2014
DOI: 10.5858/arpa.2014-0299-cc
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Abstract: Context.—Primary cutaneous CD4+ small/medium T-cell lymphoma is a provisional and controversial entity with a broad differential diagnosis. Despite being an uncommon lymphoma, it is a frequent diagnostic consideration in cutaneous biopsies with a dense lymphoid infiltrate because it shows overlapping features with reactive lymphoid hyperplasia (pseudolymphoma) and a variety of other primary cutaneous and systemic lymphomas. However, proper classification of this process is important for determining patient pro… Show more

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Cited by 22 publications
(37 citation statements)
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References 54 publications
(183 reference statements)
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“…The head and/or neck are the most frequently affected sites (Figure ), but the trunk or extremities can also be involved. Multiple lesions, pain, itching or ulceration have occasionally been described . The main characteristics of all previously reported cases of PCSMP‐TLPD are summarized in Table A.…”
Section: Discussionmentioning
confidence: 99%
“…This drug‐induced variant should be carefully differentiated from drug‐induced nodular T‐cell pseudolymphoma. Predominance of either CD4+ or CD8+ T‐cells, marked eosinophilic infiltrate, absence of T‐cell marker loss and a mostly polyclonal TCR gene rearrangement are more suggestive of drug‐induced nodular T‐cell pseudolymphoma, but this is still debatable .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This indolent form of T-cell dyscrasia is characterized by the expression of germinal center markers among the T cells (T-helper phenotype). [185][186][187] This disorder typically shows a dense, nodular, or diffuse infiltrate in the dermis and sometimes the subcutis, with sparing of the epidermis. On some occasions, limited epidermotropism occurs.…”
Section: Cutaneous T-cell Lymphomasmentioning
confidence: 99%
“…While there is a tendency for EFGR mutations to occur more frequently in lepidic, papillary, and micropapillary carcinomas, the latter particularly in Asian populations, EGFR mutations may be encountered in any of the histologic subtypes. Similarly, ALK rearrangements have been most commonly associated with the solid subtype, particularly if there is an associated signet ring component, but gene rearrangements have been reported in all subtypes (25)(26)(27)(28)(29).…”
Section: Molecular Implicationsmentioning
confidence: 99%