Cooperative effects in CdSe/ZnS-PEGOH quantum dot luminescence quenching by a water soluble porphyrin

Borissevitch, Iouri; Parra, Gustavo G.; Zagidullin, V. E.; Лукашев, Е. П.; Knox, P. P.; Paschenko, V.Z.; Rubin, A. B.

doi:10.1016/j.jlumin.2012.09.008

Cited by 24 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The binding constant was similar to that for the binding of nonfunctional porphyrin to the gold nanosurface, as investigated by Shaikh et al, and for the interaction of TPPS to magnetic iron oxide nanoparticles and other nanosystems. 27 , 37 , 42 − 44 It is likely that porphyrin got adsorbed on the AuNP surfaces through the coordination interaction between gold and pyrrolic nitrogen atoms of the porphyrin ring and formed a strong association complex.…”

Section: Resultsmentioning

confidence: 99%

Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

et al. 2018

View full text Add to dashboard Cite

With an aim to overcome multidrug resistance (MDR), nontargeted delivery, and drug toxicity, we developed a new nanochemotherapeutic system with tetrasodium salt of meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) armored on gold nanoparticles (TPPS-AuNPs). The nanocarrier is able to be selectively internalized within tumor cells than in normal cells followed by endocytosis and therefore delivers the antitumor drug doxorubicin (DOX) particularly to the nucleus of diseased cells. The embedment of TPPS on the gold nanosurface provides excellent stability and biocompatibility to the nanoparticles. Porphyrin interacts with the gold nanosurface through the coordination interaction between gold and pyrrolic nitrogen atoms of the porphyrin and forms a strong association complex. DOX-loaded nanocomposite (DOX@TPPS-AuNPs) demonstrated enhanced cellular uptake with significantly reduced drug efflux in MDR brain cancer cells, thereby increasing the retention time of the drug within tumor cells. It exhibited about 9 times greater potency for cellular apoptosis via triggered release commenced by acidic pH. DOX has been successfully loaded on the porphyrin-modified gold nanosurface noncovalently with high encapsulation efficacy (∼90%) and tightly associated under normal physiological conditions but capable of releasing ∼81% of drug in a low-pH environment. Subsequently, DOX-loaded TPPS-AuNPs exhibited higher inhibition of cellular metastasis, invasion, and angiogenesis, suggesting that TPPS-modified AuNPs could improve the therapeutic efficacy of the drug molecule. Unlike free DOX, drug-loaded TPPS-AuNPs did not show toxicity toward normal cells. Therefore, higher drug encapsulation efficacy with selective targeting potential and acidic-pH-mediated intracellular release of DOX at the nucleus make TPPS-AuNPs a “magic bullet” for implication in nanomedicine.

show abstract

Section: Resultsmentioning

confidence: 99%

Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The electro-kinetic potential of TPPS 4 and CuInS/ZnS QDs were measured and found to be −36.4 mV and −74.8 mV, respectively. The negative charge on TPPS 4 is attributed to the sulfonate phenyl groups in its structure11,26,27 while the net negative charge on the surface of the QDs suggests some degree of deprotonation on its surface. This implies a low probable electrostatic attraction between QDs-GSH groups and TPPS 4 molecules.…”

Section: Resultsmentioning

confidence: 99%

“…In addressing these inherent shortcomings of TPPS 4 and porphyrins at large, much research has focused on conjugated systems for their biological applications 8,9,11. Moreover, conjugation of TPPS 4 has shown to improve the QY of QDs and disaggregation of aged QDs which allows for a wider application range of TPPS 4 –nanomaterial conjugates 9.…”

Section: Introductionmentioning

confidence: 99%

<p>Synthesis of meso-tetra-(4-sulfonatophenyl) porphyrin (TPPS<sub>4</sub>) – CuInS/ZnS quantum dots conjugate as an improved photosensitizer</p>

Tsolekile

Ncapayi

Obiyenwa

et al. 2019

IJN

View full text Add to dashboard Cite

Background Metal-free, water-soluble and highly stable meso-tetra-(4-sulfonatophenyl) porphyrin (TPPS 4 ) has been studied for their singlet oxygen quantum yield. However, TPPS 4 suffers from inherent shortcomings. To address these, TPPS 4 was conjugated to ternary copper indium sulphide/ zinc sulphide (CuInS 2 /ZnS) quantum dots (QDs). Purpose We herein report for the first time the synthesis of TPPS 4 –CuInS/ZnS QDs conjugate as an improved photosensitizer. Methods Water-soluble TPPS 4 was synthesized from tetraphenylporphyrin (TPPH 2 ) after silica-gel purification. The CuInS/ZnS QDs were synthesized by hydrothermal method at a Cu:In ratio of 1:4. The porphyrin–QDs conjugate was formed via the daggling sulfonyl bond of the porphyrin and amine bond of the QDs. The effect of pH on the optical properties of TPPS 4 was evaluated. The effect of Zn:Cu + In ratio on the ZnS shell passivation was examined to reduce structural defects on the as-synthesized QDs. Results: Various spectroscopic techniques were used to confirm the successful conversion of the organic TPPH 2 to water-soluble TPPS 4 . The singlet oxygen generation evaluation shows an improved singlet oxygen quantum yield from 0.19 for the porphyrin (TPPS 4 ) alone to 0.69 after conjugation (CuInS/ZnS-TPPS 4 ) with an increase in the reaction rate constant (k (s-1)).

show abstract

“…Interaction between TPPS 4 and QD via energy and/or charge transfer has already been documented [ 16 ]. Commonly, these processes are accompanied by reduction in the QD luminescence intensity and lifetime.…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Cysteine-Coated CdSe/ZnS Quantum Dot Luminescence by meso-Tetrakis (p-sulfonato-phenyl) Porphyrin

et al. 2018

View full text Add to dashboard Cite

Interaction between porphyrins and quantum dots (QD) via energy and/or charge transfer is usually accompanied by reduction of the QD luminescence intensity and lifetime. However, for CdSe/ZnS-Cys QD water solutions, kept at 276 K during 3 months (aged QD), the significant increase in the luminescence intensity at the addition of meso-tetrakis (p-sulfonato-phenyl) porphyrin (TPPS4) has been observed in this study. Aggregation of QD during the storage provokes reduction in the quantum yield and lifetime of their luminescence. Using steady-state and time-resolved fluorescence techniques, we demonstrated that TPPS4 stimulated disaggregation of aged CdSe/ZnS-Cys QD in aqueous solutions, increasing the quantum yield of their luminescence, which finally reached that of the fresh-prepared QD. Disaggregation takes place due to increase in electrostatic repulsion between QD at their binding with negatively charged porphyrin molecules. Binding of just four porphyrin molecules per single QD was sufficient for total QD disaggregation. The analysis of QD luminescence decay curves demonstrated that disaggregation stronger affected the luminescence related with the electron-hole annihilation in the QD shell. The obtained results demonstrate the way to repair aged QD by adding of some molecules or ions to the solutions, stimulating QD disaggregation and restoring their luminescence characteristics, which could be important for QD biomedical applications, such as bioimaging and fluorescence diagnostics. On the other hand, the disaggregation is important for QD applications in biology and medicine since it reduces the size of the particles facilitating their internalization into living cells across the cell membrane.Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2449-x) contains supplementary material, which is available to authorized users.

show abstract

Cooperative effects in CdSe/ZnS-PEGOH quantum dot luminescence quenching by a water soluble porphyrin

Cited by 24 publications

References 34 publications

Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

<p>Synthesis of meso-tetra-(4-sulfonatophenyl) porphyrin (TPPS<sub>4</sub>) – CuInS/ZnS quantum dots conjugate as an improved photosensitizer</p>

Stimulation of Cysteine-Coated CdSe/ZnS Quantum Dot Luminescence by meso-Tetrakis (p-sulfonato-phenyl) Porphyrin

Contact Info

Product

Resources

About