2010
DOI: 10.1182/blood-2010-06-289314
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Abstract: IntroductionLocal and systemic coagulation activation is a hallmark of advanced malignancies. 1,2 Cancer cell-expressed tissue factor (TF) is a major procoagulant stimulus in cancer-associated thrombosis, and tumor cell TF expression is correlated with tumor progression in several experimental tumor models (reviewed in Schaffner and Ruf 3 ). Although thrombin generated in the course of coagulation supports hematogenous metastasis 4 and regulates angiogenesis and the tumor microenvironment, 5 several lines of p… Show more

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Cited by 93 publications
(114 citation statements)
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“…The membrane-bound full-length tf-fviia complex, coupled with cell surface integrins, triggers signalling through an interplay between proteaseactivated receptor 2 cleavage and tf cytoplasmic domain phosphorylation 22,23 . Those signalling pathways modulate angiogenesis and tumour growth.…”
Section: 11mentioning
confidence: 99%
“…The membrane-bound full-length tf-fviia complex, coupled with cell surface integrins, triggers signalling through an interplay between proteaseactivated receptor 2 cleavage and tf cytoplasmic domain phosphorylation 22,23 . Those signalling pathways modulate angiogenesis and tumour growth.…”
Section: 11mentioning
confidence: 99%
“…signaling has been demonstrated in both murine and human cells (23,48,49), little is known about signaling of the ternary complex in primary cells isolated from mice. Because TF is not typically expressed by endothelial cells in the absence of proangiogenic or inflammatory stimuli, we focused on murine SMCs that constitutively express EPCR and TF (50,51).…”
Section: Epcr Is a Conserved Component Of Ternary Signaling Complex Amentioning
confidence: 99%
“…Indeed, previous studies have shown that in vitro and in vivo phenotypes such as motility, invasiveness, and growth of MDA-MB-231 cells are highly TF-dependent [26][27][28][29][30] . Moreover, in these cells, TF has been shown to act as an angiogenic switch, leading to breast tumor development in a spontaneous breast cancer model recapitulating the human disease [31,32] .…”
Section: Cancer Cellsmentioning
confidence: 99%
“…It was found that the phosphorylation of TF in association with PAR2 expression correlates with breast cancer recurrence [89] . In addition, in vivo studies using TF cytoplasmic domain-deleted mice revealed interplay between the TF cytoplasmic domain and PAR2 signaling, to promote breast cancer by modulating the host angiogenic response [32] . These studies provide a mechanism for the observed clinical association between TF phosphorylation and PAR2 signaling.…”
Section: Tf Expression and Its Association With Breast Cancer Patientmentioning
confidence: 99%