Coordinated Regulation of Mesenchymal Stem Cell Migration by Various Chemotactic Stimuli

Nam, Dong Hyun; Park, Aran; Dubon, Maria Jose; Yu, Jinyeong; Kim, Wootak; Son, Youngsook; Park, Ki‐Sook

doi:10.3390/ijms21228561

Cited by 14 publications

(4 citation statements)

References 30 publications

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“…The main ones involved in the chemotactic process are chemokines and their receptors, pro-inflammatory cytokines, and growth factors. 75 Chemokines and their receptors mainly include CXCR1-6, CCR1/2/4/6/8/9, MCP-1, MIP-1α, and SDF-1. Pro-inflammatory cytokines such as IL-3, IL-6, IL-8, IL-1β, TGF-β, IGF-1, and TNF-α, as well as growth factors such as VEGF, PDGF, EGF, FGF, HGF, IGF, and SCF, are released from the site of injury to provide chemotaxis signals for MSCs to attract them to the designated location.…”

Section: Factors Influencing the Homing Processmentioning

confidence: 99%

Bioactive Materials That Promote the Homing of Endogenous Mesenchymal Stem Cells to Improve Wound Healing

Jiang,

Chen,

Huang

et al. 2024

IJN

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Endogenous stem cell homing refers to the transport of endogenous mesenchymal stem cells (MSCs) to damaged tissue. The paradigm of using well-designed biomaterials to induce resident stem cells to home in to the injured site while coordinating their behavior and function to promote tissue regeneration is known as endogenous regenerative medicine (ERM). ERM is a promising new avenue in regenerative therapy research, and it involves the mobilizing of endogenous stem cells for homing as the principal means through which to achieve it. Comprehending how mesenchymal stem cells home in and grasp the influencing factors of mesenchymal stem cell homing is essential for the understanding and design of tissue engineering. This review summarizes the process of MSC homing, the factors influencing the homing process, analyses endogenous stem cell homing studies of interest in the field of skin tissue repair, explores the integration of endogenous homing promotion strategies with cellular therapies and details tissue engineering strategies that can be used to modulate endogenous homing of stem cells. In addition to providing more systematic theories and ideas for improved materials for endogenous tissue repair, this review provides new perspectives to explore the complex process of tissue remodeling to enhance the rational design of biomaterial scaffolds and guide tissue regeneration strategies.

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Section: Factors Influencing the Homing Processmentioning

confidence: 99%

Bioactive Materials That Promote the Homing of Endogenous Mesenchymal Stem Cells to Improve Wound Healing

Jiang,

Chen,

Huang

et al. 2024

IJN

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“…Other growth factors, such as glial cell-derived neurotrophic factor (GDNF) [22] and insulin-like growth factor-binding protein 5 (IGFBP5), promoted DPSC migration and enhanced the osteo/odontogenic and neurogenic differentiation of DPSCs [43]. Injured tissues can secrete the neuropeptide substance P (SP), which may exert immunomodulatory and stem cell recruitment roles [118,119]. Very recently, SP has been implicated in the odontoblastic differentiation of DPSCs during the reparative genesis of dentin.…”

Section: The Hdpsc Fatementioning

confidence: 99%

The Migration and the Fate of Dental Pulp Stem Cells

Lampiasi

2023

Biology

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Human dental pulp stem cells (hDPSCs) are adult mesenchymal stem cells (MSCs) obtained from dental pulp and derived from the neural crest. They can differentiate into odontoblasts, osteoblasts, chondrocytes, adipocytes and nerve cells, and they play a role in tissue repair and regeneration. In fact, DPSCs, depending on the microenvironmental signals, can differentiate into odontoblasts and regenerate dentin or, when transplanted, replace/repair damaged neurons. Cell homing depends on recruitment and migration, and it is more effective and safer than cell transplantation. However, the main limitations of cell homing are the poor cell migration of MSCs and the limited information we have on the regulatory mechanism of the direct differentiation of MSCs. Different isolation methods used to recover DPSCs can yield different cell types. To date, most studies on DPSCs use the enzymatic isolation method, which prevents direct observation of cell migration. Instead, the explant method allows for the observation of single cells that can migrate at two different times and, therefore, could have different fates, for example, differentiation and self-renewal. DPSCs use mesenchymal and amoeboid migration modes with the formation of lamellipodia, filopodia and blebs, depending on the biochemical and biophysical signals of the microenvironment. Here, we present current knowledge on the possible intriguing role of cell migration, with particular attention to microenvironmental cues and mechanosensing properties, in the fate of DPSCs.

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“…Similarly, TNF-α preconditioned MSC could better migrate in vitro toward selected chemokines such as the above-mentioned SDF-1, but this effect could not be correlated to CXCR4 expression levels[ 93 ]. In parallel, migration of MSC was also shown to be enhanced by exposure to transforming growth factor beta (TGF-β)[ 94 ], even though, in other studies[ 95 ], the same cytokine was also shown to downregulate migration of MSCs in response to SDF-1 stimuli. Interestingly, pre-exposure of MSC to TGF-β resulted in enhanced CXCR4 mediated migration toward glioblastoma cells[ 96 ].…”

Section: Msc Homing Improvement Strategiesmentioning

confidence: 99%

Modified mesenchymal stem cells in cancer therapy: A smart weapon requiring upgrades for wider clinical applications

Vicinanza¹,

Lombardi²,

Ros³

et al. 2022

WJSC

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Mesenchymal stem stromal cells (MSC) are characterized by the intriguing capacity to home toward cancer cells after systemic administration. Thus, MSC can be harnessed as targeted delivery vehicles of cytotoxic agents against tumors. In cancer patients, MSC based advanced cellular therapies were shown to be safe but their clinical efficacy was limited. Indeed, the amount of systemically infused MSC actually homing to human cancer masses is insufficient to reduce tumor growth. Moreover, induction of an unequivocal anticancer cytotoxic phenotype in expanded MSC is necessary to achieve significant therapeutic efficacy. Ex vivo cell modifications are, thus, required to improve anti-cancer properties of MSC. MSC based cellular therapy products must be handled in compliance with good manufacturing practice (GMP) guidelines. In the present review we include MSC-improving manipulation approaches that, even though actually tested at preclinical level, could be compatible with GMP guidelines. In particular, we describe possible approaches to improve MSC homing on cancer, including genetic engineering, membrane modification and cytokine priming. Similarly, we discuss appropriate modalities aimed at inducing a marked cytotoxic phenotype in expanded MSC by direct chemotherapeutic drug loading or by genetic methods. In conclusion, we suggest that, to configure MSC as a powerful weapon against cancer, combinations of clinical grade compatible modification protocols that are currently selected, should be introduced in the final product. Highly standardized cancer clinical trials are required to test the efficacy of ameliorated MSC based cell therapies.

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Coordinated Regulation of Mesenchymal Stem Cell Migration by Various Chemotactic Stimuli

Cited by 14 publications

References 30 publications

Bioactive Materials That Promote the Homing of Endogenous Mesenchymal Stem Cells to Improve Wound Healing

Bioactive Materials That Promote the Homing of Endogenous Mesenchymal Stem Cells to Improve Wound Healing

The Migration and the Fate of Dental Pulp Stem Cells

Modified mesenchymal stem cells in cancer therapy: A smart weapon requiring upgrades for wider clinical applications

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