Controversial aspects of the life cycle of Fasciola hepatica

Moazeni, Mohammad; Ahmadi, Amin

doi:10.1016/j.exppara.2016.07.010

Cited by 58 publications

(43 citation statements)

References 68 publications

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“…This might be explained by the fact that F. hepatica juvenile parasites follow a different route to reach the biliary tree that involves ingestion and digestion of host tissues while traversing the intestinal wall, migrating through the peritoneal cavity and penetrating the liver Glisson’s capsule (S1A Fig). Moreover, during their liver migration the parasites ingest parenchymal and other cells [20] and these compounds might be a result of the complex metabolic pathways and profiles of these ingested tissues.…”

Section: Resultsmentioning

confidence: 99%

“…Compounds of F. hepatica might be related to the different migratory route of the parasite to the biliary tree. Unlike Opisthorchis spp., newly excysted juveniles of F. hepatica exit the lumen of the small intestine, transverse the intestinal wall and migrate through the abdominal cavity to the Glisson’s capsule of the liver [20,24]. This parasite might deploy more complex biochemical processes and secretions, including the secretion of cathepsins [25–27] to accomplish this elaborate organ and tissue migration.…”

Section: Discussionmentioning

confidence: 99%

“…This parasite might deploy more complex biochemical processes and secretions, including the secretion of cathepsins [25–27] to accomplish this elaborate organ and tissue migration. The juvenile F. hepatica infects the liver by directly penetrating the Glisson’s capsule from the abdominal cavity, and thereafter burrows through the hepatic parenchyma to the bile ducts where it eventually matures into the egg-laying adult worm [20]. Components detected in the extracts of F. hepatica might be related with digestion of host tissues including blood such as hemoglobin, albumin and immunoglobin to support reproductive process including synthesis of eggs [20].…”

Section: Discussionmentioning

confidence: 99%

“…The juvenile F. hepatica infects the liver by directly penetrating the Glisson’s capsule from the abdominal cavity, and thereafter burrows through the hepatic parenchyma to the bile ducts where it eventually matures into the egg-laying adult worm [20]. Components detected in the extracts of F. hepatica might be related with digestion of host tissues including blood such as hemoglobin, albumin and immunoglobin to support reproductive process including synthesis of eggs [20]. This might not only explain the complex MS profile but also the compounds with elevated m/z as well as lower m/z that could be associated with free amino acids.…”

Section: Discussionmentioning

confidence: 99%

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Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Gouveia

Pakharukova

Sripa

et al. 2019

Preprint

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50 Chronic infections with the flatworm parasites Opisthorchis viverrini, Clonorchis sinensis and 51 Schistosoma haematobium are classified as group 1 biological carcinogens, i.e. definitive causes 52 of cancer. In addition, we reported findings that support the inclusion of Opisthorchis felineus in 53 this list of biological carcinogens. By contrast, infections with close phylogenetic relatives 54 including Fasciola hepatica have not been associated with carcinogenesis. Earlier reports revealed 55 of oxysterol metabolites of Opisthorchis liver fluke origin conjugated with DNA bases, suggesting 56 that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of 57 the infection with these food-borne pathogens. Here we employed liquid chromatography-mass 58 spectrometry (LC-MS/MS) to investigate, compare and contrast spectrograms of soluble extracts 59 from F. hepatica adult worms from bile ducts of cattle with those from O. viverrini and O. felineus 60 from experimentally-infected hamsters. F. hepatica displayed a complex spectrophotometric 61 profile. F. hepatica and Opisthorchis spp. shared several common compounds including oxysterol-62 like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of these Opisthorchis 63 species included far fewer compounds than F. hepatica. These findings support the postulate that 64 oxysterol-like metabolites of parasite origin can initiate carcinogenesis and they point to a 65 molecular basis for the inconsistencies among major groups of liver flukes concerning infection-66 induced malignancy. 67 (202 words) 68 69 70 71 72 73 4 74 Author Summary 75 Several species of trematodes are parasites of the human hepatobiliary tract. Infection with 76 two of these flukes, Clonorchis sinsensis and Opisthorchis viverrini, fresh water fish-borne 77 parasites that occur in East Asia is classified as group 1 carcinogens by the International Agency 78 for Research on Cancer (IARC), i.e. definitive causes of cancer in humans. By contrast, infection 79 with a different liver fluke, Fasciola hepatica, does not lead to malignant transformation of the 80 biliary tract. Given the close phylogeny of all three parasites, this difference in carcinogenicity is 81 intriguing and, if explained, likely of value in novel therapeutic approaches. The importance of the 82 current findings is informative because they present a mass spectrometric analysis and catalog of 83 the similarities and differences between fluke of the genus Opisthorchis and F. hepatica, 84 potentially identifying carcinogenic metabolites of liver fluke origin. These metabolites can be 85 expected to provide deeper understanding of helminth infection induced malignancy. 86 (149 words) 87 88 89 90 91 92 Keywords 93 Fasciola hepatica, Opisthorchis viverrini; Opisthorchis felineus; oxysterols; DNA adducts 94 95 5 96 97 More than 20% of cancer in the developing world are caused by infections [1]. The World 98 Health Organization's International Agency for Research on Cancer (IARC) recognizes ...

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Gouveia

Pakharukova

Sripa

et al. 2019

Preprint

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“…Adult flukes in the biliary tree cause obstructive symptoms such as biliary colic. 2 Most infections in the community remain undiagnosed. However, complications such as anemia and undernutrition may arise even in subjects with subclinical fascioliasis with devastating consequences for infected children.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru

Cabada

Morales

Webb

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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is the most widely distributed trematode-affecting humans. The Andes Mountains are highly endemic for fascioliasis. We report results of a cross-sectional study evaluating the epidemiology of Fasciola among children in 26 agricultural communities in the Cusco region of Peru. Children 3 to 16 years old were enrolled in preschools and schools. Blood from participants was tested for complete blood counts, transaminases, and Fasciola antibodies. Stool samples were tested for Fasciola and other parasites. A total of 2,515 children were included in the analysis and the mean age was 9.6 years (±3.6). Ten percent (253) of the children had at least one positive test for Fasciola, 6% had chronic infection, and 0.4% acute infection. The rest of the subjects had only antibodies against Fasciola. The prevalence of infection varied from 0% to 20% between communities. Children with evidence of Fasciola exposure were older, lived at higher altitudes, and had a lower socioeconomic status than children without infection. The logistic regression analysis showed that children from Ancahuasi district, older children, and children with higher measures of poverty were more likely to have Fasciola exposure. Fascioliasis is common in the Cusco region and associated with poverty. However, the distribution varies markedly between communities.

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Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species

et al. 2020

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Controversial aspects of the life cycle of Fasciola hepatica

Cited by 58 publications

References 68 publications

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru

Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species

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