to circadian mRNA expression. This analysis of rhythmic transcription also showed that the rhythmic DNA binding profile of the transcription factors CLOCK and BMAL1 does not determine the transcriptional phase of most target genes. This likely reflects gene-specific collaborations of CLK:BMAL1 with other transcription factors. These insights from Nascent-Seq indicate that it should have broad applicability to many other gene expression regulatory issues.DOI: http://dx.doi.org/10.7554/eLife.00011.001

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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Cited by 2,052 publications

References 73 publications

Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

The regulation of neuroendocrine function: Timing is everything

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

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