Convulsions in weanling rabbits after a single topical application of 1% lindane

Hanig, Joseph P.; Yoder, Paige; Krop, Stephen

doi:10.1016/0041-008x(76)90177-0

Cited by 14 publications

(1 citation statement)

References 10 publications

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“…Pharmacological studies with high doses of HCH show altered muscle tremors, convulsions, electroencephalogramme modification and somatomotor or somato-sensitive response in mammals (Hanig et al 1976;Stein et al 1981;Joy 1982). Recent studies on rat brain synaptosomes suggested HCH interaction with GABAergic neurotransmission (Stein et al 1981) with picrotoxin receptor (Matsumura & Ghiasuddin 1983) and increases the Ca++-uptake (Narbonne & Lievrmont 1983) establishing a link between lindane and Ca+ + equilibrium.…”

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confidence: 99%

Effects of Hexachlorocyclohexane (HCH) on the Contractile Response Induced by Norepinephrine in the Rat Isolated Vas deferens

Gandhi

Venkatakrishna‐Bhatt

1989

Pharmacology & Toxicology

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Effects of hexachlorocyclohexane (Technical HCH) on the contractile responses of rat isolated Vas deferens to norepinephrine (NE) were investigated by varying the Ca++ and Mg++ concentrations of the incubation medium. Preparations incubated in excess Ca++ (4.2 mM) or in Ca++-free Krebs solution showed decrease in sensitivity to NE. The inhibitory action of HCH reduced the sensitivity and decreased maximum responses to NE in any Mg++ concentration of the medium. In the normal Ca++ and its deficient medium decrease in sensitivity to HCH and the relevant maximum response to NE were observed. In excess Ca++, the HCH effect depressed corresponding to its maximal response to NE. The presence of EDTA depressed the HCH effect irrespective of the Ca++ influence on the receptors.

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confidence: 99%

Effects of Hexachlorocyclohexane (HCH) on the Contractile Response Induced by Norepinephrine in the Rat Isolated Vas deferens

Gandhi

Venkatakrishna‐Bhatt

1989

Pharmacology & Toxicology

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Lindan [MAK Value Documentation in German language, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 27. Lieferung, Ausgabe 1998 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Lindane [MAK Value Documentation, 2001]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 16 (2001) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Man Single exposures Repeated exposure Allergenic effects Genotoxicity Carcinogenicity Animal Experiments and in vitro Studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Allergenic effects Reproductive and developmental toxicity Genotoxicity Carcinogenicity Other effects Manifesto (MAK value/classification)

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Convulsions in weanling rabbits after a single topical application of 1% lindane

Cited by 14 publications

References 10 publications

Effects of Hexachlorocyclohexane (HCH) on the Contractile Response Induced by Norepinephrine in the Rat Isolated Vas deferens

Effects of Hexachlorocyclohexane (HCH) on the Contractile Response Induced by Norepinephrine in the Rat Isolated Vas deferens

Lindan [MAK Value Documentation in German language, 1998]

Lindane [MAK Value Documentation, 2001]

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