Conventional and hybrid nanoparticulate systems for the treatment of hepatocellular carcinoma: An updated review

Kabil, Mohamed Fawzi; Nasr, Maha; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ejpb.2021.07.003

Cited by 12 publications

(2 citation statements)

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“…To manage the quality of LBNPs and ensure that they meet the requirements of diverse applications, proper characterization of LBNPs is essential ( 42 ). Particle size and polydispersity index (PDI), ZP, surface shape, encapsulation efficiency (EE), drug release, crystallinity, and nanoparticle stability are crucial LBNP features that must be thoroughly characterized ( 43 ). As a bioactive delivery system, LBNPs have more advantages.…”

Section: Classification Of Lbnpsmentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced for the treatment of cancer, and to increase the therapeutic effectiveness and safety of cancer therapy, many substances have been looked into as drug carriers. Lipid-based nanoparticles (LBNPs) have significantly attracted interest recently. These natural biomolecules that alternate to other polymers are frequently recycled in medicine due to their amphipathic properties. Lipid nanoparticles typically provide a variety of benefits, including biocompatibility and biodegradability. This review covers different classes of LBNPs, including their characterization and different synthesis technologies. This review discusses the most significant advancements in lipid nanoparticle technology and their use in medicine administration. Moreover, the review also emphasized the applications of lipid nanoparticles that are used in different cancer treatment types.

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Section: Classification Of Lbnpsmentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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“…Various targeting approaches and their impact are also demonstrated. Other review articles discussed different nanoparticles in HCC [ 43 , 44 ] as well as nanoparticles targeting in HCC [ 45 , 46 ]. However, to the best of our knowledge, this is the first review article to focus on lipidic nanoparticles in delivering anti-neoplastic drugs for HCC.…”

Section: Introductionmentioning

confidence: 99%

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

et al. 2022

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Liver cancer is considered one of the deadliest diseases with one of the highest disease burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is considered to be the most common type. Multiple conventional approaches are being used in treating hepatocellular carcinoma. Focusing on drug treatment, regular agents in conventional forms fail to achieve the intended clinical outcomes. In order to improve the treatment outcomes, utilizing nanoparticles—specifically lipid based nanoparticles—are considered to be one of the most promising approaches being set in motion. Multiple forms of lipid based nanoparticles exist including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, phytosomes, lipid coated nanoparticles, and nanoassemblies. Multiple approaches are used to enhance the tumor uptake as well tumor specificity such as intratumoral injection, passive targeting, active targeting, and stimuli responsive nanoparticles. In this review, the effect of utilizing lipidic nanoparticles is being discussed as well as the different tumor uptake enhancement techniques used. Graphical Abstract

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