Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways

Dowell, Paul; Otto, Tamara C.; Adi, Saleh; Lane, M. Daniel

doi:10.1074/jbc.m309069200

Cited by 214 publications

(193 citation statements)

References 54 publications

(66 reference statements)

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“…These findings suggest several possibilities that (1) FoxO1 in adipose tissues may have many target genes and up-or down-regulate their expression in insulin resistant state or (2) FoxO1 can regulate expression or activity of one or two signaling molecules at transcriptional level or through proteinprotein interaction and can regulate expression of genes in adipose tissues as a whole. Dowell et al described an antagonistic relationship between FoxO1 and Pparc where FoxO1 decreased the formation of a Pparc/Rxr/DNA complex [93]. Therefore, reducing FoxO1 mRNA expression may lead to improvements in Pparc activity.…”

Section: Adipose Tissuesmentioning

confidence: 99%

The FoxO transcription factors and metabolic regulation

2007

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Forkhead transcription factors FoxOs are conserved beyond species and regulated by insulin signaling pathway. FoxOs have diverse functions on differentiation, proliferation and cell survival. In calorie restriction (CR) or starvation, FoxOs are in nucleus, active transcriptionally, and increase hepatic glucose production, decrease insulin secretion, increase food intake and cause degradation of skeletal muscle for supplying substrates for glucose production. However, even in insulin resistance due to excessive calorie intake, FoxOs are active and causes type 2 diabetes and hyperlipidemia. The understanding of molecular mechanism how FoxOs affect glucose or lipid metabolism will shed light on the novel therapy of type 2 diabetes and the metabolic syndrome.

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Section: Adipose Tissuesmentioning

confidence: 99%

The FoxO transcription factors and metabolic regulation

2007

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“…Peroxisome proliferator-activated receptor-g also inhibits FoxO-dependent transcription by directly binding to FoxO in mammalian cells (Dowell et al, 2003). The inhibitory effect of nuclear receptors on FoxO-dependent transcription extends to other members of this family.…”

Section: Regulation Of Foxo-dependent Transcription: Interaction Withmentioning

confidence: 99%

The FoxO code

2008

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“…PPARg is an important regular of adipocyte differentiation and the observation that FOXO1 binding to PPARg antagonized PPARg function could explain the FOXO1-mediated differentiation block. One proposed mechanism by which FOXO1 could inhibit PPARg function is through disrupting formation of a PPARg/RXR complex resulting in loss of DNA binding (Dowell et al, 2003). Reducing transcription of the glucose reporter GLUT4 by PPARg can lead to a decrease in insulin sensitivity in adipocytes (Armoni et al, 2003).…”

Section: Regulation Of Glucose and Fatty Acid Metabolism By Foxo-intementioning

confidence: 99%

FOXO-binding partners: it takes two to tango

van der Vos,

Coffer

2008

Oncogene

187

161

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Modulation FOXO transcription factor activities can lead to a variety of cellular outputs resulting in changes in proliferation, apoptosis, differentiation and metabolic responses. Although FOXO proteins all contain an identical DNA-binding domain their cellular functions appear to be distinct, as exemplified by differences in the phenotype of Foxo1, Foxo3 and Foxo4 null mutant mice. While some of these differences may be attributable to the differential expression patterns of these transcription factors, many cells and tissues express several FOXO isoforms. Recently it has become clear that FOXO proteins can regulate transcriptional responses independently of direct DNA-binding. It has been demonstrated that FOXOs can associate with a variety of unrelated transcription factors, regulating activation or repression of diverse target genes. The complement of transcription factors expressed in a particular cell type is thus critical in determining the functional end point of FOXO activity. These interactions greatly expand the possibilities for FOXO-mediated regulation of transcriptional programmes. This review details currently described FOXO-binding partners and examines the role of these interactions in regulating cell fate decisions.

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Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways

Abstract: The forkhead factor Foxo1 (or FKHR) was identified in a yeast two-hybrid screen as a peroxisome proliferator-activated receptor (PPAR) ␥-interacting protein.

Cited by 214 publications

References 54 publications

The FoxO transcription factors and metabolic regulation

The FoxO transcription factors and metabolic regulation

The FoxO code

FOXO-binding partners: it takes two to tango

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