Convergence of adipocyte hypertrophy, telomere shortening and hypoadiponectinemia in obese subjects and in patients with type 2 diabetes

Monickaraj, Finny; Gokulakrishnan, Kuppan; Prabu, Paramasivam; Chandrakumar, Sathishkumar; Anjana, Ranjit Mohan; Rajkumar, J. S.; Mohan, Viswanathan; Balasubramanyam, Muthuswamy

doi:10.1016/j.clinbiochem.2012.07.097

Cited by 52 publications

(47 citation statements)

References 38 publications

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“…The difficulty in comparing these studies is that historically telomere length is measured using leukocyte DNA, whereas the use of hVAT DNA may not show the same telomeric senescence, primarily due to cell turnaround time and antioxidant capacity. Recent studies by Moreno-Navarrete et al [25] and Monickaraj et al [26], looked at the measurement of telomere length in adipose tissue reporting shortened telomeres in subjects with obesity and diabetes. A significantly high percentage of subjects in the ODM group were receiving statin treatment, which has been observed to have a positive impact on telomere length, showing a protective effect against oxidative stress [27].…”

Section: Discussionmentioning

confidence: 98%

Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes

Jones

Prior

Barry

et al. 2014

Diabetes Research and Clinical Practice

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Section: Discussionmentioning

confidence: 98%

Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes

Jones

Prior

Barry

et al. 2014

Diabetes Research and Clinical Practice

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“…Similar results were obtained in female and male Indians when adjusting for BMI, BFM, waist circumference, total and SC adipose tissue area 48 . Another study found an association between fasting glycemia, HOMA-IR 63 and OM FCS; however, statistical adjustment for anthropometric values was not performed in that study 52 .…”

Section: Glucose Homeostasis Insulin Resistance and T2dmmentioning

confidence: 95%

“…A number of studies have shown a clear association between abdominal SC FCS and markers of insulin resistance, in both women and men 11,15,24,45,[49][50][51][52][53][54] . In overweight South African women with normal glucose tolerance (NGT), no link was found between abdominal or gluteofemoral SC FCS and insulin resistance markers such as basal plasma insulin, insulin area and glucose area after a 100 g oral glucose load 55 .…”

Section: Glucose Homeostasis Insulin Resistance and T2dmmentioning

confidence: 99%

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

Laforest¹,

Labrecque²,

Michaud³

et al. 2015

Critical Reviews in Clinical Laboratory Sciences

175

148

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Obesity is a heterogeneous disease and is associated with comorbidities such as type 2 diabetes mellitus, cardiovascular disease and cancer. Several studies have examined the role of dysfunctional adipose tissue in the pathogenesis of obesity, highlighting the contrasting properties and impact of distinct fat compartments, sometimes with contradictory results. Dysfunctional adipose tissue involves enlargement, or hypertrophy, of pre-existing fat cells, which is thought to confer increases in cardiometabolic risk, independent of the level of obesity per se. In this article, we critically analyze available literature that examined the ability of adipocyte cell size to predict metabolic disease and adipose tissue dysfunction in humans. Many studies demonstrate that increased fat cell size is a significant predictor of altered blood lipid profiles and glucose-insulin homeostasis independent of adiposity indices. The contribution of visceral adiposity to these associations appears to be of particular importance. However, available studies are not unanimous and many fat depot-specific aspects of the relationship between increased fat cell size and cardiometabolic risk or parameters of adipose tissue dysfunction are still unresolved. Methodological factors such as the approach used to express the data may represent significant confounders in these studies. Additional studies should consider the fact that the relationship between fat cell size and common adiposity indices is non-linear, particularly when reaching the obese range. In conclusion, our analysis demonstrates that fat cell size is a significant predictor of the cardiometabolic alterations related to obesity. We propose that adipocyte hypertrophy, especially in the visceral fat compartment, may represent a strong marker of limited hyperplasic capacity in subcutaneous adipose tissues, which in turn is associated with the presence of numerous cardiometabolic alterations.

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“…Another mechanism could be that telomeric DNA damage leads to compromised mitochondrial functioning through dampened p53 expression, eventually causing less fatty acid oxidation and glucose utilization, and less protection against oxidative stress (45). Additionally, shortened telomeres are also associated with adipocyte hypertrophy, which in turn are found to be linked to poor glycemic and lipid control (9).…”

mentioning

confidence: 98%

Telomere Length as a Marker of Cellular Aging Is Associated With Prevalence and Progression of Metabolic Syndrome

Révész

Milaneschi

Verhoeven

et al. 2014

The Journal of Clinical Endocrinology & Metabolism

109

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Convergence of adipocyte hypertrophy, telomere shortening and hypoadiponectinemia in obese subjects and in patients with type 2 diabetes

Cited by 52 publications

References 38 publications

Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes

Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

Telomere Length as a Marker of Cellular Aging Is Associated With Prevalence and Progression of Metabolic Syndrome

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